HM20A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HM20A_MOUSE
• UniProt AC: Q9DC33
• Protein Name: High mobility group protein 20A
• Gene Name: Hmg20a
• Organism: Mus musculus (Mouse).
• Sequence Length: 346
• Subcellular Localization: Nucleus .
• Protein Description: Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4..
• Protein Sequence: MESLMASSTLPPLFADEDGSKESNDLATSGLTHPEGPYGSAATSTTNPEFVEDLSQGQLLQSEASNAVEGNEQRPEDEQRSKRGGWSKGRKRKKPLRDSNAPKSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDKERYMKELEQYQKTEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETEVKERSVFDIPIFTEEFLNHSKAREAELRQLRKSNMEFEERNAALQKHVESMRTAVEKLEVDVIQERSRNTVLQQHLETLRQMLTSSFASMPLPGSGEIPTVDTIDSYMNRLHSIILANPQDNENFIATVREVVNRLDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	LFADEDGSKESNDLA CCCCCCCCCCCCCCC	45.64	25338131
55	Phosphorylation	PEFVEDLSQGQLLQS HHHHHHHHHCHHHHH	44.58	25338131
92	Methylation	GWSKGRKRKKPLRDS CCCCCCCCCCCCCCC	51.36	30987643
97	Methylation	RKRKKPLRDSNAPKS CCCCCCCCCCCCCCC	54.56	30987649
99	Phosphorylation	RKKPLRDSNAPKSPL CCCCCCCCCCCCCCC	28.58	25619855
104	Phosphorylation	RDSNAPKSPLTGYVR CCCCCCCCCCHHHHH	24.88	26824392
107	Phosphorylation	NAPKSPLTGYVRFMN CCCCCCCHHHHHHHH	29.83	25619855
109	Phosphorylation	PKSPLTGYVRFMNER CCCCCHHHHHHHHHH	5.34	25619855
286	Phosphorylation	VLQQHLETLRQMLTS HHHHHHHHHHHHHHH	33.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HM20A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HM20A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HM20A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRAP_MOUSE	Brap	physical	23707952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.