MOT8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOT8_HUMAN
• UniProt AC: P36021
• Protein Name: Monocarboxylate transporter 8
• Gene Name: SLC16A2
• Organism: Homo sapiens (Human).
• Sequence Length: 539
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr..
• Protein Sequence: MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNGELLPGSPNPEEPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALQSQASE ------CCCCCCCCH	17.82	22223895
5	Phosphorylation	---MALQSQASEEAK ---CCCCCCCCHHHC	28.67	29514088
8	Phosphorylation	MALQSQASEEAKGPW CCCCCCCCHHHCCCH	28.47	25849741
71	Phosphorylation	LPELEFESERVHEPE CCCCEECCCCCCCCC	35.70	24275569
80	Phosphorylation	RVHEPEPTPTVETRG CCCCCCCCCCEEECC	29.90	30266825
82	Phosphorylation	HEPEPTPTVETRGTA CCCCCCCCEEECCCC	33.19	30266825
85	Phosphorylation	EPTPTVETRGTARGF CCCCCEEECCCCCCC	30.02	30266825
193	Phosphorylation	HTSSFTSSLSLRYFT ECCCCCCCHHHHHHH	20.94	17081983
195	Phosphorylation	SSFTSSLSLRYFTYG CCCCCCHHHHHHHHH	16.85	17081983
267	Phosphorylation	AQTFQVLSTFMFVLM HHHHHHHHHHHHHHH	22.27	17081983
290	Phosphorylation	LLPSSQDTPSKRGVR CCCCCCCCCCCCHHH	23.09	20068230
532	Phosphorylation	NGELLPGSPNPEEPI CCCCCCCCCCCCCCC	21.40	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOT8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOT8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOT8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MOT8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00650: Allan-Herndon-Dudley syndrome; Monocarboxylate transporter 8 deficiency
• OMIM Disease
• 300523: Monocarboxylate transporter 8 deficiency (MCT8 deficiency)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00149: L-Leucine
• DB00150: L-Tryptophan
• DB00135: L-Tyrosine
• DB00451: Levothyroxine
• DB01583: Liotrix
• DB00119: Pyruvic acid

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193 AND SER-195, ANDMASS SPECTROMETRY.
PubMed: 17081983