F135B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F135B_HUMAN
• UniProt AC: Q49AJ0
• Protein Name: Protein FAM135B
• Gene Name: FAM135B
• Organism: Homo sapiens (Human).
• Sequence Length: 1406
• Protein Sequence: MSEIQGTVEFSVELHKFYNVDLFQRGYYQIRVTLKVSSRIPHRLSASIAGQTESSSLHSACVHDSTVHSRVFQILYRNEEVPINDAVVFRVHLLLGGERMEDALSEVDFQLKVDLHFTDSEQQLRDVAGAPMVSSRTLGLHFHPRNGLHHQVPVMFDYFHLSVISVTVHAALVALQQPLISFTRPGRGSWLGKGGPDTGQEQSIISLENLVFGAGYCKPTSSEGSFYITSENCMQHAHKWHRDLCLLLLHAYRGLRLHFLVIMRDIPELPHTELEALAVEETLSQLCSELQMLNNPEKIAEQISKDLAWLTSHMMTLWTQFLDTVTLHSQVTTYLTQEHHTLRVRRFSEAFFYMEHQKLAVLTFQENLIQTHSQLSLDIRNSEYLTSMPPLPAECLDIDGDWNTLPVIFEDRYVDCPATGHNLSVYPNFDVPVTSPTIMNLKDKEDNCMVNSNLSFREDLVLSTIKPSQMDSDEEVIRCPEPGENVATQNHMDMCSESQVYISIGEFQNKAGVPEDECWTGQTSDAGTYPVADVDTSRRSPGPEDGQAPVLTYIDVKSSNKNPSRAEPLVAFNAQHESRSSRDKYGLDRTGLSKVVVGGSHQNAISSDKTTLHELSTLGKGIDQEGKMVLLSLKLTPSEPCDPLSSTLREPLDIRSSLKDSHTEEQEELSVLSGVIKRSSSIISDSGIESEPSSVAWSEARSRALELPSDREVLHPFVRRHALHRNSLEGGHTESNTSLPSGIQASLTSISSLPFEEDEREVALTKLTKSVSAPHISSPEEAAEDADTKQQDGGFAEPSDMHSKSQGSPGSCSQLCGDSGTDAGADHPLVEIVLDADNQQGPGYIDIPKGKGKQFDAQGHCLPDGRTENTPGVETKGLNLKIPRVIALENPRTRSLHRALEETPKGMPKDLNVGQQALSNSGISEVEGLSQHQVPELSCTSAADAINRNSTGQQSQSGSPCIMDDTAFNRGVNAFPEAKHKAGTVCPTVTHSVHSQVLKNQELKAGTSIMGSHLTSAETFTLDSLKAVEVVNLSVSCTATCLPFSSVPKETPARAGFSSKQTLFPITHQPLGSFGVVSTHSSTLDEEVSERMFSFYQAKEKFKKELKIEGFLYSDLTVLASDIPYFPPEEEEENLEDGIHLVVCVHGLDGNSADLRLVKTFIELGLPGGKLDFLMSEKNQMDTFADFDTMTDRLLDEIIQHIQLYNLSISRISFIGHSLGNIIIRSVLTRPRFRYYLNKLHTFLSLSGPHLGTLYNNSTLVSTGLWLMQKLKKSGSLLQLTFRDNADLRKCFLYQLSQKTGLQYFKNVVLVASPQDRYVPFHSARIEMCKTALKDRHTGPVYAEMINNLLGPLVEAKDCTLIRHNVFHALPNTANTLIGRAAHIAVLDSELFLEKFFLVAGLNYFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	DLFQRGYYQIRVTLK EEECCCEEEEEEEEE	10.57	-
37	Phosphorylation	IRVTLKVSSRIPHRL EEEEEEECCCCCCCE	16.59	-
38	Phosphorylation	RVTLKVSSRIPHRLS EEEEEECCCCCCCEE	36.90	-
45	Phosphorylation	SRIPHRLSASIAGQT CCCCCCEEEECCCCC	21.67	-
442	Ubiquitination	SPTIMNLKDKEDNCM CCCCCCCCCCCCCEE	62.85	32015554
442	Sumoylation	SPTIMNLKDKEDNCM CCCCCCCCCCCCCEE	62.85	-
442	Sumoylation	SPTIMNLKDKEDNCM CCCCCCCCCCCCCEE	62.85	-
455	Phosphorylation	CMVNSNLSFREDLVL EEECCCCCCCCCEEE	26.89	24719451
468	Phosphorylation	VLSTIKPSQMDSDEE EEEECCHHHCCCCCC	32.89	24043423
472	Phosphorylation	IKPSQMDSDEEVIRC CCHHHCCCCCCEECC	41.39	24043423
523	Phosphorylation	DECWTGQTSDAGTYP HHCCCCCCCCCCCEE	29.89	30576142
