TEAD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEAD4_HUMAN
• UniProt AC: Q15561
• Protein Name: Transcriptional enhancer factor TEF-3
• Gene Name: TEAD4
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif..
• Protein Sequence: MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	NDAEGVWSPDIEQSF CCCCCCCCCCHHHHH	15.41	25627689
65	Ubiquitination	YPPCGRRKIILSDEG CCCCCCCEEEECCCC	32.51	29967540
69	Phosphorylation	GRRKIILSDEGKMYG CCCEEEECCCCCEEC	24.17	30266825
73	Ubiquitination	IILSDEGKMYGRNEL EEECCCCCEECHHHH	27.22	21890473
73	Ubiquitination	IILSDEGKMYGRNEL EEECCCCCEECHHHH	27.22	23000965
84	Phosphorylation	RNELIARYIKLRTGK HHHHHHHHHHHHCCC	8.06	21403953
91	Methylation	YIKLRTGKTRTRKQV HHHHHCCCCCCHHHH	33.93	-
96	Ubiquitination	TGKTRTRKQVSSHIQ CCCCCCHHHHHHHHH	55.21	-
123	Acetylation	KLKDQAAKDKALQSM HHHHHHHHHHHHHHH	63.88	30592899
134	Phosphorylation	LQSMAAMSSAQIISA HHHHHHHHHHHHHHH	20.14	25332170
135	Phosphorylation	QSMAAMSSAQIISAT HHHHHHHHHHHHHHH	15.88	24043423
140	Phosphorylation	MSSAQIISATAFHSS HHHHHHHHHHHHHHH	22.61	24043423
142	Phosphorylation	SAQIISATAFHSSMA HHHHHHHHHHHHHHH	24.06	25332170
146	Phosphorylation	ISATAFHSSMALARG HHHHHHHHHHHHHHC	18.50	24043423
147	Phosphorylation	SATAFHSSMALARGP HHHHHHHHHHHHHCC	10.25	24043423
153	Ubiquitination	SSMALARGPGRPAVS HHHHHHHCCCCCCCC	24.33	29967540
178	Sumoylation	AGTSHDVKPFSQQTY CCCCCCCCCCCCCEE	46.53	-
185	Phosphorylation	KPFSQQTYAVQPPLP CCCCCCEEECCCCCC	10.63	28102081
198	Phosphorylation	LPLPGFESPAGPAPS CCCCCCCCCCCCCCC	20.14	25159151
205	Phosphorylation	SPAGPAPSPSAPPAP CCCCCCCCCCCCCCC	33.33	26657352
207	Phosphorylation	AGPAPSPSAPPAPPW CCCCCCCCCCCCCCC	58.72	28102081
210	Ubiquitination	APSPSAPPAPPWQGR CCCCCCCCCCCCCCC	58.05	32142685
239	Ubiquitination	FLEQQQDPDTYNKHL HHHHCCCCCCCCCEE	31.35	29967540
253	Phosphorylation	LFVHIGQSSPSYSDP EEEEECCCCCCCCCC	38.72	25159151
254	Phosphorylation	FVHIGQSSPSYSDPY EEEECCCCCCCCCCH	15.24	20873877
256	Phosphorylation	HIGQSSPSYSDPYLE EECCCCCCCCCCHHH	38.94	20873877
257	Phosphorylation	IGQSSPSYSDPYLEA ECCCCCCCCCCHHHE	22.07	29523821
258	Phosphorylation	GQSSPSYSDPYLEAV CCCCCCCCCCHHHEE	36.13	20873877
261	Phosphorylation	SPSYSDPYLEAVDIR CCCCCCCHHHEEEHH	23.36	20873877
271	Phosphorylation	AVDIRQIYDKFPEKK EEEHHHHHHHCCHHC	12.54	-
273	Ubiquitination	DIRQIYDKFPEKKGG EHHHHHHHCCHHCCC	45.94	-
278	Acetylation	YDKFPEKKGGLKDLF HHHCCHHCCCHHHHH	57.45	18528523
282	Ubiquitination	PEKKGGLKDLFERGP CHHCCCHHHHHHHCC	56.51	29967540
