SWP70_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SWP70_MOUSE
• UniProt AC: Q6A028
• Protein Name: Switch-associated protein 70
• Gene Name: Swap70
• Organism: Mus musculus (Mouse).
• Sequence Length: 585
• Subcellular Localization: Cytoplasm . Cell membrane . Nucleus . Cell projection, lamellipodium . Cytoplasm, cytoskeleton . Localizes predominantly to the nucleus in activated cells. Only a small amount can be detected in the cytoplasm.
• Protein Description: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)..
• Protein Sequence: MRGLKDELLKAIWHAFTALDLDRSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQDNFDKIEFNRMCWTLCVKKNLTKSPLLITEDDAFKVWVIFNFLSEDKYPLIIVPEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDNKDGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHKRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLIKCFDKTFEISASDKKKKQEWIQAIYSTIHLLKLGSPPPHKEARQRRKELRRKLLAEQEELERQMKELQAANENKQQELESVRKKLEEAASRAADEEKKRLQTQVELQTRFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEQQRVMKEQALQEAMAQLEQLELERKQALEQYEGVKKKLEMATHMTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTQAELEEREKSWKEKKTTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	Phosphorylation	VKKNLTKSPLLITED HHCCCCCCCEEEECC	18.62	26824392
145	Ubiquitination	EIEYLLKKLTEAMGG HHHHHHHHHHHHHCC	61.69	22790023
272	Acetylation	LPDKDGKKCLFLIKC CCCCCCCEEEEEEEE	41.52	22826441
302	Phosphorylation	QEWIQAIYSTIHLLK HHHHHHHHHHHHHHH	11.63	25367039
303	Phosphorylation	EWIQAIYSTIHLLKL HHHHHHHHHHHHHHC	18.12	25367039
304	Phosphorylation	WIQAIYSTIHLLKLG HHHHHHHHHHHHHCC	8.74	25367039
312	Phosphorylation	IHLLKLGSPPPHKEA HHHHHCCCCCCCHHH	44.67	22942356
388	Phosphorylation	VELQTRFSTELEREK HHHHHHCCHHHHHHH	20.06	27180971
389	Phosphorylation	ELQTRFSTELEREKL HHHHHCCHHHHHHHH	41.71	19854140
517	Phosphorylation	RKQALEQYEGVKKKL HHHHHHHHHHHHHHH	12.79	25159016
574	Methylation	TQAELEEREKSWKEK HHHHHHHHHHHHHHH	47.47	30989443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
517	Y	Phosphorylation	Kinase	SYK	P48025	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SWP70_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SWP70_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SWP70_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.