CAVN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAVN2_HUMAN
• UniProt AC: O95810
• Protein Name: Caveolae-associated protein 2 {ECO:0000312|HGNC:HGNC:10690}
• Gene Name: CAVIN2 {ECO:0000312|HGNC:HGNC:10690}
• Organism: Homo sapiens (Human).
• Sequence Length: 425
• Subcellular Localization: Cytoplasm, cytosol . Membrane, caveola . Localizes in the caveolae in a caveolin-dependent manner.
• Protein Description: Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. [PubMed: 19525939 Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity]
• Protein Sequence: MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQVHQTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGEDAAQAE ------CCHHHHHHH		-
10	Ubiquitination	EDAAQAEKFQHPGSD HHHHHHHHHCCCCCH		23000965
16	Phosphorylation	EKFQHPGSDMRQEKP HHHCCCCCHHCCCCC		28060719
24	Phosphorylation	DMRQEKPSSPSPMPS HHCCCCCCCCCCCCC		23401153
25	Phosphorylation	MRQEKPSSPSPMPSS HCCCCCCCCCCCCCC		23927012
27	Phosphorylation	QEKPSSPSPMPSSTP CCCCCCCCCCCCCCC		23401153
31	Phosphorylation	SSPSPMPSSTPSPSL CCCCCCCCCCCCCCC		23927012
32	Phosphorylation	SPSPMPSSTPSPSLN CCCCCCCCCCCCCCC		23927012
33	Phosphorylation	PSPMPSSTPSPSLNL CCCCCCCCCCCCCCC		23927012
35	Phosphorylation	PMPSSTPSPSLNLGN CCCCCCCCCCCCCCC		23927012
37	Phosphorylation	PSSTPSPSLNLGNTE CCCCCCCCCCCCCHH		23927012
43	Phosphorylation	PSLNLGNTEEAIRDN CCCCCCCHHHHHHCC		23403867
51	Phosphorylation	EEAIRDNSQVNAVTV HHHHHCCCCCCHHHH		28270605
57	Phosphorylation	NSQVNAVTVLTLLDK CCCCCHHHHHHHHHH		28270605
60	Phosphorylation	VNAVTVLTLLDKLVN CCHHHHHHHHHHHHH		28270605
85	Phosphorylation	KMEQRQISLEGSVKG HHHHHHHHHHHHHHH		25072903
89	Phosphorylation	RQISLEGSVKGIQND HHHHHHHHHHHHHCC		25072903
91	Ubiquitination	ISLEGSVKGIQNDLT HHHHHHHHHHHCCHH		23000965
99	Ubiquitination	GIQNDLTKLSKYQAS HHHCCHHHHHHHHHH		23000965
101	Phosphorylation	QNDLTKLSKYQASTS HCCHHHHHHHHHHCC		18491316
102	Ubiquitination	NDLTKLSKYQASTSN CCHHHHHHHHHHCCH		23000965
103	Phosphorylation	DLTKLSKYQASTSNT CHHHHHHHHHHCCHH		29116813
107	Phosphorylation	LSKYQASTSNTVSKL HHHHHHHCCHHHHHH		29116813
112	Phosphorylation	ASTSNTVSKLLEKSR HHCCHHHHHHHHHHH		22817900
113	Ubiquitination	STSNTVSKLLEKSRK HCCHHHHHHHHHHHH		23000965
117	Ubiquitination	TVSKLLEKSRKVSAH HHHHHHHHHHHHHHH		23000965
156	Ubiquitination	LLRRNHFKVLIFQEE HHHHCCCEEEEEECC		33845483
169	Phosphorylation	EENEIPASVFVKQPV CCCCCCCEEEEECCC		28060719
173	Ubiquitination	IPASVFVKQPVSGAV CCCEEEEECCCCCCC		33845483
177	Phosphorylation	VFVKQPVSGAVEGKE EEEECCCCCCCCCCC		24505115
183	Ubiquitination	VSGAVEGKEELPDEN CCCCCCCCCCCCCCC		33845483
192	Phosphorylation	ELPDENKSLEETLHT CCCCCCCCHHHHHHH		20058876
196	Phosphorylation	ENKSLEETLHTVDLS CCCCHHHHHHHCCCC		24972180
199	Phosphorylation	SLEETLHTVDLSSDD CHHHHHHHCCCCCCC		24972180
203	Phosphorylation	TLHTVDLSSDDDLPH HHHHCCCCCCCCCCC		20058876
204	Phosphorylation	LHTVDLSSDDDLPHD HHHCCCCCCCCCCCC		20058876
218	Phosphorylation	DEEALEDSAEEKVEE CHHHHHHHHHHHHHH		20058876
