LGAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LGAT1_HUMAN
• UniProt AC: Q92604
• Protein Name: Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
• Gene Name: LPGAT1
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor..
• Protein Sequence: MAITLEEAPWLGWLLVKALMRFAFMVVNNLVAIPSYICYVIILQPLRVLDSKRFWYIEGIMYKWLLGMVASWGWYAGYTVMEWGEDIKAVSKDEAVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWLMDHIFKYTNFGIVSLVHGDFFIRQGRSYRDQQLLLLKKHLENNYRSRDRKWIVLFPEGGFLRKRRETSQAFAKKNNLPFLTNVTLPRSGATKIILNALVAQQKNGSPAGGDAKELDSKSKGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFPPSKGHKEAVSREMTLSNLWIFLIQSFAFLSGYMWYNIIQYFYHCLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	NLVAIPSYICYVIIL CHHHCCHHHHHHHCC	6.94	-
128	Ubiquitination	VAQMMWLMDHIFKYT HHHHHHHHHHHHHHH	1.76	21890473
164	Ubiquitination	DQQLLLLKKHLENNY HHHHHHHHHHHHCCC	37.81	21890473
164	Malonylation	DQQLLLLKKHLENNY HHHHHHHHHHHHCCC	37.81	26320211
164	Ubiquitination	DQQLLLLKKHLENNY HHHHHHHHHHHHCCC	37.81	21890473
165	Ubiquitination	QQLLLLKKHLENNYR HHHHHHHHHHHCCCC	54.08	27667366
197	Ubiquitination	KRRETSQAFAKKNNL HCHHHHHHHHHHCCC	13.21	21890473
200	Ubiquitination	ETSQAFAKKNNLPFL HHHHHHHHHCCCCCC	49.97	33845483
201	Ubiquitination	TSQAFAKKNNLPFLT HHHHHHHHCCCCCCE	47.87	27667366
233	Ubiquitination	VAQQKNGSPAGGDAK HHHHHCCCCCCCCHH	22.44	27667366
233	Phosphorylation	VAQQKNGSPAGGDAK HHHHHCCCCCCCCHH	22.44	30266825
234	Ubiquitination	AQQKNGSPAGGDAKE HHHHCCCCCCCCHHH	36.00	27667366
254	Ubiquitination	KGLQWIIDTTIAYPK CCCCEEEECEEECCC	28.76	22817900
290	Ubiquitination	HYRIFPIKDVPLETD EEEEEECCCCCCCCC	53.57	21906983
315	Phosphorylation	VEKEDLLSHFYETGA CCHHHHHHHHHHCCC	20.88	27251275
318	Phosphorylation	EDLLSHFYETGAFPP HHHHHHHHHCCCCCC	13.73	27251275
320	Phosphorylation	LLSHFYETGAFPPSK HHHHHHHCCCCCCCC	23.56	27251275
323	Ubiquitination	HFYETGAFPPSKGHK HHHHCCCCCCCCCCH	10.93	22817900
326	Phosphorylation	ETGAFPPSKGHKEAV HCCCCCCCCCCHHHH	52.05	27067055

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LGAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LGAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LGAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7C_HUMAN	HSPA8	physical	26186194
HS71L_HUMAN	HSPA1L	physical	26186194
POTEF_HUMAN	POTEF	physical	26186194
POTEF_HUMAN	POTEF	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.