| UniProt ID | SL9A9_HUMAN | |
|---|---|---|
| UniProt AC | Q8IVB4 | |
| Protein Name | Sodium/hydrogen exchanger 9 | |
| Gene Name | SLC9A9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 645 | |
| Subcellular Localization |
Late endosome membrane Multi-pass membrane protein . |
|
| Protein Description | May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.. | |
| Protein Sequence | MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDAAAFFQSVGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQEANNLDKNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAYGEQLKEDDVECIVNQDELAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEGDLGLGGYELKLEQTLGQSQLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | ERQSRVMSEKDEYQF CCCCCCCCCCCCHHH | 38.34 | 24719451 | |
| 96 | N-linked_Glycosylation | SPSTLLVNITDQVYE CCCEEEEECHHHHHH | 31.26 | 17660510 | |
| 148 | Phosphorylation | PIIFHAGYSLKKRHF HHHHHCCCCCHHHHH | 16.18 | - | |
| 149 | Phosphorylation | IIFHAGYSLKKRHFF HHHHCCCCCHHHHHH | 32.56 | 24719451 | |
| 355 | Phosphorylation | YTYNNLSSDSKIRTK HCCCCCCCCCCCCHH | 49.41 | - | |
| 463 | Phosphorylation | QPKQMMFTTTLLLVF CHHHHHHHHHHHHHH | 10.85 | 24043423 | |
| 464 | Phosphorylation | PKQMMFTTTLLLVFF HHHHHHHHHHHHHHH | 12.27 | 24043423 | |
| 465 | Phosphorylation | KQMMFTTTLLLVFFT HHHHHHHHHHHHHHH | 16.61 | 24043423 | |
| 472 | Phosphorylation | TLLLVFFTVWVFGGG HHHHHHHHHHHHCCC | 11.29 | 24043423 | |
| 480 | Phosphorylation | VWVFGGGTTPMLTWL HHHHCCCCCCCCHHH | 30.88 | 24043423 | |
| 481 | Phosphorylation | WVFGGGTTPMLTWLQ HHHCCCCCCCCHHHH | 15.24 | 24043423 | |
| 485 | Phosphorylation | GGTTPMLTWLQIRVG CCCCCCCHHHHEEEC | 20.20 | 24043423 | |
| 500 | Ubiquitination | VDLDENLKEDPSSQH CCCCCCCCCCCCHHH | 72.20 | - | |
| 530 | Phosphorylation | ARLFRMWYSFDHKYL HHHHHHHHHCCCCCH | 7.07 | - | |
| 591 | Phosphorylation | QDELAINYQEQASSP HHHHHCCHHHHCCCC | 13.81 | 28270605 | |
| 596 | Phosphorylation | INYQEQASSPCSPPA CCHHHHCCCCCCCCH | 34.21 | 28270605 | |
| 597 | Phosphorylation | NYQEQASSPCSPPAR CHHHHCCCCCCCCHH | 32.70 | 28270605 | |
| 600 | Phosphorylation | EQASSPCSPPARLGL HHCCCCCCCCHHCCC | 36.98 | 28270605 | |
| 610 | Ubiquitination | ARLGLDQKASPQTPG HHCCCCCCCCCCCCC | 50.96 | 32142685 | |
| 612 | Phosphorylation | LGLDQKASPQTPGKE CCCCCCCCCCCCCCC | 25.28 | 30108239 | |
| 615 | Phosphorylation | DQKASPQTPGKENIY CCCCCCCCCCCCCCC | 37.08 | 24400094 | |
| 622 | Phosphorylation | TPGKENIYEGDLGLG CCCCCCCCCCCCCCC | 25.99 | 28796482 | |
| 631 | Phosphorylation | GDLGLGGYELKLEQT CCCCCCCEEEEEEEE | 19.11 | 28796482 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SL9A9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SL9A9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SL9A9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SL9A9_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| q21). The inversion disrupts DOCK3 and SLC9A9. | Note=A chromosomal aberration involving SLC9A9 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14 | |||||
| 613410 | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, AND MASS SPECTROMETRY. | |
