RB40B_HUMAN - dbPTM
RB40B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RB40B_HUMAN
UniProt AC Q12829
Protein Name Ras-related protein Rab-40B
Gene Name RAB40B
Organism Homo sapiens (Human).
Sequence Length 278
Subcellular Localization Cell membrane
Lipid-anchor
Cytoplasmic side .
Protein Description May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
Protein Sequence MSALGSPVRAYDFLLKFLLVGDSDVGKGEILASLQDGAAESPYGHPAGIDYKTTTILLDGRRVKLQLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFDGIDRWIKEIDEHAPGVPKILVGNRLHLAFKRQVPTEQAQAYAERLGVTFFEVSPLCNFNITESFTELARIVLLRHGMDRLWRPSKVLSLQDLCCRAVVSCTPVHLVDKLPLPIALRSHLKSFSMANGLNARMMHGGSYSLTTSSTHKRSSLRKVKLVRPPQSPPKNCTRNSCKIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSALGSPVR
------CCCCCCCCH		32.00-
6Phosphorylation--MSALGSPVRAYDF
--CCCCCCCCHHHHH		22.5226329039
43PhosphorylationDGAAESPYGHPAGID
CCCCCCCCCCCCCCC		37.0327642862
51PhosphorylationGHPAGIDYKTTTILL
CCCCCCCCCCEEEEE		14.3327273156
73UbiquitinationQLWDTSGQGRFCTIF
EEEECCCCCCEEEEE		39.3921890473
93UbiquitinationGAQGVILVYDIANRW
CCCEEEEEEECCCCC		2.5121890473
116UbiquitinationIKEIDEHAPGVPKIL
HHHHHHHCCCCCEEE		10.6521890473
133UbiquitinationNRLHLAFKRQVPTEQ
CCHHHHHHCCCCHHH		35.9921890473
191PhosphorylationWRPSKVLSLQDLCCR
CCHHHCCCHHHHHHC		27.2922210691
224PhosphorylationALRSHLKSFSMANGL
HHHHHHHHHHCCCCC		28.9922210691
226PhosphorylationRSHLKSFSMANGLNA
HHHHHHHHCCCCCCE		24.8722210691
247PhosphorylationSYSLTTSSTHKRSSL
CEECCCCCCCCCCCC		32.22-
265PhosphorylationKLVRPPQSPPKNCTR
EEECCCCCCCCCCCC		49.2826437602
270S-palmitoylationPQSPPKNCTRNSCKI
CCCCCCCCCCCCCCC		4.76-
275GeranylgeranylationKNCTRNSCKIS----
CCCCCCCCCCC----		5.32-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RB40B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RB40B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RB40B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CUL5_HUMANCUL5physical
18187417
ELOB_HUMANTCEB2physical
18187417
ELOC_HUMANTCEB1physical
18187417
A4_HUMANAPPphysical
21832049
BICL2_MOUSECcdc64bphysical
20360680
WFDC1_HUMANWFDC1physical
21988832
ELOC_HUMANTCEB1physical
26186194
CUL5_HUMANCUL5physical
26186194
PGTB2_HUMANRABGGTBphysical
26186194
RB40L_HUMANRAB40ALphysical
26186194
RB40C_HUMANRAB40Cphysical
26186194
ISCA1_HUMANISCA1physical
26186194
DCA17_HUMANDCAF17physical
26186194
FHL3_HUMANFHL3physical
21516116
CUL5_HUMANCUL5physical
28514442
RB40C_HUMANRAB40Cphysical
28514442
PGTB2_HUMANRABGGTBphysical
28514442
RB40L_HUMANRAB40ALphysical
28514442
DCA17_HUMANDCAF17physical
28514442
ELOC_HUMANTCEB1physical
28514442
ISCA1_HUMANISCA1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RB40B_HUMAN

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Related Literatures of Post-Translational Modification

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