BBS12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BBS12_HUMAN
• UniProt AC: Q6ZW61
• Protein Name: Bardet-Biedl syndrome 12 protein
• Gene Name: BBS12
• Organism: Homo sapiens (Human).
• Sequence Length: 710
• Subcellular Localization: Cell projection, cilium . Located within the basal body of the primary cilium of differentiating preadipocytes.
• Protein Description: Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation..
• Protein Sequence: MVMACRVVNKRRHMGLQQLSSFAETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESLDLTSAVGQLLNEAVQAQNNTYRTGISTLLFLVGAWSSAVEECLHLGVPISIIVSVMSEGLNFCSEEVVSLHVPVHNIFDCMDSTKTFSQLETFSVSLCPFLQVPSDTDLIEELHGLKDVASQTLTISNLSGRPLKSYELFKPQTKVEADNNTSRTLKNSLLADTCCRQSILIHSRHFNRTDNTEGVSKPDGFQEHVTATHKTYRCNDLVELAVGLSHGDHSSMKLVEEAVQLQYQNACVQQGNCTKPFMFDISRIFTCCLPGLPETSSCVCPGYITVVSVSNNPVIKELQNQPVRIVLIEGDLTENYRHLGFNKSANIKTVLDSMRLQEDSSEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVMQAFAEAAGAVQVAYITQVNEDCVGDGVCVTFWRSSPLDVVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFWTCAYRLYYALKEEKVFLGGGAVEFLCLSCLHILAEQSLKKENHACSGWLHNTSSWLASSLAIYRPTVLKFLANGWQKYLSTLLYNTANYSSEFEASTYIQHHLQNATDSGSPSSYILNEYSKLNSRIFNSDISNKLEQIPRVYDVVTPKIEAWRRALDLVLLVLQTDSEIITGHGHTQINSQELTGFLFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	LLESLDLTSAVGQLL HHHHCCCHHHHHHHH	17.82	24719451
64	Phosphorylation	LESLDLTSAVGQLLN HHHCCCHHHHHHHHH	28.40	28348404
80	Phosphorylation	AVQAQNNTYRTGIST HHHHCCCCHHHCHHH	23.17	24719451
374	Ubiquitination	YRHLGFNKSANIKTV CHHCCCCCCCCHHHH	49.00	-
384	Phosphorylation	NIKTVLDSMRLQEDS CHHHHHHHHCCCCCC	11.14	24719451
494	Phosphorylation	RIAILLKTEGINLVT CEEEEEECCCCCEEE	39.14	25907765
501	Phosphorylation	TEGINLVTAVLTNPV CCCCCEEEEHHCCCC	17.76	25907765
505	Phosphorylation	NLVTAVLTNPVTAQM CEEEEHHCCCCCCCE	30.77	25907765
509	Phosphorylation	AVLTNPVTAQMQIKE EHHCCCCCCCEECCC	16.66	25907765
655	Ubiquitination	FNSDISNKLEQIPRV HCHHHHHHHHHCCCE	46.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BBS12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BBS12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BBS12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKKS_HUMAN	MKKS	physical	28514442
BBS7_HUMAN	BBS7	physical	28514442
PTPC1_HUMAN	PTPDC1	physical	27173435
2AAA_HUMAN	PPP2R1A	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.