| UniProt ID | TM38A_HUMAN | |
|---|---|---|
| UniProt AC | Q9H6F2 | |
| Protein Name | Trimeric intracellular cation channel type A | |
| Gene Name | TMEM38A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 299 | |
| Subcellular Localization |
Sarcoplasmic reticulum membrane Multi-pass membrane protein . Nucleus membrane . |
|
| Protein Description | Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.. | |
| Protein Sequence | MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDALEGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | SLGELALSFSRVPLF HHHHHHHHHCCCCCC | 18.64 | 24945436 | |
| 47 | Phosphorylation | EPGAVELSRRHPIAS CCCCCHHHCCCHHHH | 17.48 | - | |
| 177 | Phosphorylation | RGVWKPETNEILHMS CCCCCCCCCCEEECC | 46.83 | - | |
| 282 | Phosphorylation | HSAMPAKSKEELSEG CCCCCCCCHHHHCHH | 47.62 | 26437602 | |
| 287 | Phosphorylation | AKSKEELSEGSRKKK CCCHHHHCHHHHHHH | 43.10 | 26437602 | |
| 290 | Phosphorylation | KEELSEGSRKKKAKK HHHHCHHHHHHHHHC | 36.55 | 26437602 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TM38A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TM38A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TM38A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ARRB2_HUMAN | ARRB2 | physical | 26186194 | |
| NCEH1_HUMAN | NCEH1 | physical | 26186194 | |
| PCP2_HUMAN | PCP2 | physical | 26186194 | |
| DOK2_HUMAN | DOK2 | physical | 26186194 | |
| OXLD1_HUMAN | OXLD1 | physical | 28514442 | |
| NCEH1_HUMAN | NCEH1 | physical | 28514442 | |
| PCP2_HUMAN | PCP2 | physical | 28514442 | |
| DOK2_HUMAN | DOK2 | physical | 28514442 | |
| LZTL1_HUMAN | LZTFL1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
