PEPC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEPC_HUMAN
• UniProt AC: P20142
• Protein Name: Gastricsin
• Gene Name: PGC
• Organism: Homo sapiens (Human).
• Sequence Length: 388
• Subcellular Localization: Secreted.
• Protein Description: Hydrolyzes a variety of proteins..
• Protein Sequence: MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	EFLRTHKYDPAWKYR HHHHHCCCCCCCEEE	21.39	-
54	Phosphorylation	KYDPAWKYRFGDLSV CCCCCCEEEECCEEE	10.65	-
371	Phosphorylation	GDVFLRSYYSVYDLG EHHHHCCCCEEEECC	8.04	-
372	Phosphorylation	DVFLRSYYSVYDLGN HHHHCCCCEEEECCC	7.91	-
375	Phosphorylation	LRSYYSVYDLGNNRV HCCCCEEEECCCCEE	10.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEPC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEPC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEPC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNT1_HUMAN	CCNT1	physical	18200011
CDK9_HUMAN	CDK9	physical	18200011
ESR1_HUMAN	ESR1	physical	15784253

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.