MKKS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MKKS_HUMAN
• UniProt AC: Q9NPJ1
• Protein Name: McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin
• Gene Name: MKKS {ECO:0000312|HGNC:HGNC:7108}
• Organism: Homo sapiens (Human).
• Sequence Length: 570
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol . Nucleus . The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the prote
• Protein Description: Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis..
• Protein Sequence: MSRLEAKKPSLCKSEPLTTERVRTTLSVLKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTASIQNHVSSFSDCGLFTAILCCNLIENVQRLGLTPTTVIRLNKHLLSLCISYLKSETCGCRIPVDFSSTQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSLIVPLKGQRVIDSTVLPGILIEMSEVQLMRLLPIKKSTALKVALFCTTLSGDTSDTGEGTVVVSYGVSLENAVLDQLLNLGRQLISDHVDLVLCQKVIHPSLKQFLNMHRIIAIDRIGVTLMEPLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSKHFFHLIPNEATICSLLLCNRNDTAWDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDECTQTELQLIAEAFCSALESVVGSLEHDGGEILTDMKYGHLWSVQADSPCVANWPDLLSQCGCGLYNSQEELNWSFLRSTRRPFVPQSCLPHEAVGSASNLTLDCLTAKLSGLQVAVETANLILDLSYVIEDKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Ubiquitination	RTTLSVLKRIVTSCY HHHHHHHHHHHHHHH	37.61	-
125	Phosphorylation	RLNKHLLSLCISYLK HHCHHHHHHHHHHHH	27.79	-
129	Phosphorylation	HLLSLCISYLKSETC HHHHHHHHHHHHCCC	24.34	-
130	Phosphorylation	LLSLCISYLKSETCG HHHHHHHHHHHCCCC	9.76	-
156	Phosphorylation	ILLCLVRSILTSKPA HHHHHHHHHHHCCCC	17.92	-
199	Phosphorylation	GHIILGKSLIVPLKG CEEEECCEEEEEECC	22.87	23532336
300	Phosphorylation	CQKVIHPSLKQFLNM HHHHHCHHHHHHHCH	33.75	24114839
319	Phosphorylation	AIDRIGVTLMEPLTK EEECCCCEECCCHHH	18.38	-
354	Ubiquitination	VKDVCTAKFGSKHFF HHHHHCCEECCCEEE	31.91	-
431	Phosphorylation	KTHNDPESILKDDEC CCCCCHHHHCCCCCC	38.31	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MKKS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MKKS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN_HUMAN	PTN	physical	16169070
HSP74_HUMAN	HSPA4	physical	18094050
HSP7C_HUMAN	HSPA8	physical	18094050
HS90A_HUMAN	HSP90AA1	physical	18094050
CHIP_HUMAN	STUB1	physical	18094050
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.