NPFF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPFF_HUMAN
• UniProt AC: O15130
• Protein Name: Pro-FMRFamide-related neuropeptide FF
• Gene Name: NPFF
• Organism: Homo sapiens (Human).
• Sequence Length: 113
• Subcellular Localization: Secreted.
• Protein Description: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels..
• Protein Sequence: MDSRQAAALLVLLLLIDGGCAEGPGGQQEDQLSAEEDSEPLPPQDAQTSGSLLHYLLQAMERPGRSQAFLFQPQRFGRNTQGSWRNEWLSPRAGEGLNSQFWSLAAPQRFGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phenylalanine amide	FLFQPQRFGRNTQGS EEECCCCCCCCCCCC	10.18	-
76	Amidation	FLFQPQRFGRNTQGS EEECCCCCCCCCCCC	10.18	-
110	Phenylalanine amide	SLAAPQRFGKK---- HHHCCHHHCCC----	16.51	-
110	Amidation	SLAAPQRFGKK---- HHHCCHHHCCC----	16.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPFF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPFF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPFF_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NPFF_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.