PEPL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEPL_MOUSE
• UniProt AC: Q9R269
• Protein Name: Periplakin
• Gene Name: Ppl
• Organism: Mus musculus (Mouse).
• Sequence Length: 1755
• Subcellular Localization: Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.
• Protein Description: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling..
• Protein Sequence: MHSLFRKRNKGKYSPTVQTRSISNKELSDLIEQLQKNADQVERNIVDTEAKMQSDLARMQEGQLPEHRDAALQNVSDSEKLLYVLEADSAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQMYSLAVKEADPRVNWDTLVDEKLDKLSSQSFGTDLPLVDSQVEQHNIFHNEVKAIGPHLAKDKEQNSELQAKYQKLLTASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHTEGDQLLTAEHPGRNSIEAHMEAVHAEWKEYLNLLICEESHLKYMEDYHQFHKDMKDAQELLRKVDSDLNQKYSPDFKDRYQIELLLRELDDQEKALDKYEDVVRGLQRRGQQVVPLKYRRETPLKPIPVEALCDFESDQGLISRGYSYTLQKNNGESWELTDSTGKKLAAPAVCFIIPPTDPEALALADSLGSQYRSVRQKATGSKHALQQRHEVLRTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAIEDSAERAKGLKNITNELLQIEPEKTQCTAECEAFVQALPASGTAPLLKTRVEDTNQKYERLVWLLEAAQEKVDVANRLENSLQRGRELLASYENRLIQDDTMPESGHVLDRKRQELEAMASELQAHKSLLGEVGKNLQVAKQCSSSLASRFQEHCPDLERQEAEVHKLNQRFNNLSQQVERRAQSLQSARAAYDEYCSGYNRVLQFLAKTPSYEPQETDSLGQMETKLKNQKNLLDELASREQEVQKVYADSQQYQQAVKDYELEAEKLRSLLDLENGRNSHVNKRARLQSPAAKVKEEEAALAAKFTEVNAINRQRLQNLEFALNLLRQQPEAGVTHETLQGGKLSSGMEETWKIKKELEEEIERRQQLENEVKSAQEEIQTLKDQGPQESLVRKEVLKKVPDPALEESFQQLQQTLAEEQHKNQLLQEELGALQLRLQALEQETRDGGQEYVVKEVLRIEPDRAQEDEVLQLREELEALRRQKGAREAEVLLLQQRVAALAAEKSRVQEKVTEREVVKLQNDPQLEAEYRRLQEEHQREGTLREKQEEELSFLQAKLRRLEKERAMAEGKITVKEVLKVEKDAAVEREVNDLTRQYEDEAAKARSGQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKFRGAEEQLKSYQSELEALRNRGPQVEVKEVTKEVIKYTTDPETEQELQRLREEIMDKTRLIERCDLEIYQLKQEIQALKDTKPQVQTREVVQEILQFQEDPQTKKEVESLRIQLSEEQKKQVDLEGERASQEEKIKRKEEELAQQRKERVVRQEVVQYEDEPDLRAEVTAFTNSIDAELRQIDKLHVELRRLQHRRAELERQLEELERERQARRAAELEVQRLQQRLAALEQEEAKTGEKVTHTQKVVLQQDPQQTREHALLRAQLEEERHRRQLLEGELEPLRRKLAALEKAEIKEKVVFSESVQVEKGDTEQEIQRLKKSLEEESQSKRELDSEVTRLEAKLSELEFYNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEIEMAATETRDLKNITTIDSGTHLNSRLWSLEKELDDLKKMSKDKDLEIDELQRRLGSVAVKREQRENHLRRSIVVIDPDTGRELSPEEAHRAGLIDWKMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEDALQSGRLTAAQYDRYVNKDMSIQELAVLVSGQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RKRNKGKYSPTVQTR CCCCCCCCCCCCCCC	28.66	20139300
14	Phosphorylation	KRNKGKYSPTVQTRS CCCCCCCCCCCCCCC	19.99	20139300
16	Phosphorylation	NKGKYSPTVQTRSIS CCCCCCCCCCCCCCC	21.21	26643407
19	Phosphorylation	KYSPTVQTRSISNKE CCCCCCCCCCCCHHH	23.27	23375375
