DRP2_HUMAN - dbPTM
DRP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DRP2_HUMAN
UniProt AC Q13474
Protein Name Dystrophin-related protein 2
Gene Name DRP2
Organism Homo sapiens (Human).
Sequence Length 957
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendrite . Perikaryon . Cell membrane
Peripheral membrane protein . Detected in Schwann cells at periaxonal myelin membranes.
Protein Description Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system..
Protein Sequence MQPMVMQGCPYTLPRCHDWQAADQFHHSSSLRSTCPHPQVRAAVTSPAPPQDGAGVPCLSLKLLNGSVGASGPLEPPAMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQINVRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPIKGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSKHYFSKHPQRGYLPVQSVLEADYSETPASSPMWPHADTHSRIEHFASRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSVATESKGELQKILAHLEDENRILQGELRRLKWQHEEAAEAPSLADGSTEAATDHRNEELLAEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQQSEGSHPREKGQTTPDTEAADDVGSKSQDVSLCLEDIMEKLRHAFPSVRSSDVTANTLLAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45PhosphorylationPQVRAAVTSPAPPQD
HHHEEEECCCCCCCC		25.0230206219
46PhosphorylationQVRAAVTSPAPPQDG
HHEEEECCCCCCCCC		16.6830206219
144PhosphorylationLVQQEKETHAAFMEE
EECCHHHHHHHHHHH		28.0729523821
216PhosphorylationSELWEKLTARCVDQH
HHHHHHHHHHHHHHH		24.1129083192
327PhosphorylationRWKQLQASVSERLKQ
HHHHHHHHHHHHHHH		17.14-
329PhosphorylationKQLQASVSERLKQLQ
HHHHHHHHHHHHHHH		17.95-
401PhosphorylationDLNNIKFSAYRTAMK
HHCCCCHHHHHHHHH		21.2724719451
414SumoylationMKLRRVQKALRLDLV
HHHHHHHHHHHCCHH		46.67-
414SumoylationMKLRRVQKALRLDLV
HHHHHHHHHHHCCHH		46.67-
422PhosphorylationALRLDLVTLTTALEI
HHHCCHHHHHHHHHH		26.1922468782
425PhosphorylationLDLVTLTTALEIFNE
CCHHHHHHHHHHHHH		32.1522468782
495PhosphorylationSGKMRALSFKTGIAC
CCCCEEEHHCCCEEH		24.5824719451
498PhosphorylationMRALSFKTGIACLCG
CEEEHHCCCEEHHHC		31.63-
588PhosphorylationWVNLEPQSMVWLAVL
HHCCCCHHHHHHHHH		26.47-
651PhosphorylationSKGNKLHYPIMEYYT
CCCCCCCCCEEEEEC		12.61-
657PhosphorylationHYPIMEYYTPTTSSE
CCCEEEEECCCCCCH		7.92-
682PhosphorylationNKFRSKHYFSKHPQR
HHHHCCCCCCCCCCC		17.18-
684PhosphorylationFRSKHYFSKHPQRGY
HHCCCCCCCCCCCCC		23.92-
691PhosphorylationSKHPQRGYLPVQSVL
CCCCCCCCCCHHHHE		15.26-
696PhosphorylationRGYLPVQSVLEADYS
CCCCCHHHHEEECCC		28.98-
748PhosphorylationDSLSPDDSIDEDQYL
CCCCCCCCCCHHHHH		39.04-
818PhosphorylationEEAAEAPSLADGSTE
HHHHHCCCCCCCCCC		43.15-
828PhosphorylationDGSTEAATDHRNEEL
CCCCCHHCCCCCHHH		39.11-
879PhosphorylationELLLQPPTESDGSGS
HHHCCCCCCCCCCCC		55.6024905233
881PhosphorylationLLQPPTESDGSGSAG
HCCCCCCCCCCCCCC		50.1524905233
884PhosphorylationPPTESDGSGSAGSSL
CCCCCCCCCCCCCCC		34.2724905233
886PhosphorylationTESDGSGSAGSSLAS
CCCCCCCCCCCCCCC		31.0224905233
889PhosphorylationDGSGSAGSSLASSPQ
CCCCCCCCCCCCCCC		23.1524905233
890PhosphorylationGSGSAGSSLASSPQQ
CCCCCCCCCCCCCCC		27.3424905233
893PhosphorylationSAGSSLASSPQQSEG
CCCCCCCCCCCCCCC		48.0924905233
894PhosphorylationAGSSLASSPQQSEGS
CCCCCCCCCCCCCCC		22.5624905233
898PhosphorylationLASSPQQSEGSHPRE
CCCCCCCCCCCCCCC		38.3824905233
901PhosphorylationSPQQSEGSHPREKGQ
CCCCCCCCCCCCCCC		26.6824905233
909PhosphorylationHPREKGQTTPDTEAA
CCCCCCCCCCCCHHH		49.3024076635
910PhosphorylationPREKGQTTPDTEAAD
CCCCCCCCCCCHHHC		15.9824076635
953PhosphorylationSSDVTANTLLAS---
CCCCCHHHHHCC---		22.2325332170
957PhosphorylationTANTLLAS-------
CHHHHHCC-------		40.5025332170
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DRP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DRP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DRP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRAX_HUMANPRXphysical
11430802
DAG1_HUMANDAG1physical
11430802
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DRP2_HUMAN

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Related Literatures of Post-Translational Modification

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