282	Acetylation	PEKKGGLKDLFERGP CHHCCCHHHHHHHCC	56.51	18528531
296	Ubiquitination	PSNAFFLVKFWADLN CCCCEEEEEEEHHCC	3.98	32142685
315	Phosphorylation	DEGSSFYGVSSQYES CCCCCCCCCCCCCCC	15.72	10764782
322	Phosphorylation	GVSSQYESPENMIIT CCCCCCCCCCCEEEE	32.36	10764782
335	S-palmitoylation	ITCSTKVCSFGKQVV EEEECEEECCCHHHH	2.73	31043565
339	Ubiquitination	TKVCSFGKQVVEKVE CEEECCCHHHHHHHH	37.60	32142685
347	Phosphorylation	QVVEKVETEYARYEN HHHHHHHHHHHHHHC	36.96	28152594
349	Phosphorylation	VEKVETEYARYENGH HHHHHHHHHHHHCCC	12.09	28152594
352	Phosphorylation	VETEYARYENGHYSY HHHHHHHHHCCCEEE	12.94	-
357	Phosphorylation	ARYENGHYSYRIHRS HHHHCCCEEEEEECC	14.59	-
358	Phosphorylation	RYENGHYSYRIHRSP HHHCCCEEEEEECCH	11.40	24719451
367	S-palmitoylation	RIHRSPLCEYMINFI EEECCHHHHHHHHHH	3.90	31043565
420	Phosphorylation	YVFEVSASEHGAQHH EEEEECCCHHHHHHH	23.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEAD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEAD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEAD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWTR1_HUMAN	WWTR1	physical	16189514
CC85B_HUMAN	CCDC85B	physical	16189514
TRAF1_HUMAN	TRAF1	physical	25416956
PNMA1_HUMAN	PNMA1	physical	25416956
MOONR_HUMAN	KIAA0753	physical	25416956
CCDB1_HUMAN	CCNDBP1	physical	25416956
RABX5_HUMAN	RABGEF1	physical	25416956
CEP55_HUMAN	CEP55	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
CC172_HUMAN	CCDC172	physical	25416956
AMOL1_HUMAN	AMOTL1	physical	26186194
LYPA1_HUMAN	LYPLA1	physical	26186194
TEAD1_HUMAN	TEAD1	physical	26186194
TEAD2_HUMAN	TEAD2	physical	26186194
WWTR1_HUMAN	WWTR1	physical	26186194
FINC_HUMAN	FN1	physical	26186194
VASP_HUMAN	VASP	physical	26186194
PARN_HUMAN	PARN	physical	26186194
DLG3_HUMAN	DLG3	physical	26186194
YAP1_HUMAN	YAP1	physical	26186194
VTA1_HUMAN	VTA1	physical	26186194
SNX6_HUMAN	SNX6	physical	26186194
GNB1L_HUMAN	GNB1L	physical	26186194
MYOME_HUMAN	PDE4DIP	physical	21516116
SKI_HUMAN	SKI	physical	25670202
NCOR1_HUMAN	NCOR1	physical	25670202
TEAD2_HUMAN	TEAD2	physical	28514442
WWTR1_HUMAN	WWTR1	physical	28514442
TEAD1_HUMAN	TEAD1	physical	28514442
YAP1_HUMAN	YAP1	physical	28514442
DLG3_HUMAN	DLG3	physical	28514442
VASP_HUMAN	VASP	physical	28514442
PARN_HUMAN	PARN	physical	28514442
LYPA1_HUMAN	LYPLA1	physical	28514442
VTA1_HUMAN	VTA1	physical	28514442
FINC_HUMAN	FN1	physical	28514442
SNX6_HUMAN	SNX6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.