FAN1_HUMAN - dbPTM
FAN1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FAN1_HUMAN
UniProt AC Q9Y2M0
Protein Name Fanconi-associated nuclease 1 {ECO:0000303|PubMed:20603015, ECO:0000303|PubMed:20603016, ECO:0000303|PubMed:20671156}
Gene Name FAN1 {ECO:0000303|PubMed:20603015}
Organism Homo sapiens (Human).
Sequence Length 1017
Subcellular Localization Nucleus . Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ-type zinc finger (PubMed:20935496).
Protein Description Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. [PubMed: 20603015]
Protein Sequence MMSEGKPPDKKRPRRSLSISKNKKKASNSIISCFNNAPPAKLACPVCSKMVPRYDLNRHLDEMCANNDFVQVDPGQVGLINSNVSMVDLTSVTLEDVTPKKSPPPKTNLTPGQSDSAKREVKQKISPYFKSNDVVCKNQDELRNRSVKVICLGSLASKLSRKYVKAKKSIDKDEEFAGSSPQSSKSTVVKSLIDNSSEIEDEDQILENSSQKENVFKCDSLKEECIPEHMVRGSKIMEAESQKATRECEKSALTPGFSDNAIMLFSPDFTLRNTLKSTSEDSLVKQECIKEVVEKREACHCEEVKMTVASEAKIQLSDSEAKSHSSADDASAWSNIQEAPLQDDSCLNNDIPHSIPLEQGSSCNGPGQTTGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQRSVCTWGKNKPGIGAVILKRAKALAGQSVRICKGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVKHVTITGRLCPQRGMCKSVFVMEAGEAADPTTVLCSVEELALAHYRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAVGAKSQSLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MMSEGKPPDK
-----CCCCCCCCCC		55.8728509920
16PhosphorylationDKKRPRRSLSISKNK
CCCCCCHHCCCCCCC		27.9624719451
18PhosphorylationKRPRRSLSISKNKKK
CCCCHHCCCCCCCHH		26.5124719451
20PhosphorylationPRRSLSISKNKKKAS
CCHHCCCCCCCHHHC		27.1428102081
102PhosphorylationEDVTPKKSPPPKTNL
HHCCCCCCCCCCCCC		49.0924719451
110PhosphorylationPPPKTNLTPGQSDSA
CCCCCCCCCCCCHHH		27.6925159151
114PhosphorylationTNLTPGQSDSAKREV
CCCCCCCCHHHHHHH		39.1727251275
116PhosphorylationLTPGQSDSAKREVKQ
CCCCCCHHHHHHHHH		40.7225159151
126PhosphorylationREVKQKISPYFKSND
HHHHHHHCHHHHCCC		22.1525159151
128PhosphorylationVKQKISPYFKSNDVV
HHHHHCHHHHCCCEE		19.4923186163
131PhosphorylationKISPYFKSNDVVCKN
HHCHHHHCCCEEECC		28.5022964224
137UbiquitinationKSNDVVCKNQDELRN
HCCCEEECCHHHHHH		46.14-
146PhosphorylationQDELRNRSVKVICLG
HHHHHHCCEEEEEHH		29.82-
154PhosphorylationVKVICLGSLASKLSR
EEEEEHHHHHHHHHH		14.0728555341
160PhosphorylationGSLASKLSRKYVKAK
HHHHHHHHHHHHHHH		30.3924719451
163PhosphorylationASKLSRKYVKAKKSI
HHHHHHHHHHHHHCC		13.1824719451
169PhosphorylationKYVKAKKSIDKDEEF
HHHHHHHCCCCCHHH		35.0029396449
179PhosphorylationKDEEFAGSSPQSSKS
CCHHHCCCCCCCCCH		35.1029396449
180PhosphorylationDEEFAGSSPQSSKST
CHHHCCCCCCCCCHH		26.4925159151
183PhosphorylationFAGSSPQSSKSTVVK
HCCCCCCCCCHHHHH		43.0229396449
184PhosphorylationAGSSPQSSKSTVVKS
CCCCCCCCCHHHHHH		25.9429396449
191PhosphorylationSKSTVVKSLIDNSSE
CCHHHHHHHCCCCCC		20.9623403867
196PhosphorylationVKSLIDNSSEIEDED
HHHHCCCCCCCCCHH		26.1223403867
197PhosphorylationKSLIDNSSEIEDEDQ
HHHCCCCCCCCCHHH		49.1723403867
209PhosphorylationEDQILENSSQKENVF
HHHHHCCCCCCCCEE		25.4423401153
210PhosphorylationDQILENSSQKENVFK
HHHHCCCCCCCCEEE		57.7823403867
251PhosphorylationATRECEKSALTPGFS
HHHHHHHHCCCCCCC		13.2523532336
254PhosphorylationECEKSALTPGFSDNA
HHHHHCCCCCCCCCE		22.5324719451
258PhosphorylationSALTPGFSDNAIMLF
HCCCCCCCCCEEEEE		35.55-
270PhosphorylationMLFSPDFTLRNTLKS
EEECCCEEHHHHCCC		31.9924719451
276UbiquitinationFTLRNTLKSTSEDSL
EEHHHHCCCCCCCHH		50.0429967540
317PhosphorylationSEAKIQLSDSEAKSH
CEEEEECCCHHHHCC		23.7925159151
319PhosphorylationAKIQLSDSEAKSHSS
EEEECCCHHHHCCCC		35.7630001349
493UbiquitinationLVNPNGQKQQLVDAF
CCCCCCHHHHHHHHH		41.22-
502UbiquitinationQLVDAFLKLAKQRSV
