dbPTM

DLK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLK1_HUMAN
UniProt AC	P80370
Protein Name	Protein delta homolog 1
Gene Name	DLK1
Organism	Homo sapiens (Human).
Sequence Length	383
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	May have a role in neuroendocrine differentiation..
Protein Sequence	MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	O-linked_Glycosylation	RDVRACSSAPCANNR CCHHHHCCCCCCCCC	35.79	UniProtKB CARBOHYD
100	N-linked_Glycosylation	SSAPCANNRTCVSLD CCCCCCCCCEEEECC	23.32	7925474
143	O-linked_Glycosylation	SPCQHGGTCVDDEGR CCCCCCCEEECCCCC	17.59	UniProtKB CARBOHYD
163	O-linked_Glycosylation	CLCPPGFSGNFCEIV EECCCCCCCCCEEEE	38.45	UniProtKB CARBOHYD
165	N-linked_Glycosylation	CPPGFSGNFCEIVAN CCCCCCCCCEEEEEE	36.88	7925474
172	N-linked_Glycosylation	NFCEIVANSCTPNPC CCEEEEEECCCCCCC	27.07	7925474
214	O-linked_Glycosylation	RPVTNCASSPCQNGG CCCCCCCCCCCCCCC	36.69	UniProtKB CARBOHYD
222	O-linked_Glycosylation	SPCQNGGTCLQHTQV CCCCCCCCCEEEEEE	16.08	UniProtKB CARBOHYD
251	O-linked_Glycosylation	CVKKRALSPQQVTRL EEECCCCCHHHCCCC	21.48	UniProtKB CARBOHYD
256	O-linked_Glycosylation	ALSPQQVTRLPSGYG CCCHHHCCCCCCCCC	23.35	22171320
260	O-linked_Glycosylation	QQVTRLPSGYGLAYR HHCCCCCCCCCEEEE	49.60	UniProtKB CARBOHYD
269	O-linked_Glycosylation	YGLAYRLTPGVHELP CCEEEEECCCCCCCC	14.70	55830429
303 (in isoform 2)	Ubiquitination	-	22.71	-
353	Phosphorylation	KKNLLLQYNSGEDLA HCCEEEEECCCCCEE	15.97	-
355	Phosphorylation	NLLLQYNSGEDLAVN CEEEEECCCCCEEEE	38.33	29116813
375	Phosphorylation	KIDMTTFSKEAGDEE CCCCCEECCCCCCCC	27.74	26091039
376	Ubiquitination	IDMTTFSKEAGDEEI CCCCEECCCCCCCCC	47.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DLK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAS1_HUMAN	GAS1	physical	11846389
GRN_HUMAN	GRN	physical	11846389
TBB8_HUMAN	TUBB8	physical	26186194
DCAKD_HUMAN	DCAKD	physical	26186194
AVR2B_HUMAN	ACVR2B	physical	26186194
ZN696_HUMAN	ZNF696	physical	26186194
SMG8_HUMAN	SMG8	physical	26186194
AT1A3_HUMAN	ATP1A3	physical	26186194
AT12A_HUMAN	ATP12A	physical	26186194
NCLN_HUMAN	NCLN	physical	26186194
TBC15_HUMAN	TBC1D15	physical	26186194
AT131_HUMAN	ATP13A1	physical	26186194
TFR1_HUMAN	TFRC	physical	26186194
NU188_HUMAN	NUP188	physical	26186194
PTH2_HUMAN	PTRH2	physical	26186194
WDR44_HUMAN	WDR44	physical	26186194
P121A_HUMAN	POM121	physical	26186194
SCAM1_HUMAN	SCAMP1	physical	26186194
NFRKB_HUMAN	NFRKB	physical	26186194
F234B_HUMAN	KIAA1467	physical	26186194
CEP78_HUMAN	CEP78	physical	26186194
LEMD2_HUMAN	LEMD2	physical	26186194
ZZEF1_HUMAN	ZZEF1	physical	26186194
AT2B4_HUMAN	ATP2B4	physical	26186194
M18BP_HUMAN	MIS18BP1	physical	26186194
C2CD5_HUMAN	C2CD5	physical	26186194
PDS5A_HUMAN	PDS5A	physical	26186194
LAP4B_HUMAN	LAPTM4B	physical	26186194
TM214_HUMAN	TMEM214	physical	26186194
SCAM2_HUMAN	SCAMP2	physical	26186194
K1161_HUMAN	KIAA1161	physical	26186194
PGES2_HUMAN	PTGES2	physical	26186194
CABL2_HUMAN	CABLES2	physical	26186194
STEA3_HUMAN	STEAP3	physical	26186194
CNDH2_HUMAN	NCAPH2	physical	26186194
AN13C_HUMAN	ANKRD13C	physical	26186194
FND3A_HUMAN	FNDC3A	physical	26186194
TCAF2_HUMAN	FAM115C	physical	26186194
CABL1_HUMAN	CABLES1	physical	26186194
FGFR1_HUMAN	FGFR1	physical	26186194
PCYOX_HUMAN	PCYOX1	physical	26186194
PRAF2_HUMAN	PRAF2	physical	26186194
INT7_HUMAN	INTS7	physical	26186194
DYH14_HUMAN	DNAH14	physical	26186194
NLRX1_HUMAN	NLRX1	physical	26186194
GOGA2_HUMAN	GOLGA2	physical	26186194
UBE3B_HUMAN	UBE3B	physical	26186194
ANR27_HUMAN	ANKRD27	physical	26186194
MOT8_HUMAN	SLC16A2	physical	26186194
PSN2_HUMAN	PSEN2	physical	26186194
