ISCA2_HUMAN - dbPTM
ISCA2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ISCA2_HUMAN
UniProt AC Q86U28
Protein Name Iron-sulfur cluster assembly 2 homolog, mitochondrial
Gene Name ISCA2
Organism Homo sapiens (Human).
Sequence Length 154
Subcellular Localization Mitochondrion .
Protein Description Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly..
Protein Sequence MAAAWGSSLTAATQRAVTPWPRGRLLTASLGPQARREASSSSPEAGEGQIRLTDSCVQRLLEITEGSEFLRLQVEGGGCSGFQYKFSLDTVINPDDRVFEQGGARVVVDSDSLAFVKGAQVDFSQELIRSSFQVLNNPQAQQGCSCGSSFSIKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MAAAWGSSLTAATQ
-CCCHHHCCHHHHHH		16.0925072903
8PhosphorylationMAAAWGSSLTAATQR
CCCHHHCCHHHHHHH		26.2925072903
10PhosphorylationAAWGSSLTAATQRAV
CHHHCCHHHHHHHCC		19.0525072903
13PhosphorylationGSSLTAATQRAVTPW
HCCHHHHHHHCCCCC		19.0025072903
22MethylationRAVTPWPRGRLLTAS
HCCCCCCCCCEEHHC		38.7154556901
27PhosphorylationWPRGRLLTASLGPQA
CCCCCEEHHCCCHHH		20.8430001349
29PhosphorylationRGRLLTASLGPQARR
CCCEEHHCCCHHHHH		28.7330001349
39PhosphorylationPQARREASSSSPEAG
HHHHHHHHCCCCCCC		26.4623312004
40PhosphorylationQARREASSSSPEAGE
HHHHHHHCCCCCCCC		41.7128450419
41PhosphorylationARREASSSSPEAGEG
HHHHHHCCCCCCCCC		47.6323401153
42PhosphorylationRREASSSSPEAGEGQ
HHHHHCCCCCCCCCC		28.8023911959
87PhosphorylationSGFQYKFSLDTVINP
CCCEEEEEECEEECC		22.6021406692
90PhosphorylationQYKFSLDTVINPDDR
EEEEEECEEECCCCC		28.6921406692
97MethylationTVINPDDRVFEQGGA
EEECCCCCCCCCCCE		42.26115480631
110PhosphorylationGARVVVDSDSLAFVK
CEEEEECCCCEEEEE		19.9330206219
112PhosphorylationRVVVDSDSLAFVKGA
EEEECCCCEEEEECC		26.0830206219
149PhosphorylationQGCSCGSSFSIKL--
CCCCCCCCCEEEC--		14.3224719451
151PhosphorylationCSCGSSFSIKL----
CCCCCCCEEEC----		22.2924719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ISCA2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ISCA2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ISCA2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ISCA2_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ISCA2_HUMAN

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Related Literatures of Post-Translational Modification

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