MUC20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MUC20_HUMAN
• UniProt AC: Q8N307
• Protein Name: Mucin-20
• Gene Name: MUC20
• Organism: Homo sapiens (Human).
• Sequence Length: 709
• Subcellular Localization: Secreted . Apical cell membrane . Basolateral cell membrane . Cell projection, microvillus membrane .
• Protein Description: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression..
• Protein Sequence: MGCLWGLALPLFFFCWEVGVSGSSAGPSTRRADTAMTTDDTEVPAMTLAPGHAALETQTLSAETSSRASTPAGPIPEAETRGAKRISPARETRSFTKTSPNFMVLIATSVETSAASGSPEGAGMTTVQTITGSDPREAIFDTLCTDDSSEEAKTLTMDILTLAHTSTEAKGLSSESSASSDSPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGLHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSWSPGSDVTLLAEALVTVTNIEVINCSITEIETTTSSIPGASDTDLIPTEGVKASSTSDPPALPDSTEAKPHITEVTASAETLSTAGTTESAAPDATVGTPLPTNSATEREVTAPGATTLSGALVTVSRNPLEETSALSVETPSYVKVSGAAPVSIEAGSAVGKTTSFAGSSASSYSPSEAALKNFTPSETPTMDIATKGPFPTSRDPLPSVPPTTTNSSRGTNSTLAKITTSAKTTMKPPTATPTTARTRPTTDVSAGENGGFLLLRLSVASPEDLTDPRVAERLMQQLHRELHAHAPHFQVSLLRVRRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	RADTAMTTDDTEVPA CCCCCCCCCCCCCCC	20.84	30576142
41	Phosphorylation	TAMTTDDTEVPAMTL CCCCCCCCCCCCEEE	41.51	30576142
65	Phosphorylation	QTLSAETSSRASTPA ECCCCCCCCCCCCCC	14.88	30576142
69	O-linked_Glycosylation	AETSSRASTPAGPIP CCCCCCCCCCCCCCC	33.54	55830039
70	O-linked_Glycosylation	ETSSRASTPAGPIPE CCCCCCCCCCCCCCH	19.04	55830043
80	O-linked_Glycosylation	GPIPEAETRGAKRIS CCCCHHHHCCCCCCC	41.26	55830045
92	Phosphorylation	RISPARETRSFTKTS CCCCCHHCCCCCCCC	26.51	-
94	Phosphorylation	SPARETRSFTKTSPN CCCHHCCCCCCCCCC	44.69	24719451
99	Phosphorylation	TRSFTKTSPNFMVLI CCCCCCCCCCEEEEE	21.28	23532336
148	Phosphorylation	DTLCTDDSSEEAKTL EEECCCCCCHHHHHH	42.32	29759185
149	Phosphorylation	TLCTDDSSEEAKTLT EECCCCCCHHHHHHH	46.58	29759185
161	Phosphorylation	TLTMDILTLAHTSTE HHHHHHHHHHCCCHH	23.41	23532336
166	Phosphorylation	ILTLAHTSTEAKGLS HHHHHCCCHHHCCCC	17.87	29759185
167	Phosphorylation	LTLAHTSTEAKGLSS HHHHCCCHHHCCCCC	40.91	29759185
173	Phosphorylation	STEAKGLSSESSASS CHHHCCCCCCCCCCC	40.50	29759185
423	N-linked_Glycosylation	VTNIEVINCSITEIE EECEEEEECEEEEEE	20.75	UniProtKB CARBOHYD
517	Phosphorylation	VTAPGATTLSGALVT EECCCCEEEECEEEE	20.56	-
519	Phosphorylation	APGATTLSGALVTVS CCCCEEEECEEEEEE	21.67	-
526	Phosphorylation	SGALVTVSRNPLEET ECEEEEEECCCCCCC	19.58	24719451
547	O-linked_Glycosylation	TPSYVKVSGAAPVSI CCCEEEECCCCCEEE	19.59	46515647
547	Phosphorylation	TPSYVKVSGAAPVSI CCCEEEECCCCCEEE	19.59	-
553	O-linked_Glycosylation	VSGAAPVSIEAGSAV ECCCCCEEEECCCCC	17.41	46515645
553	Phosphorylation	VSGAAPVSIEAGSAV ECCCCCEEEECCCCC	17.41	-
558	Phosphorylation	PVSIEAGSAVGKTTS CEEEECCCCCCEECC	27.16	-
558	O-linked_Glycosylation	PVSIEAGSAVGKTTS CEEEECCCCCCEECC	27.16	55832973
575	Phosphorylation	GSSASSYSPSEAALK CCCCCCCCCCHHHHC	24.73	28857561
585	Phosphorylation	EAALKNFTPSETPTM HHHHCCCCCCCCCCC	34.99	28857561
589	Phosphorylation	KNFTPSETPTMDIAT CCCCCCCCCCCCCCC	28.53	28857561
616	N-linked_Glycosylation	SVPPTTTNSSRGTNS CCCCCCCCCCCCCCC	35.58	UniProtKB CARBOHYD
618	Phosphorylation	PPTTTNSSRGTNSTL CCCCCCCCCCCCCCC	36.48	-
622	N-linked_Glycosylation	TNSSRGTNSTLAKIT CCCCCCCCCCCEEEE	35.50	UniProtKB CARBOHYD
623	Phosphorylation	NSSRGTNSTLAKITT CCCCCCCCCCEEEEC	25.33	-
624	Phosphorylation	SSRGTNSTLAKITTS CCCCCCCCCEEEECC	32.57	24425749
629	Phosphorylation	NSTLAKITTSAKTTM CCCCEEEECCCCCCC	17.62	24425749
631	Phosphorylation	TLAKITTSAKTTMKP CCEEEECCCCCCCCC	21.08	-
648	O-linked_Glycosylation	ATPTTARTRPTTDVS CCCCCCCCCCCCCCC	38.24	55826885
651	O-linked_Glycosylation	TTARTRPTTDVSAGE CCCCCCCCCCCCCCC	32.13	55826887
652	O-linked_Glycosylation	TARTRPTTDVSAGEN CCCCCCCCCCCCCCC	36.77	55826889
671	Phosphorylation	LLRLSVASPEDLTDP EEEEEECCHHHCCCH	27.02	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MUC20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MUC20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MUC20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB1_HUMAN	TUBB1	physical	28514442
ARF6_HUMAN	ARF6	physical	28514442
TRM44_HUMAN	TRMT44	physical	28514442
RBM15_HUMAN	RBM15	physical	28514442
GTPB2_HUMAN	GTPBP2	physical	28514442
AP3S1_HUMAN	AP3S1	physical	28514442
F118B_HUMAN	FAM118B	physical	28514442
RA51B_HUMAN	RAD51B	physical	28514442
MOG1_HUMAN	RANGRF	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
GLPK_HUMAN	GK	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
UCP5_HUMAN	SLC25A14	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
PPM1F_HUMAN	PPM1F	physical	28514442
FAKD3_HUMAN	FASTKD3	physical	28514442
PPT2_HUMAN	PPT2	physical	28514442
EFTU_HUMAN	TUFM	physical	28514442
GATB_HUMAN	GATB	physical	28514442
GT253_HUMAN	CERCAM	physical	28514442
RL23_HUMAN	RPL23	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.