ZN597_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN597_HUMAN
• UniProt AC: Q96LX8
• Protein Name: Zinc finger protein 597
• Gene Name: ZNF597
• Organism: Homo sapiens (Human).
• Sequence Length: 424
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTKESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLVPYPEKSSEDGVGNPEAKILSGTPTYKRRVISLLVTIENHTPLVELSEYLGTNTLSEILDSPWEGAKNVYKCPECDQNFSDHSYLVLHQKIHSGEKKHKCGDCGKIFNHRANLRTHRRIHTGEKPYKCAKCSASFRQHSHLSRHMNSHVKEKPYTCSICGRGFMWLPGLAQHQKSHSAENTYESTNCDKHFNEKPNLALPEETFVSGPQYQHTKCMKSFRQSLYPALSEKSHDEDSERCSDDGDNFFSFSKFKPLQCPDCDMTFPCFSELISHQNIHTEERPHKCKTCEESFALDSELACHQKSHMLAEPFKCTVCGKTFKSNLHLITHKRTHIKNTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASMPPTPEA -----CCCCCCCCCC	30.44	21214269
22	Phosphorylation	LFEDLAVYFSQEECV EEEHHEEEECHHHHH	7.60	21214269
92	Ubiquitination	PLVPYPEKSSEDGVG CCCCCCCCCCCCCCC	55.57	-
104	Ubiquitination	GVGNPEAKILSGTPT CCCCCCCCCCCCCCC	42.38	29967540
107	Phosphorylation	NPEAKILSGTPTYKR CCCCCCCCCCCCHHH	44.06	30001349
109	Phosphorylation	EAKILSGTPTYKRRV CCCCCCCCCCHHHHH	14.74	25159151
111	Phosphorylation	KILSGTPTYKRRVIS CCCCCCCCHHHHHHH	41.32	30001349
207	Phosphorylation	RTHRRIHTGEKPYKC HHCCCCCCCCCCCCC	44.67	29496963
210	Ubiquitination	RRIHTGEKPYKCAKC CCCCCCCCCCCCCCC	55.80	22505724
263	Phosphorylation	AQHQKSHSAENTYES HHHHHCCCCCCCHHC	44.35	28985074
289	Phosphorylation	NLALPEETFVSGPQY CCCCCHHHCCCCCCC	27.89	-
299	Phosphorylation	SGPQYQHTKCMKSFR CCCCCCHHHHHHHHH	15.48	-
300	Sumoylation	GPQYQHTKCMKSFRQ CCCCCHHHHHHHHHH	30.15	28112733
317	Phosphorylation	YPALSEKSHDEDSER HHHHCCCCCCCCHHH	31.92	19664994
322	Phosphorylation	EKSHDEDSERCSDDG CCCCCCCHHHCCCCC	25.54	23663014
326	Phosphorylation	DEDSERCSDDGDNFF CCCHHHCCCCCCCCC	44.98	30266825
334	Phosphorylation	DDGDNFFSFSKFKPL CCCCCCCCHHHCCCC	25.19	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN597_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN597_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN597_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN597_HUMAN	ZNF597	physical	20211142
SMC6_HUMAN	SMC6	physical	26186194
NSE2_HUMAN	NSMCE2	physical	26186194
MPP8_HUMAN	MPHOSPH8	physical	26186194
NSE3_HUMAN	NDNL2	physical	26186194
SMC5_HUMAN	SMC5	physical	26186194
F208B_HUMAN	FAM208B	physical	26186194
NSE1_HUMAN	NSMCE1	physical	26186194
PPHLN_HUMAN	PPHLN1	physical	26186194
NSE4A_HUMAN	NSMCE4A	physical	26186194
MPP8_HUMAN	MPHOSPH8	physical	28514442
SMC5_HUMAN	SMC5	physical	28514442
NSE2_HUMAN	NSMCE2	physical	28514442
F208B_HUMAN	FAM208B	physical	28514442
SMC6_HUMAN	SMC6	physical	28514442
NSE1_HUMAN	NSMCE1	physical	28514442
NSE4A_HUMAN	NSMCE4A	physical	28514442
NSE3_HUMAN	NDNL2	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.