226	Phosphorylation	AEEKVEESRAEKIKR HHHHHHHHHHHHHHH		28060719
241	Phosphorylation	SSLKKVDSLKKAFSR HHHHHHHHHHHHHHH		26657352
247	Phosphorylation	DSLKKAFSRQNIEKK HHHHHHHHHHHHHHH		23403867
257	Ubiquitination	NIEKKMNKLGTKIVS HHHHHHHHHCCCEEH		23000965
260	Phosphorylation	KKMNKLGTKIVSVER HHHHHHCCCEEHHHH		-
261	Ubiquitination	KMNKLGTKIVSVERR HHHHHCCCEEHHHHH		23000965
264	Phosphorylation	KLGTKIVSVERREKI HHCCCEEHHHHHHHH		28060719
274	Phosphorylation	RREKIKKSLTSNHQK HHHHHHHHHHCCCCC		29691806
276	Phosphorylation	EKIKKSLTSNHQKIS HHHHHHHHCCCCCCC		22798277
283	Phosphorylation	TSNHQKISSGKSSPF HCCCCCCCCCCCCCC		23403867
284	Phosphorylation	SNHQKISSGKSSPFK CCCCCCCCCCCCCCC		23401153
286	Ubiquitination	HQKISSGKSSPFKVS CCCCCCCCCCCCCCC		23000965
287	Phosphorylation	QKISSGKSSPFKVSP CCCCCCCCCCCCCCC		23401153
288	Phosphorylation	KISSGKSSPFKVSPL CCCCCCCCCCCCCCC		23401153
291	Ubiquitination	SGKSSPFKVSPLTFG CCCCCCCCCCCCCCC		23000965
293	Phosphorylation	KSSPFKVSPLTFGRK CCCCCCCCCCCCCCH		26846344
296	Phosphorylation	PFKVSPLTFGRKKVR CCCCCCCCCCCHHCC		30266825
307	Phosphorylation	KKVREGESHAENETK HHCCCCCCCCCCCCC		27535140
313	Phosphorylation	ESHAENETKSEDLPS CCCCCCCCCCCCCCC		24275569
320	Phosphorylation	TKSEDLPSSEQMPND CCCCCCCCCCCCCCH		20058876
321	Phosphorylation	KSEDLPSSEQMPNDQ CCCCCCCCCCCCCHH		20058876
332	Phosphorylation	PNDQEEESFAEGHSE CCHHHHHHHHHCCCH		27251275
338	Phosphorylation	ESFAEGHSEASLASA HHHHHCCCHHHHHHH		27251275
341	Phosphorylation	AEGHSEASLASALVE HHCCCHHHHHHHHHH		24275569
344	Phosphorylation	HSEASLASALVEGEI CCHHHHHHHHHHHHH		27251275
360	Phosphorylation	EEAAEKATSRGSNSG HHHHHHHHHCCCCCC		22617229
361	Phosphorylation	EAAEKATSRGSNSGM HHHHHHHHCCCCCCC		23403867
364	Phosphorylation	EKATSRGSNSGMDSN HHHHHCCCCCCCCCC		30266825
366	Phosphorylation	ATSRGSNSGMDSNID HHHCCCCCCCCCCCC		30266825
370	Phosphorylation	GSNSGMDSNIDLTIV CCCCCCCCCCCEEEE		22617229
375	Phosphorylation	MDSNIDLTIVEDEEE CCCCCCEEEECCCHH		26657352
384	Phosphorylation	VEDEEEESVALEQAQ ECCCHHHHHHHHHHH		26657352
395	Phosphorylation	EQAQKVRYEGSYALT HHHHHHCCCCCEECC		23927012
398	Phosphorylation	QKVRYEGSYALTSEE HHHCCCCCEECCHHH		23927012
399	Phosphorylation	KVRYEGSYALTSEEA HHCCCCCEECCHHHH		23927012
402	Phosphorylation	YEGSYALTSEEAERS CCCCEECCHHHHHHC		23927012
403	Phosphorylation	EGSYALTSEEAERSD CCCEECCHHHHHHCC		23927012
409	Phosphorylation	TSEEAERSDGDPVQP CHHHHHHCCCCCCCC		28192239
424	Phosphorylation	AVLQVHQTS------ CEEEEECCC------		28060719
425	Phosphorylation	VLQVHQTS------- EEEEECCC-------		28060719

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAVN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAVN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAVN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUD18_HUMAN	NUDT18	physical	16189514
PKHF2_HUMAN	PLEKHF2	physical	16189514
CAVN2_HUMAN	SDPR	physical	25416956
A1CF_HUMAN	A1CF	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.