LYVE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYVE1_HUMAN
• UniProt AC: Q9Y5Y7
• Protein Name: Lymphatic vessel endothelial hyaluronic acid receptor 1
• Gene Name: LYVE1
• Organism: Homo sapiens (Human).
• Sequence Length: 322
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internali
• Protein Description: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes..
• Protein Sequence: MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLVSKKANQQLNFTEAKEACRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISPNPKCGKNGVGVLIWKVPVSRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATQTTEFIVSDSTYSVASPYSTIPAPTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEPFVENKAAFKNEAAGFGGVPTALLVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKEMIETKVVKEEKANDSNPNEESKKTDKNPEESKSPSKTTVRCLEAEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	SCRIMGITLVSKKAN HHEEECEEEEEHHHH	18.51	-
53	N-linked_Glycosylation	KKANQQLNFTEAKEA HHHHCCCCHHHHHHH	37.14	16335952
55	Phosphorylation	ANQQLNFTEAKEACR HHCCCCHHHHHHHHH	33.68	28842319
67	Phosphorylation	ACRLLGLSLAGKDQV HHHHHCCHHCCHHHH	17.86	-
76	Phosphorylation	AGKDQVETALKASFE CCHHHHHHHHHHHEE	38.13	29083192
130	N-linked_Glycosylation	QFAAYCYNSSDTWTN HEHHHHCCCCCCCCC	31.32	UniProtKB CARBOHYD
146	Phosphorylation	CIPEIITTKDPIFNT CCCEECCCCCCCCCC	24.04	-
216	O-linked_Glycosylation	TSTMSTETEPFVENK CCCCCCCCCCCCCCH	49.39	OGP
280	Phosphorylation	QQKEMIETKVVKEEK HHHHHEEEHHHHHHH	20.43	22817900
297	Phosphorylation	DSNPNEESKKTDKNP CCCCCHHHHCCCCCH	33.02	17693683
298	Methylation	SNPNEESKKTDKNPE CCCCHHHHCCCCCHH	64.07	23644510
308	Ubiquitination	DKNPEESKSPSKTTV CCCHHHCCCCCHHHE	70.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYVE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYVE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYVE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53, AND MASS SPECTROMETRY.
PubMed: 19159218

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53, AND MASS SPECTROMETRY.
PubMed: 16335952

Phosphorylation

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297, AND MASSSPECTROMETRY.
PubMed: 17693683

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-280, AND MASSSPECTROMETRY.
PubMed: 19369195