dbPTM

CXA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CXA3_HUMAN
UniProt AC	Q9Y6H8
Protein Name	Gap junction alpha-3 protein
Gene Name	GJA3
Organism	Homo sapiens (Human).
Sequence Length	435
Subcellular Localization	Cell membrane Multi-pass membrane protein. Cell junction, gap junction.
Protein Description	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
Protein Sequence	MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKASRASSGRARPEDLAI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
119	Phosphorylation	EEQLKRESPSPKEPP HHHHHHCCCCCCCCC	34.41	-
121	Phosphorylation	QLKRESPSPKEPPQD HHHHCCCCCCCCCCC	58.86	15302935
123	Ubiquitination	KRESPSPKEPPQDNP HHCCCCCCCCCCCCC	83.58	22817900
378	Phosphorylation	APLLLDGSGSSLEGS CCEEECCCCCCCCCC	34.86	-
381	Phosphorylation	LLDGSGSSLEGSALA EECCCCCCCCCCCCC	33.68	-
390	Phosphorylation	EGSALAGTPEEEEQA CCCCCCCCCHHHHHH	23.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CXA3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CXA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CXA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CXA3_HUMAN !!

Drug and Disease Associations

Kegg Disease
H01202	Cataract
OMIM Disease
601885	Cataract 14, multiple types (CTRCT14)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CXA3_HUMAN

Related Literatures of Post-Translational Modification