MLH3_HUMAN - dbPTM
MLH3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MLH3_HUMAN
UniProt AC Q9UHC1
Protein Name DNA mismatch repair protein Mlh3
Gene Name MLH3
Organism Homo sapiens (Human).
Sequence Length 1453
Subcellular Localization Nucleus .
Protein Description Probably involved in the repair of mismatches in DNA..
Protein Sequence MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLEQQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
105PhosphorylationANIADMASAVEISSK
HHHHHHHHHHHHHHC		26.6429978859
110PhosphorylationMASAVEISSKKNRTM
HHHHHHHHHCCCCCH		23.6929978859
111PhosphorylationASAVEISSKKNRTMK
HHHHHHHHCCCCCHH		54.0029978859
128UbiquitinationVKLFQSGKALKACEA
HHHHHHCHHHHHCCC		56.65-
186PhosphorylationSLMHPSISFSLRNDV
HHHCCCEEEEECCCC		17.0824719451
188PhosphorylationMHPSISFSLRNDVSG
HCCCEEEEECCCCCC		21.4524719451
227PhosphorylationSQKLREISFKYKEFE
CHHHHHEEEEECEEE		15.7824719451
236PhosphorylationKYKEFELSGYISSEA
EECEEEEEEECCCEE		23.5030177828
238PhosphorylationKEFELSGYISSEAHY
CEEEEEEECCCEECC		8.3430177828
240PhosphorylationFELSGYISSEAHYNK
EEEEEECCCEECCCC		17.4030177828
241PhosphorylationELSGYISSEAHYNKN
EEEEECCCEECCCCC		29.2830177828
245PhosphorylationYISSEAHYNKNMQFL
ECCCEECCCCCCEEE		34.5730177828
380UbiquitinationLFDATLQKRVTSDER
CCHHHHHHHCCCCCC		52.53-
414UbiquitinationQSKAVKRKTTAENVN
CCHHHHCCCCCCCCC		44.50-
415PhosphorylationSKAVKRKTTAENVNT
CHHHHCCCCCCCCCC		34.9630631047
416PhosphorylationKAVKRKTTAENVNTQ
HHHHCCCCCCCCCCC		34.7030631047
422PhosphorylationTTAENVNTQSSRDSE
CCCCCCCCCCCCCCH		26.0830631047
424PhosphorylationAENVNTQSSRDSEAT
CCCCCCCCCCCCHHH		25.88-
425PhosphorylationENVNTQSSRDSEATR
CCCCCCCCCCCHHHH		30.23-
428PhosphorylationNTQSSRDSEATRKNT
CCCCCCCCHHHHHHC		28.2030631047
435PhosphorylationSEATRKNTNDAFLYI
CHHHHHHCCCEEEEE		37.1925954137
443PhosphorylationNDAFLYIYESGGPGH
CCEEEEEEECCCCCC		7.1825954137
445PhosphorylationAFLYIYESGGPGHSK
EEEEEEECCCCCCCC		31.8825954137
454PhosphorylationGPGHSKMTEPSLQNK
CCCCCCCCCHHHCCC		48.7825954137
605PhosphorylationYGRVKLCSTGFITHV
CCCEEEECCCCEEEE		41.8428555341
606PhosphorylationGRVKLCSTGFITHVV
CCEEEECCCCEEEEE		34.8122817900
610PhosphorylationLCSTGFITHVVQNEK
EECCCCEEEEEECCC		13.3222817900
619UbiquitinationVVQNEKTKSTETEHS
EEECCCCCCCCCCCH		67.46-
628UbiquitinationTETEHSFKNYVRPGP
CCCCCHHCCCCCCCC		50.84-
649PhosphorylationFGNRTRHSVETPDIK
HCCCCCCCCCCCCHH		20.5424719451
656UbiquitinationSVETPDIKDLASTLS
CCCCCCHHHHHHHHH		54.81-
664UbiquitinationDLASTLSKESGQLPN
HHHHHHHHHHCCCCC		60.04-
666PhosphorylationASTLSKESGQLPNKK
HHHHHHHHCCCCCCC		35.2628555341
681PhosphorylationNCRTNISYGLENEPT
CCCCCCCCCCCCCCC		23.18-
