VSX2_HUMAN - dbPTM
VSX2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VSX2_HUMAN
UniProt AC P58304
Protein Name Visual system homeobox 2
Gene Name VSX2
Organism Homo sapiens (Human).
Sequence Length 361
Subcellular Localization Nucleus.
Protein Description Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity)..
Protein Sequence MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGHLLAARSVLSPAGVGGMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEGERQALPKLDKMEQDERGPDAQAAISQEELRENSIAVLRAKAQEHSTKVLGTVSGPDSLARSTEKPEEEEAMDEDRPAERLSPPQLEDMA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationGKAGEALSKPKSETV
CCHHHHCCCCCCCCC		54.6924719451
219PhosphorylationRSSVMAEYGLYGAMV
CHHHHHHHCHHHHHH		11.68-
222PhosphorylationVMAEYGLYGAMVRHS
HHHHHCHHHHHHHCC		9.85-
235PhosphorylationHSIPLPESILKSAKD
CCCCCCHHHHHHCCC		31.1424719451
266PhosphorylationSLEAAAESGRKPEGE
HHHHHHHHCCCCCCH		38.89-
297PhosphorylationPDAQAAISQEELREN
CCHHHHHCHHHHHHC		27.15-
305PhosphorylationQEELRENSIAVLRAK
HHHHHHCCHHHHHHH		13.74-
317PhosphorylationRAKAQEHSTKVLGTV
HHHHHHHCCEEEEEC		29.2129978859
318PhosphorylationAKAQEHSTKVLGTVS
HHHHHHCCEEEEECC		27.3829978859
323PhosphorylationHSTKVLGTVSGPDSL
HCCEEEEECCCHHHH		13.8229978859
325PhosphorylationTKVLGTVSGPDSLAR
CEEEEECCCHHHHCC		44.4329978859
329PhosphorylationGTVSGPDSLARSTEK
EECCCHHHHCCCCCC		27.3629978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VSX2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VSX2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VSX2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WDR20_HUMANWDR20physical
26186194
CHM1A_HUMANCHMP1Aphysical
26186194
WDR48_HUMANWDR48physical
26186194
CSK22_HUMANCSNK2A2physical
26186194
CSK21_HUMANCSNK2A1physical
26186194
UBP20_HUMANUSP20physical
26186194
UBP33_HUMANUSP33physical
26186194
UBP12_HUMANUSP12physical
26186194
SAHH3_HUMANAHCYL2physical
26186194
CR025_HUMANC18orf25physical
26186194
ZN703_HUMANZNF703physical
26186194
UBP20_HUMANUSP20physical
28514442
UBP12_HUMANUSP12physical
28514442
WDR20_HUMANWDR20physical
28514442
CHM1A_HUMANCHMP1Aphysical
28514442
UBP33_HUMANUSP33physical
28514442
CSK22_HUMANCSNK2A2physical
28514442
SAHH3_HUMANAHCYL2physical
28514442
ZN703_HUMANZNF703physical
28514442
CSK21_HUMANCSNK2A1physical
28514442
PARP2_HUMANPARP2physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VSX2_HUMAN

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Related Literatures of Post-Translational Modification

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