SPY2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPY2_MOUSE
• UniProt AC: Q9QXV8
• Protein Name: Protein sprouty homolog 2
• Gene Name: Spry2
• Organism: Mus musculus (Mouse).
• Sequence Length: 315
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).
• Protein Description: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis..
• Protein Sequence: MEARAQSGNGSQPLLQTAHDSGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPSQVHSSRAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGPSFSHGPAAADGIIRVQPKSELKPGDVKPLSKDDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEARAQSGNGSQPL -CCCCCCCCCCCCCC	32.99	25338131
11	Phosphorylation	RAQSGNGSQPLLQTA CCCCCCCCCCCHHCH	32.40	25338131
17	Phosphorylation	GSQPLLQTAHDSGRQ CCCCCHHCHHHHCCC	26.40	-
21	Phosphorylation	LLQTAHDSGRQRGEP CHHCHHHHCCCCCCC	26.47	-
42	Phosphorylation	TQQVHVLSLDQIRAI HHHEEEEEHHHHHHH	28.89	29899451
55	Phosphorylation	AIRNTNEYTEGPTVV HHCCCCCCCCCCEEC	16.50	15004239
111	Phosphorylation	APLSRSISTVSSGSR CCCCCCEEEECCCCC	24.81	27841257
114	Phosphorylation	SRSISTVSSGSRSST CCCEEEECCCCCCCC	29.12	29514104
115	Phosphorylation	RSISTVSSGSRSSTR CCEEEECCCCCCCCC	36.13	25338131
117	Phosphorylation	ISTVSSGSRSSTRTS EEEECCCCCCCCCCC	30.82	29514104
119	Phosphorylation	TVSSGSRSSTRTSTS EECCCCCCCCCCCCC	37.45	25338131
120	Phosphorylation	VSSGSRSSTRTSTSS ECCCCCCCCCCCCCC	22.31	29899451
121	Phosphorylation	SSGSRSSTRTSTSSS CCCCCCCCCCCCCCC	38.93	-
121	O-linked_Glycosylation	SSGSRSSTRTSTSSS CCCCCCCCCCCCCCC	38.93	55414059
140	Phosphorylation	RLLGPSFSHGPAAAD HHCCCCCCCCCCCCC	31.69	29514104
164	Ubiquitination	ELKPGDVKPLSKDDL CCCCCCCCCCCHHCC	45.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
55	Y	Phosphorylation	Kinase	SRC	P05480	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPY2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPY2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TESK1_MOUSE	Tesk1	physical	17974561
SIAH2_MOUSE	Siah2	physical	16888801
SH3K1_MOUSE	Sh3kbp1	physical	15962011
SPY2_MOUSE	Spry2	physical	16339969
SPY4_MOUSE	Spry4	physical	16339969

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.