M3K19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K19_HUMAN
• UniProt AC: Q56UN5
• Protein Name: Mitogen-activated protein kinase kinase kinase 19
• Gene Name: MAP3K19
• Organism: Homo sapiens (Human).
• Sequence Length: 1328
• Protein Sequence: MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRVSLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSMPKPER ------CCCCCCHHH		25003641
3	Phosphorylation	-----MSSMPKPERH -----CCCCCCHHHH		26552605
83	Phosphorylation	RTEGVEITVTFPRDV CCCCEEEEEEECCCC		29759185
85	Phosphorylation	EGVEITVTFPRDVSP CCEEEEEEECCCCCC		29759185
97	Phosphorylation	VSPPQEMSQEDLKEK CCCCHHCCHHHHHHH		26437602
137	Phosphorylation	ELRKKKLTMRPLVLQ HHHHCCCCCCCEEEC		29759185
149	Phosphorylation	VLQKEESSRELCNVN EECCHHHHHHHHCCC		25247763
219	Phosphorylation	LSLLPTRSGVLTIPQ HHHCCCCCCCEECCC		-
223	Phosphorylation	PTRSGVLTIPQNHKF CCCCCCEECCCCCCC		-
242	Phosphorylation	ERNIPSLTSFVPKLS HCCCCHHHHHHCEEE		-
251	Phosphorylation	FVPKLSVSVRQSDEL HHCEEEEEEECCCCC		-
271	Phosphorylation	PPGALVKSLMDPTLR CCCHHHHHHHCCCCC		26699800
276	Phosphorylation	VKSLMDPTLRSSDGF HHHHHCCCCCCCCCC		25690035
356	Phosphorylation	IDCHGSKTRKPEEEN CCCCCCCCCCCHHHH		29449344
364	Phosphorylation	RKPEEENSQYLSSRK CCCHHHHHHHHHHHC		29449344
366	Phosphorylation	PEEENSQYLSSRKNE CHHHHHHHHHHHCCC		29449344
368	Phosphorylation	EENSQYLSSRKNESS HHHHHHHHHHCCCCH		29449344
369	Phosphorylation	ENSQYLSSRKNESSV HHHHHHHHHCCCCHH		29449344
392	Phosphorylation	EIVCTIPSKFQETQH CEEEECCCCCCCCCC		24719451
403	Phosphorylation	ETQHSEITPSQDEEM CCCCCCCCCCCCHHH		22210691
405	Phosphorylation	QHSEITPSQDEEMRN CCCCCCCCCCHHHHH		22210691
417	Phosphorylation	MRNNKAASKRVSLHK HHHCHHHHHHHHHCC		22817900
509	Ubiquitination	KPSLQTRKGTIHNNH CCCCCCCCCEEECCC		-
530	Ubiquitination	HQENDKHKMNSHRSK CCCCCCHHCHHHHHH		-
533	Phosphorylation	NDKHKMNSHRSKLDS CCCHHCHHHHHHCCC		29083192
536	Phosphorylation	HKMNSHRSKLDSKTK HHCHHHHHHCCCCCC		29083192
635	Phosphorylation	VPLSVQPTEPRLNYL EECCCCCCCCCCCCC		24114839
668	Phosphorylation	GIYEMFGTPVYCHVR CHHHHHCCCEEEEEE		-
742	2-Hydroxyisobutyrylation	EHKVLISKEKSSKAV HHEEEECCCCCCCHH		-
805	Phosphorylation	QNEFPPVSDLSIVEE CCCCCCCCCCCCEEE		22468782
1019	Phosphorylation	KEMGRETTKVKIQRH HHHCCCCCCEEEEEC		29759185
1027	Phosphorylation	KVKIQRHSSGLRIYD CEEEEECCCCCEEEE		23403867
1028	Phosphorylation	VKIQRHSSGLRIYDR EEEEECCCCCEEEEC		24719451
1033	Phosphorylation	HSSGLRIYDREEKFL CCCCCEEEECCCCEE		24719451
1049	Phosphorylation	SNEKKIFSENSLKSE ECCCCCCCCCCCCCC		30624053
1052	Phosphorylation	KKIFSENSLKSEEPI CCCCCCCCCCCCCCC		29449344
1072	Phosphorylation	EILGKGAYGTVYCGL EEECCCCCEEEEEEE		24905233
1074	Phosphorylation	LGKGAYGTVYCGLTS ECCCCCEEEEEEECC		24905233
1076	Phosphorylation	KGAYGTVYCGLTSQG CCCCEEEEEEECCCC		29759185
1080	Phosphorylation	GTVYCGLTSQGQLIA EEEEEEECCCCCEEE		29759185
1081	Phosphorylation	TVYCGLTSQGQLIAV EEEEEECCCCCEEEE		29759185
1095	Phosphorylation	VKQVALDTSNKLAAE EEEEEHHHCCHHHHH		-
1096	Phosphorylation	KQVALDTSNKLAAEK EEEEHHHCCHHHHHH		-
1219	Phosphorylation	AWAGLNGTHSDMLKS HHCCCCCCHHHHHHH		23403867
1221	Phosphorylation	AGLNGTHSDMLKSMH CCCCCCHHHHHHHCC		23403867
1226	Phosphorylation	THSDMLKSMHGTPYW CHHHHHHHCCCCCCC		23403867
1230	Phosphorylation	MLKSMHGTPYWMAPE HHHHCCCCCCCCCCH		23403867
1232	Phosphorylation	KSMHGTPYWMAPEVI HHCCCCCCCCCCHHH		23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M3K19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M3K19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K19_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of M3K19_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.