dbPTM

ADT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADT4_HUMAN
UniProt AC	Q9H0C2
Protein Name	ADP/ATP translocase 4
Gene Name	SLC25A31
Organism	Homo sapiens (Human).
Sequence Length	315
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein. Cell projection, cilium, flagellum. In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.
Protein Description	Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility..
Protein Sequence	MHREPAKKKAEKRLFDASSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRASYFGAYDTVKGLLPKPKKTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSGEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGTGGALVLVLYDKIKEFFHIDIGGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	EKRLFDASSFGKDLL HHHHHCHHHHCHHHH	28.22	20068231
19	Phosphorylation	KRLFDASSFGKDLLA HHHHCHHHHCHHHHH	39.47	20068231
34	Phosphorylation	GGVAAAVSKTAVAPI HHHHHHCCCCCCCCH	21.40	20068231
36	Phosphorylation	VAAAVSKTAVAPIER HHHHCCCCCCCCHHH	20.89	20860994
45	Ubiquitination	VAPIERVKLLLQVQA CCCHHHHHHHHHHHC	39.37	22817900
53	Phosphorylation	LLLQVQASSKQISPE HHHHHHCCCCCCCHH	22.45	30622161
54	Phosphorylation	LLQVQASSKQISPEA HHHHHCCCCCCCHHH	31.43	30622161
58	Phosphorylation	QASSKQISPEARYKG HCCCCCCCHHHHHCC	17.75	21659604
63	Phosphorylation	QISPEARYKGMVDCL CCCHHHHHCCHHHEE	20.95	-
93	Phosphorylation	NLANVIRYFPTQALN CHHHHHHHCHHHHHH	11.64	24927040
96	Phosphorylation	NVIRYFPTQALNFAF HHHHHCHHHHHHHHC	19.30	21712546
104	Acetylation	QALNFAFKDKYKQLF HHHHHHCHHHHHHHH	50.29	6570043
104	Ubiquitination	QALNFAFKDKYKQLF HHHHHHCHHHHHHHH	50.29	22817900
106	Acetylation	LNFAFKDKYKQLFMS HHHHCHHHHHHHHHH	55.74	7617841
106	Ubiquitination	LNFAFKDKYKQLFMS HHHHCHHHHHHHHHH	55.74	22817900
108	Ubiquitination	FAFKDKYKQLFMSGV HHCHHHHHHHHHHCC	46.39	22817900
113	Phosphorylation	KYKQLFMSGVNKEKQ HHHHHHHHCCCHHHH	32.05	20068231
117	Ubiquitination	LFMSGVNKEKQFWRW HHHHCCCHHHHHHHH	64.97	-
218	Acetylation	KGLLPKPKKTPFLVS HCCCCCCCCCCHHHH	75.34	19824391
219	Acetylation	GLLPKPKKTPFLVSF CCCCCCCCCCHHHHH	70.70	19824399
220	Phosphorylation	LLPKPKKTPFLVSFF CCCCCCCCCHHHHHH	25.96	22210691
261	Phosphorylation	SGEAKRQYKGTLDCF CCHHHHHHCCCHHHE	18.54	-
264	Phosphorylation	AKRQYKGTLDCFVKI HHHHHCCCHHHEEEH	18.44	-
270	Acetylation	GTLDCFVKIYQHEGI CCHHHEEEHHHCCCH	18.55	25038526
279	Phosphorylation	YQHEGISSFFRGAFS HHCCCHHHHHHHHHH	26.87	24719451
303	Acetylation	LVLVLYDKIKEFFHI EEEEEHHHHHHHHCC	41.96	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ADT4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ADT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ADT4_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ADT4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-104, AND MASS SPECTROMETRY.	19608861 [Abstract]