ANR27_HUMAN - dbPTM
ANR27_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANR27_HUMAN
UniProt AC Q96NW4
Protein Name Ankyrin repeat domain-containing protein 27
Gene Name ANKRD27
Organism Homo sapiens (Human).
Sequence Length 1050
Subcellular Localization Early endosome . Late endosome . Cytoplasmic vesicle membrane . Lysosome . Cell membrane . Melanosome . Colocalizes with VAMP7 in transport vesicles in the shaft of hippocampal neurons (By similarity).
Protein Description May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. [PubMed: 16525121]
Protein Sequence MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANALYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVSQGPEAAGPLSTPQEVSASRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10UbiquitinationLYDEDLLKNPFYLAL
CCCHHHHCCHHHHHH		70.6329967540
107PhosphorylationFYNEKEESFSILCIA
CCCCCCHHEEEEEEE		25.9422210691
122PhosphorylationHPLEKRESSEEPLAP
CCCCCCCCCCCCCCC		47.2727050516
123PhosphorylationPLEKRESSEEPLAPS
CCCCCCCCCCCCCCC		41.0225627689
136UbiquitinationPSDPFSLKTIEDVRE
CCCCCCCCCHHHHHH		46.3829967540
158PhosphorylationRFDRNIASFHRTFRE
HHHHHHHHHHHHHHH		20.1420873877
162PhosphorylationNIASFHRTFRECERK
HHHHHHHHHHHHHHH		20.6230242111
177PhosphorylationSLRHHIDSANALYTK
HHHHHHHHHHHHHHH		23.8724247654
196UbiquitinationLLRDSHLKMLAKQEA
HHHHHHHHHHHHHHH		26.8329967540
200UbiquitinationSHLKMLAKQEAQMNL
HHHHHHHHHHHHHHH		44.72-
215PhosphorylationMKQAVEIYVHHEIYN
HHHHHHHHHHHHHHH		4.7268743127
215UbiquitinationMKQAVEIYVHHEIYN
HHHHHHHHHHHHHHH		4.7222817900
241UbiquitinationSEDAAFNKITRSLQD
CHHHHHHHHHHHHHH		38.7132015554
245PhosphorylationAFNKITRSLQDLQQK
HHHHHHHHHHHHHHC		23.0227067055
252UbiquitinationSLQDLQQKDIGVKPE
HHHHHHHCCCCCCCC		38.0529967540
257UbiquitinationQQKDIGVKPEFSFNI
HHCCCCCCCCHHCCC		33.3530230243
261PhosphorylationIGVKPEFSFNIPRAK
CCCCCCHHCCCHHHH		18.7420873877
276UbiquitinationRELAQLNKCTSPQQK
HHHHHHHCCCCHHHH		47.7029967540
341PhosphorylationYIKNFRFSSLAKDEL
HHHCCCCHHHCCCCH		21.8623403867
342PhosphorylationIKNFRFSSLAKDELG
HHCCCCHHHCCCCHH		29.6323403867
370UbiquitinationRQGSLSAKPPESEGF
HHCCCCCCCCCCCCC		58.7029967540
403UbiquitinationSPTDCLFKHIASGNQ
CHHHHHHHHHHCCCH		22.5829967540
411UbiquitinationHIASGNQKEVERLLS
HHHCCCHHHHHHHHC		68.6621906983
418PhosphorylationKEVERLLSQEDHDKD
HHHHHHHCCCCCCHH		35.7954887155
426PhosphorylationQEDHDKDTVQKMCHP
CCCCCHHHHHHHHCH		30.4930108239
429UbiquitinationHDKDTVQKMCHPLCF
CCHHHHHHHHCHHHC		38.88-
442UbiquitinationCFCDDCEKLVSGRLN
HCCCCHHHHHCCCCC		61.59-
458PhosphorylationPSVVTPFSRDDRGHT
CCCCCCCCCCCCCCC		35.6824667141
468UbiquitinationDRGHTPLHVAAVCGQ
CCCCCCHHHHHHCCC		14.3624816145
567PhosphorylationIGNEKGDTPLHIAAR
ECCCCCCCCEEEHHH		36.1046164139
577PhosphorylationHIAARWGYQGVIETL
EEHHHHCHHHHHHHH		8.6422210691
583PhosphorylationGYQGVIETLLQNGAS
CHHHHHHHHHHCCCC		22.9622210691
598UbiquitinationTEIQNRLKETPLKCA
