GABP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GABP2_HUMAN
• UniProt AC: Q8TAK5
• Protein Name: GA-binding protein subunit beta-2
• Gene Name: GABPB2
• Organism: Homo sapiens (Human).
• Sequence Length: 448
• Subcellular Localization: Nucleus.
• Protein Description: May function as transcription factor capable of interacting with purine rich repeats (GA repeats)..
• Protein Sequence: MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTRVSMATVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLVDLGKR ------CCHHHHHHH	36.78	27251275
8	Ubiquitination	MSLVDLGKRLLEAAR CCHHHHHHHHHHHHH	47.36	-
138	Ubiquitination	HAFSKFDKSAFDIAL HEECCCCHHHHHHHH	46.98	-
199	O-linked_Glycosylation	VNLASLISSTNTKTT EEHHHHHHCCCCCCC	36.08	29485866
201	O-linked_Glycosylation	LASLISSTNTKTTSG HHHHHHCCCCCCCCC	39.87	29485866
205	O-linked_Glycosylation	ISSTNTKTTSGDPHA HHCCCCCCCCCCCCC	24.93	29485866
207	O-linked_Glycosylation	STNTKTTSGDPHAST CCCCCCCCCCCCCEE	46.56	29485866
222	O-linked_Glycosylation	VQFSNSTTSVLATLA EEECCCHHHHHHHHH	19.36	29485866
256	Phosphorylation	EEIIEGNSVDSSIQQ HHHHCCCCCCHHHHH	37.85	27251275
323	Sumoylation	VAEETVIKEEEEEKL EEEEEECCHHHHHCC	55.53	-
323	Sumoylation	VAEETVIKEEEEEKL EEEEEECCHHHHHCC	55.53	-
341	Acetylation	KKPRIGEKTNSVEES CCCCCCCCCCCHHHC	48.03	25953088
342	Phosphorylation	KPRIGEKTNSVEESK CCCCCCCCCCHHHCC	28.55	28111955
344	Phosphorylation	RIGEKTNSVEESKEG CCCCCCCCHHHCCCC	35.82	24719451
431	Phosphorylation	RETKVTGSAGTTEPH CEEEECCCCCCCCCC	17.73	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GABP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GABP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GABP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RYBP_HUMAN	RYBP	physical	11953439
KDM1A_HUMAN	KDM1A	physical	23455924
GABPA_HUMAN	GABPA	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.