COPA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPA1_HUMAN
• UniProt AC: Q9BXS0
• Protein Name: Collagen alpha-1(XXV) chain
• Gene Name: COL25A1 {ECO:0000312|HGNC:HGNC:18603}
• Organism: Homo sapiens (Human).
• Sequence Length: 654
• Subcellular Localization: Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.
• Protein Description: Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin..
• Protein Sequence: MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MLLKKHAGKGG ----CCCCCCCCCCC	38.25	7975685
5	Acetylation	---MLLKKHAGKGGG ---CCCCCCCCCCCC	38.36	7975695
30	Phosphorylation	AEQHCARTMPPCAVL HHHHHHHHCCHHHHH	18.59	-
113	Pyrrolidone_carboxylic_acid	AKIRIAREAPSECNC HHHHHHHHCCCCCCC	56.78	11927537
113	Pyrrolidone_carboxylic_acid	AKIRIAREAPSECNC HHHHHHHHCCCCCCC	56.78	11927537
212	Phosphorylation	PRGPPGDTGKDGPRG CCCCCCCCCCCCCCC	52.63	29396449
307	Phosphorylation	GEKGDPGSSAAGIKG CCCCCCCCCCCCCCC	23.38	23403867
308	Phosphorylation	EKGDPGSSAAGIKGE CCCCCCCCCCCCCCC	28.22	23403867
390	Phosphorylation	PKGKQGESGTRGPKG CCCCCCCCCCCCCCC	52.90	24905233
392	Phosphorylation	GKQGESGTRGPKGSK CCCCCCCCCCCCCCC	41.55	24905233
398	Phosphorylation	GTRGPKGSKGDRGEK CCCCCCCCCCCCCCC	39.32	24905233
468	Phosphorylation	GPKGEQGSPGIPGMD CCCCCCCCCCCCCCC	21.46	21815630
483	Phosphorylation	GEQGLKGSKGDMGDP CCCCCCCCCCCCCCC	31.70	30576142
493	Phosphorylation	DMGDPGMTGEKGGIG CCCCCCCCCCCCCCC	48.37	22210691
496	Acetylation	DPGMTGEKGGIGLPG CCCCCCCCCCCCCCC	64.88	30587789
511	Acetylation	LPGANGMKGEKGDSG CCCCCCCCCCCCCCC	66.37	30587795
514	Acetylation	ANGMKGEKGDSGMPG CCCCCCCCCCCCCCC	76.36	30587801
517	Phosphorylation	MKGEKGDSGMPGPQG CCCCCCCCCCCCCCC	45.73	23612710
585	Phosphorylation	EPGPRGPYGLPGKDG CCCCCCCCCCCCCCC	33.83	28787133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	11927537
COPA1_HUMAN	COL25A1	physical	15522881
A4_HUMAN	APP	physical	15522881

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.