| UniProt ID | CXA8_HUMAN | |
|---|---|---|
| UniProt AC | P48165 | |
| Protein Name | Gap junction alpha-8 protein | |
| Gene Name | GJA8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 433 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Cell junction, gap junction. |
|
| Protein Description | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.. | |
| Protein Sequence | MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGTNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLSKASSRARSDDLTV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 108 | Phosphorylation | RMEEKRKSREAEELG CHHHHHHHHHHHHHH | 39.11 | 29978859 | |
| 120 | Phosphorylation | ELGQQAGTNGGPDQG HHHHHCCCCCCCCCC | 33.43 | 29978859 | |
| 128 | Phosphorylation | NGGPDQGSVKKSSGS CCCCCCCCCCCCCCC | 25.73 | 29978859 | |
| 132 | Phosphorylation | DQGSVKKSSGSKGTK CCCCCCCCCCCCCCE | 33.93 | - | |
| 135 | Phosphorylation | SVKKSSGSKGTKKFR CCCCCCCCCCCEEEE | 29.84 | - | |
| 138 | Phosphorylation | KSSGSKGTKKFRLEG CCCCCCCCEEEEEEH | 34.49 | - | |
| 358 | Phosphorylation | EEAERLTTEEQEKVA HHHHHCCHHHHHHHC | 41.96 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CXA8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CXA8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CXA8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CXA8_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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