690PhosphorylationLENEPTATYTMFSAF
CCCCCCCCEEEEHHH		23.23-
691PhosphorylationENEPTATYTMFSAFQ
CCCCCCCEEEEHHHH		8.17-
746PhosphorylationPIVRKKLSLSSQLGS
HHHHHHCCHHHHHCC		34.7825159151
748PhosphorylationVRKKLSLSSQLGSLE
HHHHCCHHHHHCCHH		16.8029978859
749PhosphorylationRKKLSLSSQLGSLEK
HHHCCHHHHHCCHHH		34.4229978859
753PhosphorylationSLSSQLGSLEKFKRQ
CHHHHHCCHHHHHHH		41.7829978859
845PhosphorylationCLEQQMPSLRESPMT
HHHHCCHHHHHCCCC		34.4124719451
876UbiquitinationSSESLASKLSRLKGS
CHHHHHHHHHHHCCC		44.89-
881AcetylationASKLSRLKGSERETQ
HHHHHHHCCCHHHHH		60.3219815731
883PhosphorylationKLSRLKGSERETQTM
HHHHHCCCHHHHHHH		31.7124719451
946PhosphorylationDSATQDNSFNKNSKT
CCCCCCCCCCCCCCC		38.1928555341
982UbiquitinationNNSKVTGKDSDVLIR
CCCCCCCCCCCEEEE		44.70-
982AcetylationNNSKVTGKDSDVLIR
CCCCCCCCCCCEEEE		44.7026051181
1062PhosphorylationMVYVNKMTGLSTFIA
EEEEEECCCCCCEEC		36.26-
1083PhosphorylationAACTKDLTTVAVDVV
HHHCCCCCEEEEEEE		29.3828509920
1084PhosphorylationACTKDLTTVAVDVVL
HHCCCCCEEEEEEEE		17.4828509920
1095PhosphorylationDVVLENGSQYRCQPF
EEEEECCCEEECCCC		35.3028509920
1097PhosphorylationVLENGSQYRCQPFRS
EEECCCEEECCCCCC		18.3028509920
1128PhosphorylationMRQDNRDTVDDTVSS
CCCCCCCCCCCCCCH		23.69-
1162PhosphorylationEVAVDVSSGQAESLA
CEEEECCCCCCHHHH		34.4722468782
1177PhosphorylationVKIHNILYPYRFTKG
HHCCEEHHHHHCCCC		8.4022468782
1182PhosphorylationILYPYRFTKGMIHSM
EHHHHHCCCCHHHHH		20.0729396449
1188PhosphorylationFTKGMIHSMQVLQQV
CCCCHHHHHHHHHHC		10.4529396449
1208PhosphorylationACLMSTKTEENGEAG
HHHHCCCCCCCCCCC		48.93-
1216 (in isoform 2)Phosphorylation-28.7626471730
1243UbiquitinationLIIDSYEKQQAQGSG
HHHHHHHHHHHCCCC		39.20-
1256PhosphorylationSGRKKLLSSTLIPPL
CCCCHHHHCCCCCCE		31.5424114839
1257PhosphorylationGRKKLLSSTLIPPLE
CCCHHHHCCCCCCEE		27.4824114839
1258PhosphorylationRKKLLSSTLIPPLEI
CCHHHHCCCCCCEEE		25.9024114839
1413UbiquitinationIDHLEQEKQIKPNLT
CHHHHHHHCCCCCHH		57.95-
1446PhosphorylationTRQSLQQSMPPCEPP
HHHHHHHCCCCCCCC		21.9429978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MLH3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MLH3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MLH3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MLH1_HUMANMLH1physical
11292842
MSH4_HUMANMSH4physical
12095912
FAN1_HUMANFAN1physical
20603073
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614385Hereditary non-polyposis colorectal cancer 7 (HNPCC7)
114500Colorectal cancer (CRC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MLH3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-606 AND THR-610, ANDMASS SPECTROMETRY.

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