ALDOB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALDOB_HUMAN
• UniProt AC: P05062
• Protein Name: Fructose-bisphosphate aldolase B
• Gene Name: ALDOB
• Organism: Homo sapiens (Human).
• Sequence Length: 364
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite .
• Protein Sequence: MAHRFPALTQEQKKELSEIAQSIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFREILFSVDSSINQSIGGVILFHETLYQKDSQGKLFRNILKEKGIVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPSSLAIQENANALARYASICQQNGLVPIVEPEVIPDGDHDLEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMSEEDATLNLNAINLCPLPKPWKLSFSYGRALQASALAAWGGKAANKEATQEAFMKRAMANCQAAKGQYVHTGSSGAASTQSLFTACYTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAHRFPALT ------CCCCCCCCC	11.54	-
9	Phosphorylation	AHRFPALTQEQKKEL CCCCCCCCHHHHHHH	31.97	28857561
13	Acetylation	PALTQEQKKELSEIA CCCCHHHHHHHHHHH	47.68	24888359
13	Succinylation	PALTQEQKKELSEIA CCCCHHHHHHHHHHH	47.68	-
13	Succinylation	PALTQEQKKELSEIA CCCCHHHHHHHHHHH	47.68	-
22	Phosphorylation	ELSEIAQSIVANGKG HHHHHHHHHHHCCCC	15.26	28857561
36	Phosphorylation	GILAADESVGTMGNR CEEEECCCCCCCCHH	26.79	23911959
39	Phosphorylation	AADESVGTMGNRLQR EECCCCCCCCHHHHH	21.54	24972180
89	Phosphorylation	ETLYQKDSQGKLFRN EHHCCCCCCCHHHHH	48.11	24275569
101	Acetylation	FRNILKEKGIVVGIK HHHHHHHCCEEEEEE	52.96	27178108
119	Phosphorylation	GGAPLAGTNKETTIQ CCCCCCCCCCCCCCC	37.19	28857561
121	Succinylation	APLAGTNKETTIQGL CCCCCCCCCCCCCCC	57.16	-
121	Succinylation	APLAGTNKETTIQGL CCCCCCCCCCCCCCC	57.16	-
123	Phosphorylation	LAGTNKETTIQGLDG CCCCCCCCCCCCCCH	30.70	19664994
124	Phosphorylation	AGTNKETTIQGLDGL CCCCCCCCCCCCCHH	16.64	19664994
132	Phosphorylation	IQGLDGLSERCAQYK CCCCCHHHHHHHHHH	28.64	28985074
139	Acetylation	SERCAQYKKDGVDFG HHHHHHHHHCCCCHH	32.10	22361397
147	Acetylation	KDGVDFGKWRAVLRI HCCCCHHHHHHHHHH	33.24	20167786
160	Phosphorylation	RIADQCPSSLAIQEN HHHHHCCCCHHHHHC	45.68	25072903
161	Phosphorylation	IADQCPSSLAIQENA HHHHCCCCHHHHHCH	13.63	28258704
204	Phosphorylation	HDLEHCQYVTEKVLA CCHHHHHHHHHHHHH	18.09	25884760
206	Phosphorylation	LEHCQYVTEKVLAAV HHHHHHHHHHHHHHH	25.75	28152594
208	Acetylation	HCQYVTEKVLAAVYK HHHHHHHHHHHHHHH	32.93	30586865
208	Ubiquitination	HCQYVTEKVLAAVYK HHHHHHHHHHHHHHH	32.93	21890473
214	Phosphorylation	EKVLAAVYKALNDHH HHHHHHHHHHHCCCC	5.94	7998237
215	Methylation	KVLAAVYKALNDHHV HHHHHHHHHHCCCCE	39.54	-
223	Phosphorylation	ALNDHHVYLEGTLLK HHCCCCEEEECEEEC	8.48	28857561
227	Phosphorylation	HHVYLEGTLLKPNMV CCEEEECEEECCCCE	21.39	28857561
235	Phosphorylation	LLKPNMVTAGHACTK EECCCCEECCCCCCC	19.02	28857561
241	Phosphorylation	VTAGHACTKKYTPEQ EECCCCCCCCCCHHH	31.21	28857561
242	Acetylation	TAGHACTKKYTPEQV ECCCCCCCCCCHHHH	43.60	7744459
243	Acetylation	AGHACTKKYTPEQVA CCCCCCCCCCHHHHH	35.88	24888369
253	Phosphorylation	PEQVAMATVTALHRT HHHHHHHHHHHHHHH	12.81	28857561
269	S-nitrosocysteine	PAAVPGICFLSGGMS CCCCCEEEEECCCCC	3.30	-
269	S-nitrosylation	PAAVPGICFLSGGMS CCCCCEEEEECCCCC	3.30	15683743
272	Phosphorylation	VPGICFLSGGMSEED CCEEEEECCCCCHHH	17.04	24275569
276	Phosphorylation	CFLSGGMSEEDATLN EEECCCCCHHHCEEC	40.90	24275569
299	Phosphorylation	LPKPWKLSFSYGRAL CCCCEEEEECHHHHH	14.39	29449344
301	Phosphorylation	KPWKLSFSYGRALQA CCEEEEECHHHHHHH	24.25	24275569
302	Phosphorylation	PWKLSFSYGRALQAS CEEEEECHHHHHHHH	14.50	20561507
309	Phosphorylation	YGRALQASALAAWGG HHHHHHHHHHHHCCC	15.74	28857561
317	Succinylation	ALAAWGGKAANKEAT HHHHCCCHHCCHHHH	40.15	-
317	Succinylation	ALAAWGGKAANKEAT HHHHCCCHHCCHHHH	40.15	-
330	Acetylation	ATQEAFMKRAMANCQ HHHHHHHHHHHHHHH	30.47	7744471
349	Phosphorylation	QYVHTGSSGAASTQS CEEECCCCCCCCHHH	33.52	28857561
353	Phosphorylation	TGSSGAASTQSLFTA CCCCCCCCHHHHHHH	26.84	28857561
354	Phosphorylation	GSSGAASTQSLFTAC CCCCCCCHHHHHHHH	19.90	28857561
356	Phosphorylation	SGAASTQSLFTACYT CCCCCHHHHHHHHCC	26.07	28857561
362	Phosphorylation	QSLFTACYTY----- HHHHHHHCCC-----	13.45	27223
363	Phosphorylation	SLFTACYTY------ HHHHHHCCC------	23.73	46162179

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALDOB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALDOB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALDOB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MUC20_HUMAN	MUC20	physical	21988832
THIOM_HUMAN	TXN2	physical	21988832
ZEP1_HUMAN	HIVEP1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 229600: Hereditary fructose intolerance (HFI)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.