dbPTM

RRP36_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRP36_HUMAN
UniProt AC	Q96EU6
Protein Name	Ribosomal RNA processing protein 36 homolog
Gene Name	RRP36
Organism	Homo sapiens (Human).
Sequence Length	259
Subcellular Localization	Nucleus, nucleolus . Concentrated in the fibrillar region of the nucleolus.
Protein Description	Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA..
Protein Sequence	MPGANYRAGAGAGAGARRPRGARDREEDGGGLEPAAVARDLLRGTSNMSFEELLELQSQVGTKTYKQLVAGNSPKKQASRPPIQNACVADKHRPLEMSAKIRVPFLRQVVPISKKVARDPRFDDLSGEYNPEVFDKTYQFLNDIRAKEKELVKKQLKKHLSGEEHEKLQQLLQRMEQQEMAQQERKQQQELHLALKQERRAQAQQGHRPYFLKKSEQRQLALAEKFKELKRSKKLENFLSRKRRRNAGKDRRHLPLSKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Methylation	-MPGANYRAGAGAGA -CCCCCCCCCCCCCC	26.76	115492937
45	Phosphorylation	ARDLLRGTSNMSFEE HHHHHHCCCCCCHHH	15.53	26074081
46	Phosphorylation	RDLLRGTSNMSFEEL HHHHHCCCCCCHHHH	33.10	26074081
49	Phosphorylation	LRGTSNMSFEELLEL HHCCCCCCHHHHHHH	33.48	26074081
58	Phosphorylation	EELLELQSQVGTKTY HHHHHHHHHHCCCHH	39.18	26074081
62	Phosphorylation	ELQSQVGTKTYKQLV HHHHHHCCCHHHHHH	22.74	26074081
64	Phosphorylation	QSQVGTKTYKQLVAG HHHHCCCHHHHHHCC	35.47	26074081
65	Phosphorylation	SQVGTKTYKQLVAGN HHHCCCHHHHHHCCC	9.78	26074081
73	Phosphorylation	KQLVAGNSPKKQASR HHHHCCCCCCCCCCC	36.86	29255136
79	Phosphorylation	NSPKKQASRPPIQNA CCCCCCCCCCCCCCC	42.71	26074081
98	Phosphorylation	KHRPLEMSAKIRVPF CCCCCCCCCEECCCC	19.62	22210691
100	Ubiquitination	RPLEMSAKIRVPFLR CCCCCCCEECCCCHH	24.60	29967540
114	Acetylation	RQVVPISKKVARDPR HHHHCCCHHHCCCCC	52.57	25953088
115	Ubiquitination	QVVPISKKVARDPRF HHHCCCHHHCCCCCC	34.04	-
129	Phosphorylation	FDDLSGEYNPEVFDK CCCCCCCCCHHHHHH	39.27	27642862
136	Ubiquitination	YNPEVFDKTYQFLND CCHHHHHHHHHHHHH	37.35	29967540
137	Phosphorylation	NPEVFDKTYQFLNDI CHHHHHHHHHHHHHH	25.13	26546556
138	Phosphorylation	PEVFDKTYQFLNDIR HHHHHHHHHHHHHHH	11.74	27642862
158	Acetylation	LVKKQLKKHLSGEEH HHHHHHHHHCCHHHH	59.37	7932663
161	Phosphorylation	KQLKKHLSGEEHEKL HHHHHHCCHHHHHHH	43.83	28985074
167	Ubiquitination	LSGEEHEKLQQLLQR CCHHHHHHHHHHHHH	54.20	29967540
167	Acetylation	LSGEEHEKLQQLLQR CCHHHHHHHHHHHHH	54.20	26051181
208	Ubiquitination	AQAQQGHRPYFLKKS HHHHCCCCCCCCCHH	34.14	29967540
213	Ubiquitination	GHRPYFLKKSEQRQL CCCCCCCCHHHHHHH	44.34	29967540
219 (in isoform 2)	Ubiquitination	-	30.68	21890473
220	Ubiquitination	KKSEQRQLALAEKFK CHHHHHHHHHHHHHH	4.61	21890473
222	Ubiquitination	SEQRQLALAEKFKEL HHHHHHHHHHHHHHH	9.58	22817900
225	Ubiquitination	RQLALAEKFKELKRS HHHHHHHHHHHHHHH	57.01	22817900
225	Acetylation	RQLALAEKFKELKRS HHHHHHHHHHHHHHH	57.01	25953088
225 (in isoform 1)	Ubiquitination	-	57.01	21890473
227	Ubiquitination	LALAEKFKELKRSKK HHHHHHHHHHHHHHH	73.53	22817900
229	Ubiquitination	LAEKFKELKRSKKLE HHHHHHHHHHHHHHH	6.02	29967540
230	Ubiquitination	AEKFKELKRSKKLEN HHHHHHHHHHHHHHH	56.57	22817900
234	Ubiquitination	KELKRSKKLENFLSR HHHHHHHHHHHHHHH	63.38	29967540
234	Acetylation	KELKRSKKLENFLSR HHHHHHHHHHHHHHH	63.38	26051181
240	Phosphorylation	KKLENFLSRKRRRNA HHHHHHHHHHHHHHC	31.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRP36_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRP36_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRP36_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RRP12_HUMAN	RRP12	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRP36_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.	17081983 [Abstract]