MRC1_HUMAN - dbPTM
MRC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRC1_HUMAN
UniProt AC P22897
Protein Name Macrophage mannose receptor 1
Gene Name MRC1
Organism Homo sapiens (Human).
Sequence Length 1456
Subcellular Localization Endosome membrane
Single-pass type I membrane protein . Cell membrane
Single-pass type I membrane protein .
Protein Description Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein..
Protein Sequence MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGCVAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNWNTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMDPSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSDMKDLVGNIEQNEHSVI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationKRCVDAVSPSAVQTA
HHHHHCCCHHHHHHH		18.1722210691
42PhosphorylationCVDAVSPSAVQTAAC
HHHCCCHHHHHHHHC		33.3022210691
55PhosphorylationACNQDAESQKFRWVS
HCCCCHHHHCCCCCC		40.1522210691
62PhosphorylationSQKFRWVSESQIMSV
HHCCCCCCHHHHHHH		25.27-
64PhosphorylationKFRWVSESQIMSVAF
CCCCCCHHHHHHHHH		19.94-
104N-linked_GlycosylationFQKWECKNDTLLGIK
HHCEEECCCEECEEE		60.19UniProtKB CARBOHYD
200PhosphorylationWCGTTTDYDTDKLFG
EECCCCCCCCCHHCE		20.74-
344N-linked_GlycosylationGYICKKGNTTLNSFV
CEEECCCCCEECEEE		38.48UniProtKB CARBOHYD
389PhosphorylationKIQRDALTTCRKEGG
HHHHHHHHHHHHCCC		26.10-
390PhosphorylationIQRDALTTCRKEGGD
HHHHHHHHHHHCCCC		15.91-
529N-linked_GlycosylationLSTFAEANQTCNNEN
HHHHHHHHHHCCCCC		29.24UniProtKB CARBOHYD
633PhosphorylationKHWAEGVTHPPKPTT
HHHHCCCCCCCCCCC		39.25-
656PhosphorylationDWGASSRTSLCFKLY
CCCCCCCHHHHHHHH		28.1828555341
670AcetylationYAKGKHEKKTWFESR
HHCCCCCCCCHHHCH		56.0419807355
790O-linked_GlycosylationQTPKPEPTPAPQDNP
CCCCCCCCCCCCCCC		30.35OGP
820PhosphorylationYFSKEKETMDNARAF
EECCCHHHHHHHHHH		40.67-
850PhosphorylationEKKFLWKYVNRNDAQ
HHHHHHHHCCCCCHH		7.44-
860PhosphorylationRNDAQSAYFIGLLIS
CCCHHHHHHHHHHHC		10.85-
926N-linked_GlycosylationAFICQRHNSSINATT
CEEEECCCCCCCCEE		39.37UniProtKB CARBOHYD
928PhosphorylationICQRHNSSINATTVM
EEECCCCCCCCEEEE		25.7730576142
930N-linked_GlycosylationQRHNSSINATTVMPT
ECCCCCCCCEEEECC		32.93UniProtKB CARBOHYD
933PhosphorylationNSSINATTVMPTMPS
CCCCCCEEEECCCCC		16.6430576142
937O-linked_GlycosylationNATTVMPTMPSVPSG
CCEEEECCCCCCCCC		24.50OGP
1070PhosphorylationAGKWMDDTCDSKRGY
CCCCCCCCCCCCCCE		17.5930576142
1073PhosphorylationWMDDTCDSKRGYICQ
CCCCCCCCCCCEEEE		26.8030576142
1081PhosphorylationKRGYICQTRSDPSLT
CCCEEEECCCCCCCC		27.94-
1083PhosphorylationGYICQTRSDPSLTNP
CEEEECCCCCCCCCC		58.2124850871
1086PhosphorylationCQTRSDPSLTNPPAT
EECCCCCCCCCCCCE		53.4624850871
1093O-linked_GlycosylationSLTNPPATIQTDGFV
CCCCCCCEEECCCCE		21.28OGP
1093PhosphorylationSLTNPPATIQTDGFV
CCCCCCCEEECCCCE		21.2830206219
1096PhosphorylationNPPATIQTDGFVKYG
CCCCEEECCCCEEEC		33.9530206219
1102PhosphorylationQTDGFVKYGKSSYSL
ECCCCEEECCCCHHH		25.2030206219
1128PhosphorylationTYCKLHNSLIASILD
HHHHHCHHHHHHHHC		15.4822817900
1148PhosphorylationFAWLQMETSNERVWI
EEHHEECCCCCEEEE		31.3519690332
1149PhosphorylationAWLQMETSNERVWIA
EHHEECCCCCEEEEE		24.3219690332
1160N-linked_GlycosylationVWIALNSNLTDNQYT
EEEEEECCCCCCCCC		45.98UniProtKB CARBOHYD
1205N-linked_GlycosylationYWKTAHCNESFYFLC
CEEEEECCCCEEEEE		37.7718780401
1221O-linked_GlycosylationRSDEIPATEPPQLPG
CCCCCCCCCCCCCCC		43.61OGP
1268PhosphorylationLECLRMGSSLVSIES
HHHHHCCCCEEEHHH		15.9118510355
1279PhosphorylationSIESAAESSFLSYRV
EHHHHHHCCCCEEEE		22.9718510355
1280PhosphorylationIESAAESSFLSYRVE
HHHHHHCCCCEEEEE		23.0118510355
1311N-linked_GlycosylationEGTWLWINNSPVSFV
CCEEEEECCCCCEEE		31.20UniProtKB CARBOHYD
1454PhosphorylationNIEQNEHSVI-----
CHHCCCCCCC-----		18.4827499020
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MRC1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MRC1_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Identification of N-linked glycoproteins in human milk by hydrophilicinteraction liquid chromatography and mass spectrometry.";
Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.;
Proteomics 8:3833-3847(2008).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1205, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1128, AND MASSSPECTROMETRY.

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