TESK1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TESK1_MOUSE
• UniProt AC: O70146
• Protein Name: Dual specificity testis-specific protein kinase 1
• Gene Name: Tesk1
• Organism: Mus musculus (Mouse).
• Sequence Length: 627
• Protein Description: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)..
• Protein Sequence: MAGERPPLRGPGPGEAPGEGPGGAGGGPGRGRPSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSTRAPFTEITQHLEQILEQQPEATPLAKPPLTKAPLTYNQGSVPRGGPSATLPRPDPRLSRSRSDLFLPPSPESPPSWGDNLTRVNPFSLREDLRGGKIKLLDTPCKPATPLPLVPPSPLTSTQLPLVTTPDILVQPETPVRRCRSLPSSPELPRRMETALPGPGPSPMGPTEERMDCEGSSPEPEPPGLAPQLPLAVATDNFISTCSSASQPWSPRSGPPLNNNPPAVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREPEEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
186	Phosphorylation	RREDRGFTAVVGDFG EEHHCCCEEEECCCC	22.74	24719451
215	Phosphorylation	EPLAVVGSPYWMAPE CCEEEECCCCCCCHH	11.82	-
338	Methylation	YNQGSVPRGGPSATL CCCCCCCCCCCCCCC	61.62	24129315
342	Phosphorylation	SVPRGGPSATLPRPD CCCCCCCCCCCCCCC	36.84	20139300
353	Phosphorylation	PRPDPRLSRSRSDLF CCCCCCCCCCCCCCC	29.50	20139300
355	Phosphorylation	PDPRLSRSRSDLFLP CCCCCCCCCCCCCCC	32.53	23984901
357	Phosphorylation	PRLSRSRSDLFLPPS CCCCCCCCCCCCCCC	39.65	23984901
364	Phosphorylation	SDLFLPPSPESPPSW CCCCCCCCCCCCCCC	39.08	25293948
367	Phosphorylation	FLPPSPESPPSWGDN CCCCCCCCCCCCCCC	45.56	25293948
370	Phosphorylation	PSPESPPSWGDNLTR CCCCCCCCCCCCCCC	47.26	25293948
439	Phosphorylation	TPVRRCRSLPSSPEL CCCCCCCCCCCCCCC	48.54	25293948
442	Phosphorylation	RRCRSLPSSPELPRR CCCCCCCCCCCCCHH	64.91	29899451
443	Phosphorylation	RCRSLPSSPELPRRM CCCCCCCCCCCCHHH	22.06	25293948
541	Phosphorylation	PWNRAQHSLPRAAAL HHHHHHHCCCCHHHH	28.17	-
554	Phosphorylation	ALERTEPSPPPSAPR HHHCCCCCCCCCCCC	43.75	30635358
604	Phosphorylation	NLNCEAGSLLCHRGH CCCCCCCCEECCCCC	25.80	27149854
607	S-palmitoylation	CEAGSLLCHRGHHAK CCCCCEECCCCCCCC	2.20	28680068
617	Phosphorylation	GHHAKPPTPSLQLPG CCCCCCCCCCCCCCC	33.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TESK1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TESK1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TESK1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TESK1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.