dbPTM

GP135_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GP135_HUMAN
UniProt AC	Q8IZ08
Protein Name	G-protein coupled receptor 135 {ECO:0000305}
Gene Name	GPR135
Organism	Homo sapiens (Human).
Sequence Length	494
Subcellular Localization	Cell membrane Multi-pass membrane protein . Endosome membrane Multi-pass membrane protein . Colocalizes with ARRB2/beta-arrestin-2 in the endosome.
Protein Description	Orphan receptor. Has spontaneous activity for beta-arrestin recruitment. [PubMed: 28827538 Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization]
Protein Sequence	MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSFSTVATAALGNLSDASGGGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAAVAAQALVLLLIFLLSSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGRNREEGYRTRNVDAFLPSQGPGLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTAVTKQPKSEAGDTSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
325	Phosphorylation	ARVLRFFSEVRTATT HHHHHHHHHHHHHHH	32.25	24719451
445	Phosphorylation	LGACNRMSSSNPASG HCHHHHCCCCCCCCC	27.64	-
446	Phosphorylation	GACNRMSSSNPASGV CHHHHCCCCCCCCCC	25.45	-
447	Phosphorylation	ACNRMSSSNPASGVA HHHHCCCCCCCCCCC	39.25	-
483	Ubiquitination	EPVTAVTKQPKSEAG CCCEEEECCCCCCCC	58.99	-
486	Ubiquitination	TAVTKQPKSEAGDTS EEEECCCCCCCCCCC	59.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GP135_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GP135_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GP135_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GP135_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GP135_HUMAN

Related Literatures of Post-Translational Modification