TIGD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIGD1_HUMAN
• UniProt AC: Q96MW7
• Protein Name: Tigger transposable element-derived protein 1
• Gene Name: TIGD1
• Organism: Homo sapiens (Human).
• Sequence Length: 591
• Subcellular Localization: Nucleus .
• Protein Sequence: MASKCSSERKSRTSLTLNQKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVNAKEKFLKEVKSATPMNTRMIRKRNSLIADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLFNSMKAERGVEAAEEKFEASRGWFMRFKERSHFHNIKAQGEAASADVEAAASYPEALAKIIDEGGYTKQQIFNVDETAFYWKKMPSRTFIAREEKSVPGFKASKDRLTLLLGANAAGDFKLKPMLIYHSENPRALKNYTKSTLPVLYKWNSKARMTAHLFTAWFTEYFKPTVETYCSEKKIPFKILLLIDNAPSHPRALMEIYEEINVIFMPANTTSILQPMDQGVISTFKSYYLRNTFHKALAAMDSDVSDGSGQSKLKTFWKGFTILDAIKNIRDSWEEVKLSTLTGVWKKLIPTLIDDYEGFKTSVEEVSADVVEIAKELELEVEPEDVTELLQSHDKTLTDEELFLMDAQRKWFLEMESTPGEDAVNIVEMTTKDLEYYINLVDKAAAGFERIDSNFERSSTVGKMLSNSIACYREIFHERKSQLMRKASPMSYFRKLPQPPQPSAATTLTSQQPSTSRQDPPPAKRVRLTEGSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	KCSSERKSRTSLTLN CCCCCCCCCCCCCHH	47.19	18452278
13	Phosphorylation	SSERKSRTSLTLNQK CCCCCCCCCCCHHHH	34.87	18452278
14	Phosphorylation	SERKSRTSLTLNQKL CCCCCCCCCCHHHHH	20.46	25159151
33	Ubiquitination	LSEEGMSKAEIGRRL CCHHCCCHHHHHHHH	40.94	29967540
54	Ubiquitination	VSQVVNAKEKFLKEV HHHHHHHHHHHHHHH	57.12	-
56	Ubiquitination	QVVNAKEKFLKEVKS HHHHHHHHHHHHHHH	56.12	-
62	Sumoylation	EKFLKEVKSATPMNT HHHHHHHHHCCCCCH	35.15	-
62	Sumoylation	EKFLKEVKSATPMNT HHHHHHHHHCCCCCH	35.15	-
77	Phosphorylation	RMIRKRNSLIADMEK HHHHHHCCHHHHHHH	25.78	24719451
108	Ubiquitination	SQSLIQNKALTLFNS CHHHHHHHHHHHHHH	28.53	-
115	Phosphorylation	KALTLFNSMKAERGV HHHHHHHHHHHHHHH	17.83	-
117	Sumoylation	LTLFNSMKAERGVEA HHHHHHHHHHHHHHH	47.09	-
117	Sumoylation	LTLFNSMKAERGVEA HHHHHHHHHHHHHHH	47.09	-
128	Ubiquitination	GVEAAEEKFEASRGW HHHHHHHHHHHCCCC	39.76	29967540
165	Phosphorylation	DVEAAASYPEALAKI CHHHHHHCHHHHHHH	10.60	28555341
178	Phosphorylation	KIIDEGGYTKQQIFN HHHHCCCCCCEEEEC	22.94	22210691
179	Phosphorylation	IIDEGGYTKQQIFNV HHHCCCCCCEEEECC	26.17	22210691
213	Ubiquitination	EKSVPGFKASKDRLT CCCCCCCCCCHHHHH	58.63	29967540
216	Ubiquitination	VPGFKASKDRLTLLL CCCCCCCHHHHHHHH	52.29	-
241	Phosphorylation	KPMLIYHSENPRALK CCEEEECCCCHHHHH	23.30	27251275
366	Phosphorylation	DSDVSDGSGQSKLKT CCCCCCCCCCHHHHH	38.35	26714015
370	Ubiquitination	SDGSGQSKLKTFWKG CCCCCCHHHHHHHHC	46.22	29967540
385	Ubiquitination	FTILDAIKNIRDSWE HHHHHHHHHHHHCHH	48.30	-
395	Ubiquitination	RDSWEEVKLSTLTGV HHCHHHHHHHHHHHH	39.74	29967540
405	Ubiquitination	TLTGVWKKLIPTLID HHHHHHHHHHHHHHH	35.62	29967540
488	Phosphorylation	AVNIVEMTTKDLEYY CEEEEEEEHHHHHHH	19.72	18669648
495	Phosphorylation	TTKDLEYYINLVDKA EHHHHHHHHHHHHHH	3.64	22817900
518	Phosphorylation	SNFERSSTVGKMLSN CCCCCHHHHHHHHHH	34.23	28787133
546	Phosphorylation	SQLMRKASPMSYFRK HHHHHHHCCCHHHHC	24.95	22617229
553	Ubiquitination	SPMSYFRKLPQPPQP CCCHHHHCCCCCCCC	55.40	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIGD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIGD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIGD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.