| UniProt ID | ABCG4_HUMAN | |
|---|---|---|
| UniProt AC | Q9H172 | |
| Protein Name | ATP-binding cassette sub-family G member 4 | |
| Gene Name | ABCG4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 646 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | May be involved in macrophage lipid homeostasis.. | |
| Protein Sequence | MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 (in isoform 2) | Phosphorylation | - | 2.18 | 22210691 | |
| 23 | Phosphorylation | GAVAMAVTLEDGAEP CCEEEEEECCCCCCC | 18.19 | 22210691 | |
| 34 | Phosphorylation | GAEPPVLTTHLKKVE CCCCCEEEHHHHHHH | 16.65 | 22210691 | |
| 35 | Phosphorylation | AEPPVLTTHLKKVEN CCCCEEEHHHHHHHH | 22.50 | 22210691 | |
| 82 | Ubiquitination | CWRKRGYKTLLKCLS CHHHHCHHHHHHHHC | 35.20 | - | |
| 422 | N-linked_Glycosylation | DDASKVFNNTGCLFF CCHHHHCCCHHHHHH | 48.41 | UniProtKB CARBOHYD | |
| 463 | Phosphorylation | EHLNYWYSLKAYYLA HHHHHHHHHHHHHHH | 14.84 | 24719451 | |
| 488 | Phosphorylation | VCPVVYCSIVYWMTG HCHHHEEEEEHHHHC | 9.45 | 28787133 | |
| 494 | Phosphorylation | CSIVYWMTGQPAETS EEEEHHHHCCCCHHH | 20.65 | 28787133 | |
| 501 | Phosphorylation | TGQPAETSRFLLFSA HCCCCHHHHHHHHHH | 16.73 | 28787133 | |
| 567 | Phosphorylation | TYLQWSSYLSYVRYG HHHHHHHHHHHHHHC | 8.31 | 11259231 | |
| 570 | Phosphorylation | QWSSYLSYVRYGFEG HHHHHHHHHHHCCCE | 6.07 | 11259243 | |
| 573 | Phosphorylation | SYLSYVRYGFEGVIL HHHHHHHHCCCEEEE | 19.00 | 11259255 | |
| 583 | Phosphorylation | EGVILTIYGMERGDL CEEEEEEEEECCCCE | 12.75 | 11259267 | |
| 604 | Phosphorylation | CPFREPQSILRALDV CCCCCCHHHHHHCCH | 34.01 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ABCG4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ABCG4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ABCG4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ABCG4_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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