21	Phosphorylation	SPTVQTRSISNKELS CCCCCCCCCCHHHHH	33.48	23375375
23	Phosphorylation	TVQTRSISNKELSDL CCCCCCCCHHHHHHH	42.99	19854140
36	Ubiquitination	DLIEQLQKNADQVER HHHHHHHHCHHHHHH	63.80	22790023
76	Phosphorylation	DAALQNVSDSEKLLY HHHHHCCCCHHHHHH	42.86	28973931
78	Phosphorylation	ALQNVSDSEKLLYVL HHHCCCCHHHHHHHH	29.17	28973931
312	Phosphorylation	NLLICEESHLKYMED HHHHHCHHHHHHHHH	16.30	25293948
463	Phosphorylation	EALALADSLGSQYRS HHHHHHHHHHHHHHH	29.08	-
747	Phosphorylation	VLQFLAKTPSYEPQE HHHHHHCCCCCCCCC	16.32	20469934
749	Phosphorylation	QFLAKTPSYEPQETD HHHHCCCCCCCCCCC	47.57	20469934
750	Phosphorylation	FLAKTPSYEPQETDS HHHCCCCCCCCCCCC	32.60	20469934
755	Phosphorylation	PSYEPQETDSLGQME CCCCCCCCCCHHHHH	26.16	20469934
757	Phosphorylation	YEPQETDSLGQMETK CCCCCCCCHHHHHHH	41.65	20469934
763	Phosphorylation	DSLGQMETKLKNQKN CCHHHHHHHHHHHHH	36.01	20469934
777	Phosphorylation	NLLDELASREQEVQK HHHHHHHHHHHHHHH	49.31	25367039
884	Phosphorylation	TLQGGKLSSGMEETW CCCCCCCCCCHHHHH	28.47	28973931
885	Phosphorylation	LQGGKLSSGMEETWK CCCCCCCCCHHHHHH	53.23	-
895	Ubiquitination	EETWKIKKELEEEIE HHHHHHHHHHHHHHH	71.63	-
947	Phosphorylation	PDPALEESFQQLQQT CCHHHHHHHHHHHHH	20.98	-
1308	Phosphorylation	QTKKEVESLRIQLSE CCHHHHHHHHHHCCH	28.29	27742792
1314	Phosphorylation	ESLRIQLSEEQKKQV HHHHHHCCHHHHHHC	23.78	27742792
1329	Phosphorylation	DLEGERASQEEKIKR CCCCCHHCHHHHHHH	44.33	28973931
1348	Methylation	LAQQRKERVVRQEVV HHHHHHHHHHHHHHH	34.95	15230859
1373	Phosphorylation	EVTAFTNSIDAELRQ HHHHHHHCHHHHHHH	20.84	28973931
1583	Phosphorylation	LETRRLQSEIEMAAT HHHHHHHHHHHHHHH	45.17	-
1599	Phosphorylation	TRDLKNITTIDSGTH CCCCCCCEEECCCCC	27.39	29472430
1600	Phosphorylation	RDLKNITTIDSGTHL CCCCCCEEECCCCCH	20.99	29472430
1603	Phosphorylation	KNITTIDSGTHLNSR CCCEEECCCCCHHHH	41.56	30352176
1605	Phosphorylation	ITTIDSGTHLNSRLW CEEECCCCCHHHHHH	27.43	30352176
1609	Phosphorylation	DSGTHLNSRLWSLEK CCCCCHHHHHHHHHH	34.80	29472430
1656	Phosphorylation	RENHLRRSIVVIDPD HHHCCCCEEEEECCC	17.19	27742792
1719	Phosphorylation	RKSGKKFSIEDALQS CCCCCCEEHHHHHHH	33.67	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEPL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEPL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEPL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BFSP2_MOUSE	Bfsp2	physical	19029034
BFSP1_MOUSE	Bfsp1	physical	19029034
VIME_MOUSE	Vim	physical	19029034

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-1656, ANDMASS SPECTROMETRY.
PubMed: 19367708