TOX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOX_HUMAN
• UniProt AC: O94900
• Protein Name: Thymocyte selection-associated high mobility group box protein TOX
• Gene Name: TOX
• Organism: Homo sapiens (Human).
• Sequence Length: 526
• Subcellular Localization: Nucleus .
• Protein Description: May play a role in regulating T-cell development..
• Protein Sequence: MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWNNDYCSSGGMQRDKALYLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MDVRFYPPPAQ ----CCCCCCCCCCC	22.55	115383807
65	Phosphorylation	YPGPSLESEDFNIPP CCCCCCCCCCCCCCC	48.00	26074081
74	Phosphorylation	DFNIPPITPPSLPDH CCCCCCCCCCCCCCC	34.61	26074081
77	Phosphorylation	IPPITPPSLPDHSLV CCCCCCCCCCCCCEE	54.46	26074081
82	Phosphorylation	PPSLPDHSLVHLNEV CCCCCCCCEEEHHHC	39.19	26074081
147	Phosphorylation	DIRNPEGTQYSSHPQ CCCCCCCCCCCCCHH	23.75	28796482
149	Phosphorylation	RNPEGTQYSSHPQMA CCCCCCCCCCCHHHH	16.39	28796482
150	Phosphorylation	NPEGTQYSSHPQMAA CCCCCCCCCCHHHHH	16.62	28796482
151	Phosphorylation	PEGTQYSSHPQMAAM CCCCCCCCCHHHHHC	33.96	28796482
212	Phosphorylation	PSPPGSKSATPSPSS CCCCCCCCCCCCCCC	38.79	30576142
214	Phosphorylation	PPGSKSATPSPSSSV CCCCCCCCCCCCCCC	31.24	30576142
216	Phosphorylation	GSKSATPSPSSSVHE CCCCCCCCCCCCCCC	32.81	28192239
218	Phosphorylation	KSATPSPSSSVHEDE CCCCCCCCCCCCCCC	39.31	30576142
219	Phosphorylation	SATPSPSSSVHEDEG CCCCCCCCCCCCCCC	39.50	30576142
220	Phosphorylation	ATPSPSSSVHEDEGD CCCCCCCCCCCCCCC	31.65	30576142
229	Phosphorylation	HEDEGDDTSKINGGE CCCCCCCCCCCCCCC	36.34	30576142
230	Phosphorylation	EDEGDDTSKINGGEK CCCCCCCCCCCCCCC	38.23	30108239
237	Acetylation	SKINGGEKRPASDMG CCCCCCCCCCHHHCC	67.94	25953088
245	Acetylation	RPASDMGKKPKTPKK CCHHHCCCCCCCCCC	60.30	2520169
246	Acetylation	PASDMGKKPKTPKKK CHHHCCCCCCCCCCC	46.12	2520177
252	Acetylation	KKPKTPKKKKKKDPN CCCCCCCCCCCCCCC	71.65	7289899
266	Phosphorylation	NEPQKPVSAYALFFR CCCCCCCEEEEEEEH	24.88	28555341
280	Ubiquitination	RDTQAAIKGQNPNAT HHHHHHHCCCCCCCC	50.12	29967540
293	Ubiquitination	ATFGEVSKIVASMWD CCHHHHHHHHHHHCC	46.50	29967540
307	Ubiquitination	DGLGEEQKQVYKKKT CCCCHHHHHHHHHHH	45.04	29967540
335	Ubiquitination	YRASLVSKSYSEPVD HHHHHHCCCCCCCCC	46.03	29967540
336	Phosphorylation	RASLVSKSYSEPVDV HHHHHCCCCCCCCCC	26.78	28796482
337	Phosphorylation	ASLVSKSYSEPVDVK HHHHCCCCCCCCCCC	22.31	28796482
338	O-linked_Glycosylation	SLVSKSYSEPVDVKT HHHCCCCCCCCCCCC	42.38	28657654
338	Phosphorylation	SLVSKSYSEPVDVKT HHHCCCCCCCCCCCC	42.38	-
344	Ubiquitination	YSEPVDVKTSQPPQL CCCCCCCCCCCCCCH	37.69	29967540
416	Phosphorylation	SIANMAVSPPPPLQI EEECCCCCCCCCCCC	23.35	26074081
424	Phosphorylation	PPPPLQISPPLHQHL CCCCCCCCCCHHHHC	13.91	26074081
492	Phosphorylation	VVTQAMEYVRSGCRN HHHHHHHHHHHCCCC	6.51	-
495	Phosphorylation	QAMEYVRSGCRNPPP HHHHHHHHCCCCCCC	32.00	26552605
511	Phosphorylation	PVDWNNDYCSSGGMQ CCCCCCCCCCCCCCC	9.06	28796482
513	Phosphorylation	DWNNDYCSSGGMQRD CCCCCCCCCCCCCCC	26.28	28796482
514	Phosphorylation	WNNDYCSSGGMQRDK CCCCCCCCCCCCCCC	35.49	26552605
526	Phosphorylation	RDKALYLT------- CCCEEEEC-------	24.02	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOX_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TOX_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.