| UniProt ID | PA24B_HUMAN | |
|---|---|---|
| UniProt AC | P0C869 | |
| Protein Name | Cytosolic phospholipase A2 beta | |
| Gene Name | PLA2G4B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 781 | |
| Subcellular Localization |
Cytoplasm, cytosol . Isoform 3: Mitochondrion membrane Peripheral membrane protein. Early endosome membrane Peripheral membrane protein. Translocates to membrane vesicles in a calcium-dependent fashion. |
|
| Protein Description | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.. | |
| Protein Sequence | MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MAVAEVSRTCLLTV -CCHHHHHHHHHHHH | 17.24 | 30631047 | |
| 9 | Phosphorylation | AVAEVSRTCLLTVRV CHHHHHHHHHHHHHH | 10.45 | 24719451 | |
| 13 | Phosphorylation | VSRTCLLTVRVLQAH HHHHHHHHHHHHHHC | 8.04 | 24719451 | |
| 24 | Phosphorylation | LQAHRLPSKDLVTPS HHHCCCCCCCCCCHH | 43.31 | 24719451 | |
| 34 (in isoform 6) | Ubiquitination | - | 11.06 | - | |
| 37 | Phosphorylation | PSDCYVTLWLPTACS HHHCEEEEEECCCCC | 2.93 | 27251275 | |
| 130 | Phosphorylation | EVEFRLQSLADRGEW EEEEEEHHHHHCCCE | 30.07 | - | |
| 150 | Phosphorylation | VLVARELSCLHVQLE EEEEEEEEEEEEEEH | 15.18 | - | |
| 159 | Phosphorylation | LHVQLEETGDQKSSE EEEEEHHHCCCCCCC | 36.36 | - | |
| 164 | Phosphorylation | EETGDQKSSEHRVQL HHHCCCCCCCCEEEE | 35.01 | - | |
| 165 | Phosphorylation | ETGDQKSSEHRVQLV HHCCCCCCCCEEEEE | 44.45 | - | |
| 203 | Phosphorylation | ACWEQELSIRLQDAP CCHHEEEEEEECCCC | 12.62 | 24719451 | |
| 377 | Phosphorylation | KLGVLAPSQLQRYRQ CCCCCCHHHHHHHHH | 37.60 | - | |
| 382 | Phosphorylation | APSQLQRYRQELAER CHHHHHHHHHHHHHH | 12.04 | - | |
| 445 | Phosphorylation | ALNTKGQSLTTFEFG EEECCCCCCEEEECC | 36.03 | 22210691 | |
| 447 | Phosphorylation | NTKGQSLTTFEFGEW ECCCCCCEEEECCCC | 34.38 | 22210691 | |
| 448 | Phosphorylation | TKGQSLTTFEFGEWC CCCCCCEEEECCCCC | 26.85 | 22210691 | |
| 458 | Phosphorylation | FGEWCEFSPYEVGFP CCCCCCCCCCCCCCC | 12.32 | 22210691 | |
| 460 | Phosphorylation | EWCEFSPYEVGFPKY CCCCCCCCCCCCCCC | 23.27 | 22210691 | |
| 473 | Phosphorylation | KYGAFIPSELFGSEF CCCCCCCHHHHCCCC | 41.96 | - | |
| 708 | Phosphorylation | VSDSFREYSAPGVRR CCCHHHCCCCCCCCC | 13.08 | - | |
| 716 | Phosphorylation | SAPGVRRTPEEAAAG CCCCCCCCHHHHHCC | 25.20 | 30576142 | |
| 728 | Phosphorylation | AAGEVNLSSSDSPYH HCCCCCCCCCCCCCE | 23.69 | 30576142 | |
| 732 | Phosphorylation | VNLSSSDSPYHYTKV CCCCCCCCCCEEEEE | 29.34 | - | |
| 741 | Phosphorylation | YHYTKVTYSQEDVDK CEEEEEEECHHHHHH | 16.02 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PA24B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PA24B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PA24B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PA24B_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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