TMC6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMC6_HUMAN
• UniProt AC: Q7Z403
• Protein Name: Transmembrane channel-like protein 6
• Gene Name: TMC6
• Organism: Homo sapiens (Human).
• Sequence Length: 805
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Probable ion channel..
• Protein Sequence: MAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQCTAQEGLELQQREREVTGSSQQTLWRPEGTQSTATLRILASMPSRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKRSLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCITLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQAAVLGLVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQEAVLLVLPLVVGLLNLGAPYLCRVLAALEPHDSPVLEVYVAICRNLILKLAILGTLCYHWLGRRVGVLQGQCWEDFVGQELYRFLVMDFVLMLLDTLFGELVWRIISEKKLKRRRKPEFDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLVFYVKKTSLLANCQAPRRPWLASHMSTVFLTLLCFPAFLGAAVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEAAGPRVSWLPWVHRYLMENTFFVFLVSALLLAVIYLNIQVVRGQRKVICLLKEQISNEGEDKIFLINKLHSIYERKEREERSRVGTTEEAAAPPALLTDEQDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48 (in isoform 3)	Ubiquitination	-	64.38	21906983
60	Phosphorylation	QQREREVTGSSQQTL HHHHHHHCCCCCCEE	26.96	30108239
62	Phosphorylation	REREVTGSSQQTLWR HHHHHCCCCCCEEEC	18.66	30108239
63	Phosphorylation	EREVTGSSQQTLWRP HHHHCCCCCCEEECC	27.87	30108239
66	Phosphorylation	VTGSSQQTLWRPEGT HCCCCCCEEECCCCC	22.20	30108239
73	Phosphorylation	TLWRPEGTQSTATLR EEECCCCCCCHHHHH	20.06	23312004
75	Phosphorylation	WRPEGTQSTATLRIL ECCCCCCCHHHHHHH	21.61	23312004
76	Phosphorylation	RPEGTQSTATLRILA CCCCCCCHHHHHHHH	17.53	23312004
78	Phosphorylation	EGTQSTATLRILASM CCCCCHHHHHHHHCC	19.36	23312004
84	Phosphorylation	ATLRILASMPSRTIG HHHHHHHCCCCCCCC	27.99	28355574
87	Phosphorylation	RILASMPSRTIGRSR HHHHCCCCCCCCCCC	33.15	30108239
89	Phosphorylation	LASMPSRTIGRSRGA HHCCCCCCCCCCCCC	31.92	25219547
93	Phosphorylation	PSRTIGRSRGAIISQ CCCCCCCCCCCHHHH	29.83	25219547
94	Methylation	SRTIGRSRGAIISQY CCCCCCCCCCHHHHH	36.88	24129315
99	Phosphorylation	RSRGAIISQYYNRTV CCCCCHHHHHCCCCE	13.15	25219547
101	Phosphorylation	RGAIISQYYNRTVQL CCCHHHHHCCCCEEE	8.91	25219547
102	Phosphorylation	GAIISQYYNRTVQLR CCHHHHHCCCCEEEE	7.19	25219547
103	N-linked_Glycosylation	AIISQYYNRTVQLRC CHHHHHCCCCEEEEC	28.36	UniProtKB CARBOHYD
105	Phosphorylation	ISQYYNRTVQLRCRS HHHHCCCCEEEECCC	14.68	25219547
112	Phosphorylation	TVQLRCRSSRPLLGN CEEEECCCCCCCCHH	34.03	26657352
113	Phosphorylation	VQLRCRSSRPLLGNF EEEECCCCCCCCHHH	20.68	26657352
123	Phosphorylation	LLGNFVRSAWPSLRL CCHHHHHHHCCCCEE	29.41	28450419
127	Phosphorylation	FVRSAWPSLRLYDLE HHHHHCCCCEEEEEE	18.54	30108239
131	Phosphorylation	AWPSLRLYDLELDPT HCCCCEEEEEECCHH	16.43	27642862
145 (in isoform 2)	Ubiquitination	-	48.76	21906983
145 (in isoform 1)	Ubiquitination	-	48.76	21906983
145	Ubiquitination	TALEEEEKQSLLVKE HCCCHHHHHHHHHHH	48.76	21906983
151	Ubiquitination	EKQSLLVKELQSLAV HHHHHHHHHHHHHHH	53.31	21906983
151 (in isoform 2)	Ubiquitination	-	53.31	21906983
151 (in isoform 1)	Ubiquitination	-	53.31	21906983
175	Ubiquitination	MPLSLAEKRSLREKS CCCCHHHHHHHHHHC	41.50	-
182 (in isoform 4)	Ubiquitination	-	36.31	21906983
312	N-linked_Glycosylation	MYYGHYSNATLNQPC HHHCCCCCCCCCCCC	29.76	UniProtKB CARBOHYD
349 (in isoform 3)	Ubiquitination	-	3.81	21906983
406	Phosphorylation	LQQDNIRTRLKELLA HHHHCHHHHHHHHHH	36.23	-
409 (in isoform 1)	Ubiquitination	-	42.92	21906983
409	Ubiquitination	DNIRTRLKELLAEWQ HCHHHHHHHHHHHHH	42.92	21906983
419 (in isoform 2)	Ubiquitination	-	51.23	21906983
420	Phosphorylation	AEWQLRHSPRSVCGR HHHHHHCCCHHHHHH	18.64	17081983
575	Phosphorylation	ELVWRIISEKKLKRR HHHHHHHCHHHHHHC	40.78	24719451
584	Ubiquitination	KKLKRRRKPEFDIAR HHHHHCCCCHHHHHH	47.27	-
626	Phosphorylation	IKLLLVFYVKKTSLL HHHHHHHHHHHHCHH	12.13	30622161
748	Ubiquitination	QVVRGQRKVICLLKE HHHCCCCCEEEEEEH	28.23	-
754	Ubiquitination	RKVICLLKEQISNEG CCEEEEEEHHHCCCC	34.32	-
764	Ubiquitination	ISNEGEDKIFLINKL HCCCCCCCEEHHHHH	30.93	-
770	Ubiquitination	DKIFLINKLHSIYER CCEEHHHHHHHHHHH	40.35	2190698
770 (in isoform 1)	Ubiquitination	-	40.35	21906983
773	Phosphorylation	FLINKLHSIYERKER EHHHHHHHHHHHHHH	36.98	25003641
775	Phosphorylation	INKLHSIYERKEREE HHHHHHHHHHHHHHH	16.82	-
778	Acetylation	LHSIYERKEREERSR HHHHHHHHHHHHHHC	49.54	7378631

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMC6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMC6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMC6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PXK_HUMAN	PXK	physical	28514442
CBARP_HUMAN	C19orf26	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00842: Epidermodysplasia verruciformis
• OMIM Disease
• 226400: Epidermodysplasia verruciformis (EV)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, AND MASSSPECTROMETRY.
PubMed: 17081983