BFSP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BFSP1_MOUSE
• UniProt AC: A2AMT1
• Protein Name: Filensin {ECO:0000303|PubMed:21745462, ECO:0000303|PubMed:9409766}
• Gene Name: Bfsp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 669
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Detected adjacent to the cell membrane.
• Protein Sequence: MYRRSYVFQARQERYERAQPAGPAAQPGGTAPGLAALQALGERVAVQVQRARALQQRHAGLRRQLDAFQRLGEQPGPEDALARHVEANLQRARDLTAEHARLERQEAEAQRALDEFRSKYENECECQLVLKEMLERLNKEADEALLRNLHLQLEAQFLQADISVAKDRYKKNLLEIQTYITVLQQIVQTAPQVSLVTGMRESGLLMQEKLFTEREVAALQNQLEEGREAVTHLQAQKAELQAQTTALEQAIKHAHECYDEELQLYNEQIENLRKEIEEAERSLERSSYDCRQLAVAQQTLRNELDRYHRIIEIEGSRLSSVFIETPISLITPSHGAPLSLGSSVKDLARAVQDITAAKPRQKALPKSLPKRKEIIAQDKVEETLEDAPLKPPQEPKALQVERKAEGGSQPGAGGGHGVSPTQEGGPEDVPDGGQISKAFGKLCKVVKERVSGHKEPEPEPPTDLFTKGRHVLVTGESSFVDPEFYSSSIPARGGVVISIEEDSMHHDGHVEPSPGQPMPPVENGQGVPQGREGDHSNHQQGTDKNGLRAKEPKDLEEKDDDGKKEAEGSRRPCPVIIPGPDEPSTSHSQTSGSNQGGPVGPASKSSSLLAKGPSKALSIKKVEVVESIEKISTESIQTYEETSVIVETLIGKSKGNKKLGEKSLPDTRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MYRRSYVFQARQ ---CCCCHHHHHHHH	19.36	-
35	Acetylation	GGTAPGLAALQALGE CCCHHHHHHHHHHHH	16.43	-
237	Ubiquitination	VTHLQAQKAELQAQT HHHHHHHHHHHHHHH	47.01	-
299	Phosphorylation	QLAVAQQTLRNELDR HHHHHHHHHHHHHHH	18.66	28059163
339	Phosphorylation	PSHGAPLSLGSSVKD CCCCCCCCCCCHHHH	29.62	-
432	Myristoylation	GPEDVPDGGQISKAF CCCCCCCCHHHHHHH	24.68	-
513	Phosphorylation	HDGHVEPSPGQPMPP CCCCCCCCCCCCCCC	28.32	-
569	Phosphorylation	GKKEAEGSRRPCPVI CCCCCCCCCCCCCEE	19.34	20139300
585	Phosphorylation	PGPDEPSTSHSQTSG CCCCCCCCCCCCCCC	40.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BFSP1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
34	L	Acetylation	[Filensin N-terminal fragment]: Acetylated at Ala-35 following proteolytic cleavage at Leu-34.	-
35	A	Acetylation	[Filensin N-terminal fragment]: Acetylated at Ala-35 following proteolytic cleavage at Leu-34.	-
431	D	Myristoylation	[Filensin C-terminal fragment]: Myristoylated at Gly-432 following proteolytic cleavage at Asp-431.	-
432	G	Myristoylation	[Filensin C-terminal fragment]: Myristoylated at Gly-432 following proteolytic cleavage at Asp-431.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BFSP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BFSP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.