TMTC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMTC1_HUMAN
• UniProt AC: Q8IUR5
• Protein Name: Transmembrane and TPR repeat-containing protein 1
• Gene Name: TMTC1
• Organism: Homo sapiens (Human).
• Sequence Length: 882
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RGGGGDRTPSRRRGC CCCCCCCCCCCCCCC	30.29	29759185
113	Phosphorylation	LTGMNPFYFHAVNII HHCCCHHHHHHHHHH	8.84	24043423
126	Phosphorylation	IILHCLVTLVLMYTC HHHHHHHHHHHHHHC	9.75	24043423
131	Phosphorylation	LVTLVLMYTCDKTVF HHHHHHHHHCCCHHH	10.47	24043423
132	Phosphorylation	VTLVLMYTCDKTVFK HHHHHHHHCCCHHHH	10.56	24043423
184	N-linked_Glycosylation	LLAFLSYNRSLDQGC HHHHHHCCCCCCCCC	24.56	UniProtKB CARBOHYD
244	Phosphorylation	LSNKQDKSSNGALCP CCCCCCCCCCCCCCC	37.01	-
245	Phosphorylation	SNKQDKSSNGALCPR CCCCCCCCCCCCCCC	45.05	-
253	Phosphorylation	NGALCPRSPQQPGSP CCCCCCCCCCCCCCC	16.53	20873877
259	Phosphorylation	RSPQQPGSPQPSSLP CCCCCCCCCCCCCCC	27.35	27732954
263	Phosphorylation	QPGSPQPSSLPGHPH CCCCCCCCCCCCCCC	38.98	27732954
264	Phosphorylation	PGSPQPSSLPGHPHR CCCCCCCCCCCCCCC	45.31	27732954
304	Phosphorylation	KSSGFPVSPRAVWSM CCCCCCCCHHHHHHH	14.65	28555341
414	Phosphorylation	VVAERVLYMPSMGYC HHHEHHHCCCCCCCH	12.24	22817900
420	Phosphorylation	LYMPSMGYCILFVHG HCCCCCCCHHHHHCH	2.80	22817900
518	Phosphorylation	KLYPRHASALNNLGT HHCHHHHHHHHHCCC	27.45	22210691
569	Phosphorylation	EKKEEAITLLKDSIK HHHHHHHHHHHHHHH	32.84	-
615	Phosphorylation	GIKNCPDSSDLHNNY CCCCCCCCHHHCCCC	15.76	28348404
616	Phosphorylation	IKNCPDSSDLHNNYG CCCCCCCHHHCCCCE	52.12	28348404
622	Phosphorylation	SSDLHNNYGVFLVDT CHHHCCCCEEEEEEC	21.71	28348404
629	Phosphorylation	YGVFLVDTGLPEKAV CEEEEEECCCCHHHH	32.89	28348404
660	Phosphorylation	MVNLGRLYRSLGENS HHHHHHHHHHHCCCC	9.22	24043423
687	Phosphorylation	AHKAEILSPLGALYY HHHHHHHHHCHHHHH	24.60	24043423
696	Phosphorylation	LGALYYNTGRYEEAL CHHHHHCCCCHHHHH	13.60	-
740	Phosphorylation	TKEAEKMTNHIVSEE CHHHHHHHHHHHCCC	34.41	-
745	Phosphorylation	KMTNHIVSEETGCLE HHHHHHHCCCCCHHH	29.16	29759185
839	Phosphorylation	IQHIKGKYVSARAYY HHHHCCCEEEHHHHH	14.33	22210691
841	Phosphorylation	HIKGKYVSARAYYER HHCCCEEEHHHHHHH	14.67	22210691
846	Phosphorylation	YVSARAYYERALQLV EEEHHHHHHHHHHHC	9.65	22210691
856	Phosphorylation	ALQLVPDSKLLKENL HHHHCCCHHHHHHHH	21.09	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMTC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMTC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMTC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMTC1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.