HHHHHHHHHHHHCCC		39.69-
516UbiquitinationVCTWGKNKPGIGAVI
CCCCCCCCCCHHHHH		48.3729967540
592UbiquitinationPSYTINRKTHIFQDR
CEEEECCCCEEECCH		39.71-
628UbiquitinationNGNWEEAKELAQCAK
CCCHHHHHHHHHHHH		57.45-
635UbiquitinationKELAQCAKRDWNRLK
HHHHHHHHHHHHHHC		59.5229967540
646PhosphorylationNRLKNHPSLRCHEDL
HHHCCCCCCCCCCCH		22.3924719451
692PhosphorylationEAVRELESLLSQRIY
HHHHHHHHHHHCCCC		47.4324719451
695PhosphorylationRELESLLSQRIYCPD
HHHHHHHHCCCCCCC		23.7824719451
720UbiquitinationLNLHQHLKRLEPTIK
HHHHHHHHHHHHHHH		53.46-
727UbiquitinationKRLEPTIKCITEGLA
HHHHHHHHHHHCCCC		23.28-
795PhosphorylationPQRGMCKSVFVMEAG
CCCCCCCEEEEEECC		18.8329978859
808PhosphorylationAGEAADPTTVLCSVE
CCCCCCCCEEEEEHH		30.0429978859
809PhosphorylationGEAADPTTVLCSVEE
CCCCCCCEEEEEHHH		19.5029978859
813PhosphorylationDPTTVLCSVEELALA
CCCEEEEEHHHHHHH		28.5329978859
822PhosphorylationEELALAHYRRSGFDQ
HHHHHHHHHHHCCCC		11.3429978859
977UbiquitinationHFKLVEVKGPNDRLS
CEEEEEECCCCCCCC		55.96-
986UbiquitinationPNDRLSHKQMIWLAE
CCCCCCHHHHHHHHH		37.8829967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FAN1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FAN1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FAN1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MLH1_HUMANMLH1physical
20603073
MLH3_HUMANMLH3physical
20603073
PMS1_HUMANPMS1physical
20603073
PMS2_HUMANPMS2physical
20603073
FACD2_HUMANFANCD2physical
20603016
FACD2_HUMANFANCD2physical
20603015
FAN1_HUMANFAN1physical
20603015
FANCI_HUMANFANCIphysical
20603015
PMS2_HUMANPMS2physical
20603015
PMS1_HUMANPMS1physical
20603015
IMB1_HUMANKPNB1physical
20603015
MLH1_HUMANMLH1physical
20603015
FANCG_HUMANFANCGphysical
20603015
RFC3_HUMANRFC3physical
20603015
RFC4_HUMANRFC4physical
20603015
PCNA_HUMANPCNAphysical
20603015
1433E_HUMANYWHAEphysical
20603015
1433Z_HUMANYWHAZphysical
20603015
UBC_HUMANUBCphysical
20603015
UBC_HUMANUBCphysical
20935496
AP2A2_HUMANAP2A2physical
26496610
ANXA7_HUMANANXA7physical
26496610
HEXA_HUMANHEXAphysical
26496610
MLH1_HUMANMLH1physical
26496610
P3C2B_HUMANPIK3C2Bphysical
26496610
PMS1_HUMANPMS1physical
26496610
PMS2_HUMANPMS2physical
26496610
2AAA_HUMANPPP2R1Aphysical
26496610
PSD11_HUMANPSMD11physical
26496610
SPT5H_HUMANSUPT5Hphysical
26496610
CAVN2_HUMANSDPRphysical
26496610
ARK72_HUMANAKR7A2physical
26496610
PRP4B_HUMANPRPF4Bphysical
26496610
TRAP1_HUMANTRAP1physical
26496610
ANKL2_HUMANANKLE2physical
26496610
MIER1_HUMANMIER1physical
26496610
NCOA5_HUMANNCOA5physical
26496610
C99L2_HUMANCD99L2physical
26496610
WDR75_HUMANWDR75physical
26496610
PKHA8_HUMANPLEKHA8physical
26496610
CA052_HUMANC1orf52physical
26496610
H3C_HUMANH3F3Cphysical
26496610
MLH1_HUMANMLH1physical
27880917
OTUD4_HUMANOTUD4physical
27880917
PMS1_HUMANPMS1physical
27880917
PMS2_HUMANPMS2physical
27880917
ZN703_HUMANZNF703physical
27880917
FAN1_HUMANFAN1physical
27432908
TCP4_HUMANSUB1physical
27432908
AROS_HUMANRPS19BP1physical
27432908
NUD16_HUMANNUDT16physical
27432908
RL36L_HUMANRPL36ALphysical
27432908
G45IP_HUMANGADD45GIP1physical
27432908
HPBP1_HUMANHSPBP1physical
27432908
FBLI1_HUMANFBLIM1physical
27432908
NOP16_HUMANNOP16physical
27432908
LA_HUMANSSBphysical
27432908
RBM34_HUMANRBM34physical
27432908
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FAN1_HUMAN

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Related Literatures of Post-Translational Modification

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