529	Phosphorylation	QTSDAGTYPVADVDT CCCCCCCEEEECCCC	8.52	30576142
537	Phosphorylation	PVADVDTSRRSPGPE EEECCCCCCCCCCCC	22.64	30576142
540	Phosphorylation	DVDTSRRSPGPEDGQ CCCCCCCCCCCCCCC	32.85	23403867
611	Phosphorylation	AISSDKTTLHELSTL CCCCCCCCHHHHHHC	31.68	21712546
632	Phosphorylation	EGKMVLLSLKLTPSE CCCEEEEEEECCCCC	21.21	24719451
656	Phosphorylation	REPLDIRSSLKDSHT CCCCCHHHHCCCCCC	40.12	21949786
657	Phosphorylation	EPLDIRSSLKDSHTE CCCCHHHHCCCCCCH	29.59	21949786
679	Phosphorylation	LSGVIKRSSSIISDS HHHHHHHCCCCCCCC	24.36	27251275
680	Phosphorylation	SGVIKRSSSIISDSG HHHHHHCCCCCCCCC	29.59	27251275
681	Phosphorylation	GVIKRSSSIISDSGI HHHHHCCCCCCCCCC	25.78	27251275
684	Phosphorylation	KRSSSIISDSGIESE HHCCCCCCCCCCCCC	24.85	27251275
686	Phosphorylation	SSSIISDSGIESEPS CCCCCCCCCCCCCCC	34.57	27251275
768	Phosphorylation	EVALTKLTKSVSAPH HHHHHHHHHCCCCCC	23.88	27461979
770	Phosphorylation	ALTKLTKSVSAPHIS HHHHHHHCCCCCCCC	18.97	27461979
772	Phosphorylation	TKLTKSVSAPHISSP HHHHHCCCCCCCCCH	43.08	25307156
777	Phosphorylation	SVSAPHISSPEEAAE CCCCCCCCCHHHHHH	36.48	27251275
778	Phosphorylation	VSAPHISSPEEAAED CCCCCCCCHHHHHHH	35.41	27461979
788	Phosphorylation	EAAEDADTKQQDGGF HHHHHCCCCCCCCCC	32.26	27461979
893	Phosphorylation	IALENPRTRSLHRAL EEECCCCHHHHHHHH	26.35	25278378
895	Phosphorylation	LENPRTRSLHRALEE ECCCCHHHHHHHHHH	28.10	25278378
903	Phosphorylation	LHRALEETPKGMPKD HHHHHHHCCCCCCCC	22.41	-
966	Phosphorylation	SPCIMDDTAFNRGVN CCCCCCCHHHHCCCC	28.96	-
1089	Phosphorylation	STLDEEVSERMFSFY CCCCHHHHHHHHHHH	23.82	-
1189	Phosphorylation	DTFADFDTMTDRLLD CCHHCHHHHHHHHHH	23.20	-
1191	Phosphorylation	FADFDTMTDRLLDEI HHCHHHHHHHHHHHH	21.76	-
1208	Phosphorylation	HIQLYNLSISRISFI HHHHHCCCHHHEEEC	18.19	24719451
1294	Phosphorylation	DLRKCFLYQLSQKTG HHHHHHHHHHHHHHC	6.27	25072903
1297	Phosphorylation	KCFLYQLSQKTGLQY HHHHHHHHHHHCCHH	17.69	25072903
1300	Phosphorylation	LYQLSQKTGLQYFKN HHHHHHHHCCHHCCC	35.17	25072903
1304	Phosphorylation	SQKTGLQYFKNVVLV HHHHCCHHCCCEEEE	22.89	25072903
1373	Phosphorylation	VFHALPNTANTLIGR HHHHCCCCHHHHHHH	21.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F135B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F135B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F135B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT5_HUMAN	KAT5	physical	16169070
ZDH17_HUMAN	ZDHHC17	physical	26186194
ZDH17_HUMAN	ZDHHC17	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.