HECD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HECD2_HUMAN
• UniProt AC: Q5U5R9
• Protein Name: Probable E3 ubiquitin-protein ligase HECTD2
• Gene Name: HECTD2
• Organism: Homo sapiens (Human).
• Sequence Length: 776
• Protein Description: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates..
• Protein Sequence: MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFSSFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPAKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEAVRVPS ------CCCCCCCCC	33.97	26074081
9	Phosphorylation	SEAVRVPSPATPLVV CCCCCCCCCCCCEEE	25.06	26074081
12	Phosphorylation	VRVPSPATPLVVAAP CCCCCCCCCEEEECC	22.12	26074081
53	Ubiquitination	AGLDRGAKGQISTFS CCCCCCCCCCHHHHH	54.92	21890473
53	Ubiquitination	AGLDRGAKGQISTFS CCCCCCCCCCHHHHH	54.92	21890473
53	Ubiquitination	AGLDRGAKGQISTFS CCCCCCCCCCHHHHH	54.92	21890473
57	Phosphorylation	RGAKGQISTFSSFIS CCCCCCHHHHHHHHH	18.60	29083192
58	Phosphorylation	GAKGQISTFSSFISA CCCCCHHHHHHHHHH	29.21	29083192
60	Phosphorylation	KGQISTFSSFISAVS CCCHHHHHHHHHHCC	25.16	29083192
61	Phosphorylation	GQISTFSSFISAVSP CCHHHHHHHHHHCCC	23.55	30622161
64	Phosphorylation	STFSSFISAVSPKKE HHHHHHHHHCCCCHH	22.17	29083192
67	Phosphorylation	SSFISAVSPKKEAAE HHHHHHCCCCHHHHH	30.62	30622161
77	Phosphorylation	KEAAENRSSPAHLVF HHHHHCCCCCCCEEC	52.86	25627689
78	Phosphorylation	EAAENRSSPAHLVFP HHHHCCCCCCCEECC	23.91	28555341
107	Phosphorylation	VRQKQRTSMDASSSE HHHHHHCCCCCCCCC	19.49	28348404
141	Acetylation	DFQEDVEKVKSSGDW HHHHHHHHHHHCCCH	55.61	20167786
171	Ubiquitination	ELNAAFKKDATASFN HHHHHHHCCCCCCCC	46.25	-
424	Phosphorylation	LNMKVRRTHLVSDSL EECEEHHHHHHCCCH	14.70	28348404
428	Phosphorylation	VRRTHLVSDSLDELT EHHHHHHCCCHHHHH	28.04	27251275
430	Phosphorylation	RTHLVSDSLDELTRK HHHHHCCCHHHHHHH	30.16	27251275
435	Phosphorylation	SDSLDELTRKRADLK CCCHHHHHHHHHHHH	31.90	27251275
461	Phosphorylation	GLDMGGLTKEWFLLL CCCCCCCCHHHHHHH	30.14	-
516	Phosphorylation	MGLAVYNSITLDIRF HHHHHHCCEECEECC	10.16	22210691
518	Phosphorylation	LAVYNSITLDIRFPP HHHHCCEECEECCCC	20.42	22210691
613	Dimethylation	ISVTNQNRKEYVQLY EEEECCCHHHHHHHH	24.34	-
613	Methylation	ISVTNQNRKEYVQLY EEEECCCHHHHHHHH	24.34	24379849

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HECD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HECD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HECD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIAS1_HUMAN	PIAS1	physical	26157031

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.