SPY4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPY4_MOUSE
• UniProt AC: Q9WTP2
• Protein Name: Protein sprouty homolog 4
• Gene Name: Spry4
• Organism: Mus musculus (Mouse).
• Sequence Length: 300
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
• Protein Description: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity)..
• Protein Sequence: MEPPVPQSSVPVNPSSVMVQPLLDSRAPHSRLQHPLTILPIDQMKTSHVENDYIDNPSLAPATGPKRPRGGPPELAPTPARCDQDITHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPVAEQASPRAVRLQPKVVHCKPLDLKGPTAPPELDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSGSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDTKTSRSDKPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPPVPQS -------CCCCCCCC	18.41	-
46	Phosphorylation	LPIDQMKTSHVENDY EEHHHHCCCCCCCCC	20.79	18846507
47	Phosphorylation	PIDQMKTSHVENDYI EHHHHCCCCCCCCCC	21.73	18846507
53	Phosphorylation	TSHVENDYIDNPSLA CCCCCCCCCCCCCCC	23.04	26032504
58	Phosphorylation	NDYIDNPSLAPATGP CCCCCCCCCCCCCCC	43.34	18846507
63	Phosphorylation	NPSLAPATGPKRPRG CCCCCCCCCCCCCCC	53.62	18846507
78	Phosphorylation	GPPELAPTPARCDQD CCCCCCCCCCCCCCC	24.79	28059163
126	Phosphorylation	PPVAEQASPRAVRLQ CCHHHHCCCCCEECC	18.02	25521595
277	Ubiquitination	RRPGCRCKHTNSVIC CCCCCCCCCCCCEEE	33.83	-
279	Phosphorylation	PGCRCKHTNSVICKA CCCCCCCCCCEEEEE	18.06	23984901
281	Phosphorylation	CRCKHTNSVICKAAS CCCCCCCCEEEEECC	17.64	30352176
285	Ubiquitination	HTNSVICKAASGDTK CCCCEEEEECCCCCC	35.54	-
293	Phosphorylation	AASGDTKTSRSDKPF ECCCCCCCCCCCCCC	31.31	-
294	Phosphorylation	ASGDTKTSRSDKPF- CCCCCCCCCCCCCC-	31.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPY4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPY4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPY4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIAH2_MOUSE	Siah2	physical	16888801
SPY4_MOUSE	Spry4	physical	16339969
SOS1_MOUSE	Sos1	physical	16339969

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.