HHHHHHHHCCCCHHH		57.2029967540
603MethylationRLKETPLKCALNSKI
HHHCCCCHHHHCHHH		20.75-
603UbiquitinationRLKETPLKCALNSKI
HHHCCCCHHHHCHHH		20.7529967540
626"N6,N6-dimethyllysine"LSFERRQKSSEAPVQ
HCHHHHCCCCCCCCC		54.88-
626MethylationLSFERRQKSSEAPVQ
HCHHHHCCCCCCCCC		54.8823644510
634PhosphorylationSSEAPVQSPQRSVDS
CCCCCCCCCCCCHHH		24.2025159151
650PhosphorylationSQESSTSSFSSMSAS
CCCCCCCCCCCCCCC		29.2746164121
664UbiquitinationSSRQEETKKDYREVE
CCCCHHHHHHHHHHH		47.1024816145
733PhosphorylationRLAKVPASGLGVNVT
HHCCCCCCCCCCEEE		28.6023898821
740PhosphorylationSGLGVNVTSQDGSSP
CCCCCEEECCCCCCC		18.5723898821
741PhosphorylationGLGVNVTSQDGSSPL
CCCCEEECCCCCCCH		23.2223898821
745PhosphorylationNVTSQDGSSPLHVAA
EEECCCCCCCHHHHH		36.7523898821
746PhosphorylationVTSQDGSSPLHVAAL
EECCCCCCCHHHHHH		36.6923898821
765UbiquitinationDLIPLLLKHGANAGA
HHHHHHHHCCCCCCC		39.7129967540
805UbiquitinationDSNAKPNKKDLSGNT
HCCCCCCCCCCCCCC		57.0829967540
868PhosphorylationLLLLHGASVQVLNKR
HHHHCCCHHHHCCCC		20.0646164127
887PhosphorylationVDCAEQNSKIMELLQ
HHHHHHHHHHHHHHH		24.2130622161
888UbiquitinationDCAEQNSKIMELLQV
HHHHHHHHHHHHHHH		54.3332015554
925PhosphorylationKIRKKWNSKLYDLPD
EEEHHHCCCCCCCCC		23.9546164133
928PhosphorylationKKWNSKLYDLPDEPF
HHHCCCCCCCCCCCC		21.1225884760
940PhosphorylationEPFTRQFYFVHSAGQ
CCCEEEEEEEECCCC		9.0672248303
944PhosphorylationRQFYFVHSAGQFKGK
EEEEEEECCCCCCCC		28.8829978859
949MethylationVHSAGQFKGKTSREI
EECCCCCCCCCHHHH		52.16-
962PhosphorylationEIMARDRSVPNLTEG
HHHHHCCCCCCCCCC		46.3323401153
967PhosphorylationDRSVPNLTEGSLHEP
CCCCCCCCCCCCCCC		44.9630576142
970PhosphorylationVPNLTEGSLHEPGRQ
CCCCCCCCCCCCCCC		21.9623401153
978PhosphorylationLHEPGRQSVTLRQNN
CCCCCCCEEEEECCC		18.7324719451
980PhosphorylationEPGRQSVTLRQNNLP
CCCCCEEEEECCCCC		22.8224719451
1000PhosphorylationHAAEKGNSDWPERPG
CHHHHCCCCCCCCCC		50.1226434552
1009PhosphorylationWPERPGLTQTGPGHR
CCCCCCCCCCCHHHH		29.9628555341
1023PhosphorylationRRMLRRHTVEDAVVS
HHHHHHCCCCHHHHC		24.6323401153
1030PhosphorylationTVEDAVVSQGPEAAG
CCCHHHHCCCCCCCC		23.8728450419
1040PhosphorylationPEAAGPLSTPQEVSA
CCCCCCCCCCCCHHC		40.9720071362
1041PhosphorylationEAAGPLSTPQEVSAS
CCCCCCCCCCCHHCC		36.3520071362
1048PhosphorylationTPQEVSASRS-----
CCCCHHCCCC-----		26.0820071362
1050PhosphorylationQEVSASRS-------
CCHHCCCC-------		41.9263756875
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANR27_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANR27_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANR27_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RB40A_HUMANRAB40Aphysical
25661869
RB40B_HUMANRAB40Bphysical
25661869
RB40C_HUMANRAB40Cphysical
25661869
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ANR27_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1023, AND MASSSPECTROMETRY.

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