3BHS2_HUMAN - dbPTM
3BHS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID 3BHS2_HUMAN
UniProt AC P26439
Protein Name 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Gene Name HSD3B2
Organism Homo sapiens (Human).
Sequence Length 372
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein. Mitochondrion membrane
Single-pass membrane protein.
Protein Description 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids..
Protein Sequence MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEGDILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDTLYTCALRPTYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLDSRWSLPLTLMYWIGFLLEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
95PhosphorylationFGVTHRESIMNVNVK
HCCCCCHHHCCCCCC		27.39-
150 (in isoform 2)Phosphorylation-13.3230631047
253PhosphorylationPSVRGQFYYISDDTP
CCCCCEEEEECCCCC		7.63-
259PhosphorylationFYYISDDTPHQSYDN
EEEECCCCCCCCCCC		27.88-
269PhosphorylationQSYDNLNYILSKEFG
CCCCCHHHHHHHHHC		13.3517081983
318PhosphorylationQPPFNRHTVTLSNSV
CCCCCCCEEEEECCE		16.3725262027
320PhosphorylationPFNRHTVTLSNSVFT
CCCCCEEEEECCEEE		26.1425262027
322PhosphorylationNRHTVTLSNSVFTFS
CCCEEEEECCEEEEE		20.0725262027
324PhosphorylationHTVTLSNSVFTFSYK
CEEEEECCEEEEEEC		18.4225262027
327PhosphorylationTLSNSVFTFSYKKAQ
EEECCEEEEEECHHC		14.9825262027
329PhosphorylationSNSVFTFSYKKAQRD
ECCEEEEEECHHCCH		32.7425262027
330PhosphorylationNSVFTFSYKKAQRDL
CCEEEEEECHHCCHH		16.5925262027
339PhosphorylationKAQRDLAYKPLYSWE
HHCCHHCCCCCCCHH		22.0426657352
344PhosphorylationLAYKPLYSWEEAKQK
HCCCCCCCHHHHHHH		35.3826657352
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of 3BHS2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of 3BHS2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of 3BHS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
3BHS1_HUMANHSD3B1physical
28514442
TM38A_HUMANTMEM38Aphysical
28514442
MTHR_HUMANMTHFRphysical
28514442
TOP2B_HUMANTOP2Bphysical
28514442
TOP2A_HUMANTOP2Aphysical
28514442
CATF_HUMANCTSFphysical
28514442
WBP11_HUMANWBP11physical
28514442
PYC_HUMANPCphysical
28514442
H2AY_HUMANH2AFYphysical
28514442
LETM1_HUMANLETM1physical
28514442
SYNC_HUMANNARSphysical
28514442
DDX46_HUMANDDX46physical
28514442
VRK1_HUMANVRK1physical
28514442
TCEA1_HUMANTCEA1physical
28514442
TBL3_HUMANTBL3physical
28514442
WDR36_HUMANWDR36physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of 3BHS2_HUMAN

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Related Literatures of Post-Translational Modification

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