DIP2A_HUMAN	DIP2A	physical	26186194
MP2K7_HUMAN	MAP2K7	physical	26186194
MBLC2_HUMAN	MBLAC2	physical	26186194
OCLN_HUMAN	OCLN	physical	26186194
ANO6_HUMAN	ANO6	physical	26186194
S19A2_HUMAN	SLC19A2	physical	26186194
EGFL7_HUMAN	EGFL7	physical	26186194
ADPGK_HUMAN	ADPGK	physical	26186194
CSPG5_HUMAN	CSPG5	physical	26186194
FIBP_HUMAN	FIBP	physical	26186194
TMM94_HUMAN	KIAA0195	physical	26186194
SGPP1_HUMAN	SGPP1	physical	26186194
DEN6A_HUMAN	DENND6A	physical	26186194
OSTC_HUMAN	OSTC	physical	26186194
BRI3B_HUMAN	BRI3BP	physical	26186194
AVR2B_HUMAN	ACVR2B	physical	28514442
AN13C_HUMAN	ANKRD13C	physical	28514442
UBE3B_HUMAN	UBE3B	physical	28514442
TMM94_HUMAN	KIAA0195	physical	28514442
CABL2_HUMAN	CABLES2	physical	28514442
CABL1_HUMAN	CABLES1	physical	28514442
C2CD5_HUMAN	C2CD5	physical	28514442
LAP4B_HUMAN	LAPTM4B	physical	28514442
SCAM1_HUMAN	SCAMP1	physical	28514442
K1161_HUMAN	KIAA1161	physical	28514442
FIBP_HUMAN	FIBP	physical	28514442
CSPG5_HUMAN	CSPG5	physical	28514442
TCAF2_HUMAN	FAM115C	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
OSTC_HUMAN	OSTC	physical	28514442
ANR27_HUMAN	ANKRD27	physical	28514442
NFRKB_HUMAN	NFRKB	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
ZN627_HUMAN	ZNF627	physical	28514442
ANO6_HUMAN	ANO6	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
PGES2_HUMAN	PTGES2	physical	28514442
BRI3B_HUMAN	BRI3BP	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
DCAKD_HUMAN	DCAKD	physical	28514442
MP2K7_HUMAN	MAP2K7	physical	28514442
PRAF2_HUMAN	PRAF2	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
ORC4_HUMAN	ORC4	physical	28514442
LEMD2_HUMAN	LEMD2	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
SGPP1_HUMAN	SGPP1	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442
AT131_HUMAN	ATP13A1	physical	28514442
PCYOX_HUMAN	PCYOX1	physical	28514442
S38A2_HUMAN	SLC38A2	physical	28514442
STEA3_HUMAN	STEAP3	physical	28514442
EGFL7_HUMAN	EGFL7	physical	28514442
NCLN_HUMAN	NCLN	physical	28514442
DYH14_HUMAN	DNAH14	physical	28514442
EVA1B_HUMAN	EVA1B	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLK1_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Protein structure of fetal antigen 1 (FA1). A novel circulating humanepidermal-growth-factor-like protein expressed in neuroendocrinetumors and its relation to the gene products of dlk and pG2."; Jensen C.H., Krogh T.N., Hoejrup P., Clausen P.P., Skjoedt K.,Larsson L.-I., Enghild J.J., Teisner B.; Eur. J. Biochem. 225:83-92(1994). Cited for: PROTEIN SEQUENCE OF 24-383, GLYCOSYLATION AT SER-94; ASN-100; THR-143;SER-163; ASN-165; ASN-172; SER-214; THR-222; SER-251 AND SER-260, ANDVARIANT GLY-101.	7925474 [Abstract]
O-linked Glycosylation
Reference	PubMed
"Human urinary glycoproteomics; attachment site specific analysis ofN-and O-linked glycosylations by CID and ECD."; Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.; Mol. Cell. Proteomics 0:0-0(2011). Cited for: GLYCOSYLATION AT THR-256, STRUCTURE OF CARBOHYDRATES, AND MASSSPECTROMETRY.	22171320 [Abstract]
"Protein structure of fetal antigen 1 (FA1). A novel circulating humanepidermal-growth-factor-like protein expressed in neuroendocrinetumors and its relation to the gene products of dlk and pG2."; Jensen C.H., Krogh T.N., Hoejrup P., Clausen P.P., Skjoedt K.,Larsson L.-I., Enghild J.J., Teisner B.; Eur. J. Biochem. 225:83-92(1994). Cited for: PROTEIN SEQUENCE OF 24-383, GLYCOSYLATION AT SER-94; ASN-100; THR-143;SER-163; ASN-165; ASN-172; SER-214; THR-222; SER-251 AND SER-260, ANDVARIANT GLY-101.	7925474 [Abstract]