LCA5L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LCA5L_HUMAN
• UniProt AC: O95447
• Protein Name: Lebercilin-like protein
• Gene Name: LCA5L
• Organism: Homo sapiens (Human).
• Sequence Length: 670
• Protein Sequence: MSLADLTKTNIDEHFFGVALENNRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHGLPASGGPANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSRIKVKDTTFRDKKSSLMEELFGSGYVLKTDQSSPGVAKGSEEPLQSKESHPLPPSQASTSHAFGDSKVTVVNSIKPSSPTEGKRKIII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	EKAINRNYLKQPVVK HHHHHCCCCCCCCCC	16.43	22817900
98	Phosphorylation	KEKEKKKYNVSKISQ CHHHHHHCCHHHHHC	29.67	22817900
104	Phosphorylation	KYNVSKISQSKGQKE HCCHHHHHCCCCCCE	31.94	22817900
145	Phosphorylation	AMAHRILSARLHKIK HHHHHHHHHHHHHHH	14.68	24719451
170	Phosphorylation	HKLEAILTENQFLKQ HHHHHHHCHHHHHHH	27.12	-
202	Acetylation	NLPQIMAKHQNEVKN CHHHHHHHHHHHHHH	28.48	24889733
220	Ubiquitination	LLRKSQEKERTLSRK HHHHHHHHHHHHHHH	44.88	-
303	Phosphorylation	LAIETRKTLAAQTAT HHHHHHHHHHHHHHH	20.52	-
337	Phosphorylation	ELEIKNIYSHRILKN HHHHHHHHHHHHHHH	14.07	24702127
338	Phosphorylation	LEIKNIYSHRILKNL HHHHHHHHHHHHHHC	11.51	22617229
380	O-linked_Glycosylation	RHQGTQKSDVPPLTT CCCCCCCCCCCCCCC	33.74	30379171
445	Phosphorylation	VQILLENTGRQKDKK HHHHHHHCCCCCCCC	25.11	-
505	Phosphorylation	QRNGVDDTLGKGTAP HHCCCCCCCCCCCCC	32.71	28796482
510	Phosphorylation	DDTLGKGTAPYTKGP CCCCCCCCCCCCCCC	28.13	28796482
513	Phosphorylation	LGKGTAPYTKGPLRQ CCCCCCCCCCCCCHH	20.72	28796482
514	Phosphorylation	GKGTAPYTKGPLRQR CCCCCCCCCCCCHHC	28.59	28796482
582	Phosphorylation	EPSFGKSSRIKVKDT CCCCCCCCCEEEECC	41.32	-
597	Phosphorylation	TFRDKKSSLMEELFG CCCHHHHHHHHHHHC	40.38	24719451
607	Phosphorylation	EELFGSGYVLKTDQS HHHHCCCEEEEECCC	12.33	24719451
614	Phosphorylation	YVLKTDQSSPGVAKG EEEEECCCCCCCCCC	41.11	24719451
659	Phosphorylation	VVNSIKPSSPTEGKR EEEECCCCCCCCCCC	43.90	27966365
660	Phosphorylation	VNSIKPSSPTEGKRK EEECCCCCCCCCCCC	44.35	29449344
662	Phosphorylation	SIKPSSPTEGKRKII ECCCCCCCCCCCCCC	60.36	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LCA5L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LCA5L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LCA5L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUV92_HUMAN	SUV39H2	physical	23455924
PCM1_HUMAN	PCM1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.