CCD40_HUMAN - dbPTM
CCD40_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCD40_HUMAN
UniProt AC Q4G0X9
Protein Name Coiled-coil domain-containing protein 40 {ECO:0000305}
Gene Name CCDC40 {ECO:0000312|HGNC:HGNC:26090}
Organism Homo sapiens (Human).
Sequence Length 1142
Subcellular Localization Cytoplasm . Cell projection, cilium . Localizes to cytoplasm and motile cilium.
Protein Description Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. [PubMed: 21131974 Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39]
Protein Sequence MAEPGGAAGRSHPEDGSASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQAEAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYTETSSPEGQISAADTTYPYFSPPQELPGEEAYDSVSGEAGLQGFQQEATGPPESRERRVTSPEPSHGVLGPSEQMGQVTSGPAVGRLTGSTEEPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPGPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationPGGAAGRSHPEDGSA
CCCCCCCCCCCCCCC		42.34-
17PhosphorylationRSHPEDGSASEGEKE
CCCCCCCCCCCCCCC		40.7330622161
19PhosphorylationHPEDGSASEGEKEGN
CCCCCCCCCCCCCCC		48.0830622161
29PhosphorylationEKEGNNESHMVSPPE
CCCCCCCCCCCCCCC		21.00-
151PhosphorylationEATGPPESRERRVTS
CCCCCCCHHCCCCCC		45.26-
157PhosphorylationESRERRVTSPEPSHG
CHHCCCCCCCCCCCC		36.4325693802
158PhosphorylationSRERRVTSPEPSHGV
HHCCCCCCCCCCCCC		25.1422210691
162PhosphorylationRVTSPEPSHGVLGPS
CCCCCCCCCCCCCCH		31.0722210691
169PhosphorylationSHGVLGPSEQMGQVT
CCCCCCCHHHCCCCC		38.3725693802
176PhosphorylationSEQMGQVTSGPAVGR
HHHCCCCCCCCCCCC		21.7822210691
177PhosphorylationEQMGQVTSGPAVGRL
HHCCCCCCCCCCCCC		43.8725693802
185PhosphorylationGPAVGRLTGSTEEPQ
CCCCCCCCCCCCCCC		27.9425693802
187PhosphorylationAVGRLTGSTEEPQGQ
CCCCCCCCCCCCCCC		27.6625693802
188PhosphorylationVGRLTGSTEEPQGQV
CCCCCCCCCCCCCCE		45.7925693802
252PhosphorylationQDQIQQPSTEEGAMA
HHHCCCCCCCCCHHH		44.08-
264PhosphorylationAMAERVESEGSDEEA
HHHHHHHCCCCCHHH		44.3827732954
267PhosphorylationERVESEGSDEEAEDE
HHHHCCCCCHHHCCC		37.4827732954
276PhosphorylationEEAEDEGSQLVVLDP
HHHCCCCCEEEEECC		20.4927732954
373PhosphorylationLQAARALYTKTCAAA
HHHHHHHHHHHHHHH		12.7626074081
374PhosphorylationQAARALYTKTCAAAN
HHHHHHHHHHHHHHH		22.2626074081
376PhosphorylationARALYTKTCAAANEE
HHHHHHHHHHHHHHH		10.2826074081
392PhosphorylationKKLAALQTEMENLAL
HHHHHHHHHHHHHHH		37.8426074081
427PhosphorylationQVVKKAETERIRAEI
HHHHHHHHHHHHHHH		35.1126437602
492UbiquitinationIDAISVEKRRIMQQW
CCCCCHHHHHHHHHH		44.8329967540
537PhosphorylationTDGEIEAYKKSIMKE
CCCHHHHHHHHHHCH		13.22-
635UbiquitinationTDAAIREKLQEHMTS
HHHHHHHHHHHHHCC		45.69-
665PhosphorylationKEKTNMMTHLSKING
HHHHCHHHHHHHCCC		14.6421955146
710PhosphorylationKKVNELITNSQSEIS
HHHHHHHHCCCCHHH		41.2529978859
712PhosphorylationVNELITNSQSEISRR
HHHHHHCCCCHHHHC		26.8329978859
714PhosphorylationELITNSQSEISRRTI
HHHHCCCCHHHHCHH		36.4029978859
717PhosphorylationTNSQSEISRRTILIE
HCCCCHHHHCHHHHH		16.2029978859
742PhosphorylationKQLERMVSELGGEEV
HHHHHHHHHHCCCCC		20.1224719451
797PhosphorylationEQEEQLASLDASKKE
HHHHHHHCCCCCHHH		35.0630377224
801PhosphorylationQLASLDASKKELHIM
HHHCCCCCHHHHHHH		43.8830377224
802UbiquitinationLASLDASKKELHIME
HHCCCCCHHHHHHHH		52.5729967540
864PhosphorylationLEQNNRVTENEFVRS
HHHCCCCCHHHHHHH		29.8330206219
871PhosphorylationTENEFVRSLKASERE
CHHHHHHHHHHHHHH		28.9930206219
875PhosphorylationFVRSLKASERETIKM
HHHHHHHHHHHHHHH		35.2830206219
952UbiquitinationVRLGQLLKQQEKMIR
HHHHHHHHHHHHHHH		59.5329967540
1027PhosphorylationEETQRNVSSSLLEKQ
HHHHHHHCHHHHHHH		20.12-
1028PhosphorylationETQRNVSSSLLEKQE
HHHHHHCHHHHHHHH		22.2623532336
1029PhosphorylationTQRNVSSSLLEKQEK
HHHHHCHHHHHHHHH		29.4824719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCD40_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCD40_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCD40_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
TRAF5_HUMANTRAF5physical
28514442
ANR26_HUMANANKRD26physical
28514442
UN13B_HUMANUNC13Bphysical
28514442
CENPH_HUMANCENPHphysical
28514442
HMMR_HUMANHMMRphysical
28514442
VPS53_HUMANVPS53physical
28514442
TNIP2_HUMANTNIP2physical
28514442
COG4_HUMANCOG4physical
28514442
FA83D_HUMANFAM83Dphysical
28514442
STIM1_HUMANSTIM1physical
28514442
TMTC4_HUMANTMTC4physical
28514442
PRS6A_HUMANPSMC3physical
28514442
K319L_HUMANKIAA0319Lphysical
28514442
CYH2_HUMANCYTH2physical
28514442
CYH1_HUMANCYTH1physical
28514442
PCM1_HUMANPCM1physical
28514442
POTEI_HUMANPOTEIphysical
28514442
PSMD9_HUMANPSMD9physical
28514442
T2H2L_HUMANGTF2H2Cphysical
27173435
PACRG_HUMANPACRGphysical
27173435
IF122_HUMANIFT122physical
27173435
IFT43_HUMANIFT43physical
27173435
TT21B_HUMANTTC21Bphysical
27173435
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCD40_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory