dbPTM

FUT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FUT2_HUMAN
UniProt AC	Q10981
Protein Name	Galactoside 2-alpha-L-fucosyltransferase 2
Gene Name	FUT2
Organism	Homo sapiens (Human).
Sequence Length	343
Subcellular Localization	Golgi apparatus, Golgi stack membrane Single-pass type II membrane protein. Membrane-bound form in trans cisternae of Golgi.
Protein Description	Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. [PubMed: 7876235 The resulting epitope plays a role in cell-cell interaction including host-microbe interaction]
Protein Sequence	MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLASTSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
188	N-linked_Glycosylation	FLRGLQVNGSRPGTF HHHCCCCCCCCCCEE	29.75	UniProtKB CARBOHYD
205	Phosphorylation	VHVRRGDYVHVMPKV EEEECCCEEEECCCE	8.69	-
282	N-linked_Glycosylation	FALLTQCNHTIMTIG HHHHHCCCCEEEECC	26.06	UniProtKB CARBOHYD
308	N-linked_Glycosylation	GDTIYLANYTLPDSP CCEEEEEECCCCCCC	27.94	UniProtKB CARBOHYD
314	Phosphorylation	ANYTLPDSPFLKIFK EECCCCCCCCHHHCC	18.66	24719451
338	Phosphorylation	TGIAADLSPLLKH-- CCCCCCCHHHHCC--	17.66	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FUT2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FUT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FUT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FUT2_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FUT2_HUMAN

Related Literatures of Post-Translational Modification